Patents by Inventor Stephen John Ralph

Stephen John Ralph has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9770503
    Abstract: The present invention discloses immunomodulating compositions. More particularly, the present invention discloses compositions comprising an immune-modulating agent and a lectin-interactive agent, which are useful for stimulating and prolonging host immune cell responses. The compositions of the present invention are particularly useful in the treatment and/or prophylaxis of a range of conditions including pathogenic infections, autoimmune diseases, transplant rejection, graft versus host disease, allergies, inflammatory disease, as well as cancers and tumors.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: September 26, 2017
    Assignee: CANCURE LIMITED ACN 164 438 359
    Inventor: Stephen John Ralph
  • Publication number: 20150265701
    Abstract: The present invention discloses immunomodulating compositions. More particularly, the present invention discloses compositions comprising an immune-modulating agent and a lectin-interactive agent, which are useful for stimulating and prolonging host immune cell responses. The compositions of the present invention are particularly useful in the treatment and/or prophylaxis of a range of conditions including pathogenic infections, autoimmune diseases, transplant rejection, graft versus host disease, allergies, inflammatory disease, as well as cancers and tumours.
    Type: Application
    Filed: June 5, 2015
    Publication date: September 24, 2015
    Inventor: Stephen John Ralph
  • Patent number: 9050352
    Abstract: The present invention discloses immunomodulating compositions. More particularly, the present invention discloses compositions comprising an immune-modulating agent and a lectin-interactive agent, which are useful for stimulating and prolonging host immune cell responses. The compositions of the present invention are particularly useful in the treatment and/or prophylaxis of a range of conditions including pathogenic infections, autoimmune diseases, transplant rejection, graft versus host disease, allergies, inflammatory disease, as well as cancers and tumours.
    Type: Grant
    Filed: October 18, 2004
    Date of Patent: June 9, 2015
    Inventor: Stephen John Ralph
  • Patent number: 8598145
    Abstract: This invention relates to anti-cancer compounds and to methods for treating or preventing cancer. In one aspect the invention concerns mitochondrially delivered pro-oxidant anti-cancer compounds that generate reactive oxygen species and induce apoptosis of cancerous cells. The delivery moiety can be a lipophilic cation and the pro-oxidant vitamin E analogue, such as ?-tocopheryl succinate, ?-tocopheryl maleate, ?-tocopheryl maleyl amide, or 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)-chroman-6-yloxyacetic acid (?-tocopheryloxyacetic acid).
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: December 3, 2013
    Inventors: Stephen John Ralph, Jiri Neuzil
  • Patent number: 8410056
    Abstract: This invention relates to anti-cancer compounds and to methods for treating or preventing cancer. In particular, the invention concerns pro-oxidant anti-cancer compounds, such as pro-oxidant forms of vitamin E that selectively interact with complex II of the mitochondrial respiratory chain of cancerous cells, generate reactive oxygen species and induce apoptosis of those cells.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: April 2, 2013
    Inventors: Stephen John Ralph, Jiri Neuzil
  • Patent number: 7964400
    Abstract: A composition of matter is disclosed, comprising an immunostimulatory molecule and animal cells cultured in the presence of at least one interferon (IFN) for a time and under conditions sufficient to enhance the antigen presenting function of said cells. Also disclosed are immunopotentiating compositions and their use for treatment and/or prophylaxis of a disease or condition.
    Type: Grant
    Filed: October 27, 2008
    Date of Patent: June 21, 2011
    Inventor: Stephen John Ralph
  • Publication number: 20110105437
    Abstract: This invention relates to anti-cancer compounds and to methods for treating or preventing cancer. In one aspect the invention concerns mitochondrially delivered pro-oxidant anti-cancer compounds that generate reactive oxygen species and induce apoptosis of cancerous cells. The delivery moiety can be a lipophilic cation and the pro-oxidant vitamin E analogue, such as ?-tocopheryl succinate, ?-tocopheryl maleate, ?-tocopheryl maleyl amide, or 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)-chroman-6-yloxyacetic acid (?-tocopheryloxyacetic acid).
    Type: Application
    Filed: March 16, 2009
    Publication date: May 5, 2011
    Inventors: Stephen John Ralph, Jiri Neuzil
  • Publication number: 20110059898
    Abstract: This invention relates to anti-cancer compounds and to methods for treating or preventing cancer. In particular, the invention concerns pro-oxidant anti-cancer compounds, such as pro-oxidant forms of vitamin E, that selectively interact with complex II of the mitochondrial respiratory chain of cancerous cells, generate reactive oxygen species and induce apoptosis of those cells.
    Type: Application
    Filed: September 17, 2007
    Publication date: March 10, 2011
    Inventors: Stephen John Ralph, Jiri Neuzil
  • Publication number: 20090081792
    Abstract: A composition of matter is disclosed, comprising an immunostimulatory molecule and animal cells cultured in the presence of at least one interferon (IFN) for a time and under conditions sufficient to enhance the antigen presenting function of said cells. Also disclosed are immunopotentiating compositions and their use for treatment and/or prophylaxis of a disease or condition.
    Type: Application
    Filed: October 27, 2008
    Publication date: March 26, 2009
    Inventor: STEPHEN JOHN RALPH
  • Patent number: 7455846
    Abstract: The present invention relates various compositions having an immunostimulatory molecule and animal cells cultured in the presence of at least one interferon (IFN) of type I or type II for time and conditions sufficient to enhance the antigen presenting function of the cells. Other aspects of the present invention include methods of treatment and/or prophylaxis of a disease or condition using these immunopotentiating compositions.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: November 25, 2008
    Inventor: Stephen John Ralph
  • Publication number: 20040235156
    Abstract: The present invention relates various compositions having an immunostimulatory molecule and animal cells cultured in the presence of at least one interferon (IFN) of type I or type II for time and conditions sufficient to enhance the antigen presenting function of the cells. Other aspects of the present invention include methods of treatment and/or prophylaxis of a disease or condition using these immunopotentiating compositions.
    Type: Application
    Filed: June 30, 2003
    Publication date: November 25, 2004
    Inventor: Stephen John Ralph
  • Patent number: RE47300
    Abstract: This invention relates to anti-cancer compounds and to methods for treating or preventing cancer. In one aspect the invention concerns mitochondrially delivered pro-oxidant anti-cancer compounds that generate reactive oxygen species and induce apoptosis of cancerous cells. The delivery moiety can be a lipophilic cation and the pro-oxidant moiety can be a pro-oxidant vitamin E analogue, such as ?-tocopheryl succinate, ?-tocopheryl maleate, ?-tocopheryl maleyl amide, or 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)-chroman-6-yloxyacetic acid (?-tocopheryloxyacetic acid).
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: March 19, 2019
    Assignee: CANCURE LIMITED
    Inventors: Stephen John Ralph, Jiri Neuzil