Patents by Inventor Stephen John Bagnato
Stephen John Bagnato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230221223Abstract: A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.Type: ApplicationFiled: March 13, 2023Publication date: July 13, 2023Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Kenneth HENG-CHONG NG, Mark Brian Dockrill, Peter Toogood, Martin Limon, Daniel Dobrogorsky, Mark Wilcock, Greg Boyes, Brendyn Rodgers, Stephen John Bagnato, Ashan Chiranga Perera
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Patent number: 11635356Abstract: A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.Type: GrantFiled: June 24, 2020Date of Patent: April 25, 2023Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Kenneth Heng-Chong Ng, Mark Brian Dockrill, Peter Toogood, Martin Limon, Daniel Dobrogorsky, Mark Wilcock, Greg Boyes, Brendyn Rodgers, Stephen John Bagnato, Ashan Chiranga Perera
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Publication number: 20230077728Abstract: A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member.Type: ApplicationFiled: July 20, 2022Publication date: March 16, 2023Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Mark Brian DOCKRILL, Anthony FAVALORO, Kenneth HE-CHO NG, Martin LIMON, Peter TOOGOOD, Stephen John BAGNATO
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Patent number: 11420200Abstract: A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member.Type: GrantFiled: January 3, 2020Date of Patent: August 23, 2022Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Mark Brian Dockrill, Anthony Favaloro, Kenneth Heng-Chong Ng, Martin Limon, Peter Toogood, Stephen John Bagnato
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Publication number: 20210121884Abstract: The present invention relates broadly to production of a reagent on-board an instrument. The instrument is provided with a probe for dispensing said reagent, a concentrate chamber adapted to contain a concentrate and a diluent chamber adapted to contain a diluent. The probe includes an in-line mixing chamber adapted to receive the concentrate and the diluent to provide the reagent at the required concentration for dispensing by the probe.Type: ApplicationFiled: October 8, 2020Publication date: April 29, 2021Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventor: Stephen John BAGNATO
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Publication number: 20210080359Abstract: A thermal system for controllably altering a temperature within a reaction chamber in a sample processing assembly is described. The reaction chamber is bounded by a substrate and cover member in the sample processing assembly. The thermal system includes at least one thermal generator for generating temperature changes, one or more transfer layers for transferring temperature changes between the thermal generator and the sample on the substrate and a fluid isolator for isolating the thermal generator from fluid dispensed into the reaction chamber.Type: ApplicationFiled: November 10, 2020Publication date: March 18, 2021Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Peter TOOGOOD, Kenneth HENG-CHONG NG, Anthony FAVALORO, Stephen John BAGNATO, Gregory William BOYES
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Patent number: 10876936Abstract: A thermal system for controllably altering a temperature within a reaction chamber in a sample processing assembly is described. The reaction chamber is bounded by a substrate and cover member in the sample processing assembly. The thermal system includes at least one thermal generator for generating temperature changes, one or more transfer layers for transferring temperature changes between the thermal generator and the sample on the substrate and a fluid isolator for isolating the thermal generator from fluid dispensed into the reaction chamber.Type: GrantFiled: December 3, 2013Date of Patent: December 29, 2020Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Peter Toogood, Kenneth Heng-Chong Ng, Anthony Favaloro, Stephen John Bagnato, Gregory William Boyes
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Patent number: 10718695Abstract: A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.Type: GrantFiled: October 30, 2018Date of Patent: July 21, 2020Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Kenneth Heng-Chong Ng, Mark Brian Dockrill, Peter Toogood, Martin Limon, Daniel Dobrogorsky, Mark Wilcock, Greg Boyes, Brendyn Rodgers, Stephen John Bagnato, Ashan Chiranga Perera
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Publication number: 20200188904Abstract: A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member.Type: ApplicationFiled: January 3, 2020Publication date: June 18, 2020Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Mark Brian Dockrill, Anthony Favaloro, Kenneth Heng-Chong Ng, Martin Limon, Peter Toogood, Stephen John Bagnato
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Patent number: 10549271Abstract: A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member.Type: GrantFiled: November 15, 2012Date of Patent: February 4, 2020Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LIMITEDInventors: Mark Brian Dockrill, Anthony Favaloro, Kenneth Heng-Chong Ng, Martin Limon, Peter Toogood, Stephen John Bagnato
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Publication number: 20190078986Abstract: A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.Type: ApplicationFiled: October 30, 2018Publication date: March 14, 2019Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Kenneth Heng-Chong NG, Mark Brian DOCKRILL, Peter TOOGOOD, Martin LIMON, Daniel DOBROGORSKY, Mark WILCOCK, Greg BOYES, Brendyn RODGERS, Stephen John BAGNATO, Ashan Chiranga PERERA
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Patent number: 10145767Abstract: A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.Type: GrantFiled: November 1, 2013Date of Patent: December 4, 2018Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Kenneth Heng-chong Ng, Mark Brian Dockrill, Peter Toogood, Martin Limon, Daniel Dobrogorsky, Mark Wilcock, Greg Boyes, Brendyn Rodgers, Stephen John Bagnato, Ashan Chiranga Perera
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Patent number: 9395284Abstract: An automated method and system for treating one or more tissue samples disposed on slides, the system comprising: a controller, a plurality of slide treatment modules arranged to receive ones of the slides; at least one fluid dispensing robot configured by the controller to dispense a plurality of reagents to said ones of the slides received in the slide treatment modules via an output nozzle disposed on the at least one fluid dispensing robot to treat said one or more tissue samples respectively; and at least one pumping means for pumping said reagents to the output nozzle of the at least one fluid dispensing robot from a plurality of reagent containers comprising said reagents, wherein the at least one fluid dispensing robot is configured by the controller to dispense said reagents in a predetermined sequence for each of the slide treatment modules to treat the one or more tissue samples disposed on each of the slides independently.Type: GrantFiled: November 15, 2012Date of Patent: July 19, 2016Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Anthony Favaloro, Luke Restorick, Michael Houston Drummond, Stephen John Bagnato
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Publication number: 20150343445Abstract: The present invention relates broadly to production of a reagent on-board an instrument. The instrument is provided with one or more mixing wells 10 for dilution of a concentrate 12 with a diluent to provide the reagent at the required concentration.Type: ApplicationFiled: December 20, 2013Publication date: December 3, 2015Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventor: Stephen John BAGNATO
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Publication number: 20150308931Abstract: A thermal system for controllably altering a temperature within a reaction chamber in a sample processing assembly is described. The reaction chamber is bounded by a substrate and cover member in the sample processing assembly. The thermal system includes at least one thermal generator for generating temperature changes, one or more transfer layers for transferring temperature changes between the thermal generator and the sample on the substrate and a fluid isolator for isolating the thermal generator from fluid dispensed into the reaction chamber.Type: ApplicationFiled: December 3, 2013Publication date: October 29, 2015Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Peter TOOGOOD, Kenneth Heng-Chong NG, Anthony FAVALORO, Stephen John BAGNATO, Gregory William BOYES
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Publication number: 20150253225Abstract: A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.Type: ApplicationFiled: November 1, 2013Publication date: September 10, 2015Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Kenneth Heng-chong Ng, Mark Brian Dockrill, Peter Toogood, Martin Limon, Daniel Dobrogorsky, Mark Wilcock, Greg Boyes, Brendyn Rodgers, Stephen John Bagnato, Ashan Chiranga Perera
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Publication number: 20140329270Abstract: An automated method and system for treating one or more tissue samples disposed on slides, the system comprising: a controller, a plurality of slide treatment modules arranged to receive ones of the slides; at least one fluid dispensing robot configured by the controller to dispense a plurality of reagents to said ones of the slides received in the slide treatment modules via an output nozzle disposed on the at least one fluid dispensing robot to treat said one or more tissue samples respectively; and at least one pumping means for pumping said reagents to the output nozzle of the at least one fluid dispensing robot from a plurality of reagent containers comprising said reagents, wherein the at least one fluid dispensing robot is configured by the controller to dispense said reagents in a predetermined sequence for each of the slide treatment modules to treat the one or more tissue samples disposed on each of the slides independently.Type: ApplicationFiled: November 15, 2012Publication date: November 6, 2014Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Anthony Favaloro, Luke Restorick, Michael Houston Drummond, Stephen John Bagnato
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Patent number: D908915Type: GrantFiled: August 22, 2017Date of Patent: January 26, 2021Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Stephen John Bagnato, Orlando Skeete, Frank Austin, Eric Nicolas Baessler, Simon Peter Harris
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Patent number: D935639Type: GrantFiled: December 22, 2020Date of Patent: November 9, 2021Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Stephen John Bagnato, Orlando Skeete, Frank Austin, Eric Nicolas Baessler, Simon Peter Harris
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Patent number: D935640Type: GrantFiled: December 22, 2020Date of Patent: November 9, 2021Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Stephen John Bagnato, Orlando Skeete, Frank Austin, Eric Nicolas Baessler, Simon Peter Harris