Abstract: Multimodal optical imaging is disclosed. Possible devices include a filter assembly that is capable of rotary action during real time image acquisition. Systems are disclosed that include such filter assemblies, which are detachable or integrated in the systems. Various techniques for capturing image targets using multiple light sources such as white light and fluorescent light are also disclosed.

Abstract: Multimodal optical imaging is disclosed. Possible devices include a filter assembly that is capable of rotary action during real time image acquisition. Systems are disclosed that include such filter assemblies, which are detachable or integrated in the systems. Various techniques for capturing image targets using multiple light sources such as white light and fluorescent light are also disclosed.

Abstract: The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site.

Abstract: A technique is provided for imaging based on localization of fluorescence in a medium. The technique includes illuminating the medium with an excitation light to excite fluorescence, scanning the medium at a plurality of locations via an ultrasonic beam, modulating a portion of the emitted light from the fluorescence via the ultrasonic beam at each of the plurality of locations, differentially detecting the modulated light at a boundary of the medium, and reconstructing an image from the detected signal.

Abstract: The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site.

Abstract: Provided herein are devices, systems, and methods for multimodal optical imaging. The devices include a filter assembly that is capable of rotary action during real time image acquisition. The systems include such filter assemblies, which are detachable or integrated in the systems. The methods include techniques for capturing image targets using multiple light sources such as white light and fluorescent light.

Abstract: Provided herein are devices, systems, and methods for multimodal optical imaging. The devices include a filter assembly that is capable of rotary action during real time image acquisition. The systems include such filter assemblies, which are detachable or integrated in the systems. The methods include techniques for capturing image targets using multiple light sources such as white light and fluorescent light.

Abstract: A method and system for fluorescence imaging of a target in a subject comprising a scattering medium is provided. The method comprises illuminating one or more points on a surface of the scattering medium using an illumination source, wherein the plurality of points define an illumination region, collecting emitted light from an illumination region and an area away from the illumination region, and generating an image of the scattering medium using the emitted light.

Abstract: The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site.

Abstract: The invention relates to imaging methods and systems. The systems may comprise a white light source configured to generate light in a first wavelength range, an excitation source configured to generate light at one or more wavelengths for exciting a fluorescent substance, a first detector configured to acquire reflectance image data that represents white light reflected from a subject, and a second detector configured to acquire fluorescence image data that represents fluorescence emissions from the subject. At least one of the one or more wavelengths generated by the excitation light source is within the first wavelength range of the white light source. The fluorescent substance may be, for example, a fluorescent dye that is injected into a patient before or during a surgery. The system may also include an image processing engine and a display.

Abstract: A method of visualizing nerves by observing the hemodynamic response of the blood flow comprising: acquiring a pre-stimulus image of a target tissue; providing a stimulus to the target tissue; introducing a time delay between the stimulus and a post-stimulus image; capturing the post-stimulus image of the target tissue; and producing a processed image based on a comparison between the pre-stimulus image and the post-stimulus image. Also described is a system for evaluating the hemodynamic response of blood flow comprising producing a processed image based on a comparison between the pre-stimulus image and the post-stimulus image.

Abstract: A system provides a multi-axis translation and orientation capability for optical imaging. The system includes an optical imaging apparatus providing a signal representing a digitized image, and a mechanical frame. The frame includes a first set of articulations capable of independently translating the optical imaging apparatus in multiple linear directions. The system also includes a second set of articulations formed as joints providing at least three independent degrees of rotation of the optical imaging apparatus. The system also provides an opening configured to permit the frame to be postured about a patient such that an isocenter corresponds to a region of interest of the patient, and includes an illumination source attached to the frame and configured to direct illumination towards the isocenter. The system also comprises a camera system co-located with the illumination source and having a focal plane at the isocenter.

Abstract: A method and system for fluorescence imaging of a target in a subject comprising a scattering medium is provided. The method comprises illuminating one or more points on a surface of the scattering medium using an illumination source, wherein the plurality of points define an illumination region, collecting emitted light from an illumination region and an area away from the illumination region, and generating an image of the scattering medium using the emitted light.

Abstract: A modular, scalable and configurable incoherent light source is provided. The light source includes an array of lighting modules supported on a frame that focuses emitted radiation from the modules at a region of interest. The geometry and physical configuration of the support structures, including the frame, may accommodate various energy intensities at various distances. The modules may be made up of multiple LEDs or other individual light sources, may be of different or the same wavelength, and may be individually controllable for the ultimate lighting application. The light source may be used in medical imaging applications.

Abstract: A system provides a multi-axis translation and orientation capability for optical imaging. The system includes an optical imaging apparatus providing a signal representing a digitized image, and a mechanical frame. The frame includes a first set of articulations capable of independently translating the optical imaging apparatus in multiple linear directions. The system also includes a second set of articulations formed as joints providing at least three independent degrees of rotation of the optical imaging apparatus. The system also provides an opening configured to permit the frame to be postured about a patient such that an isocenter corresponds to a region of interest of the patient, and includes an illumination source attached to the frame and configured to direct illumination towards the isocenter. The system also comprises a camera system co-located with the illumination source and having a focal plane at the isocenter.

Abstract: Optical imaging systems and methods are disclosed. The optical imaging system includes an electronic imaging device configured to capture an image of a site and a projector. An optical imaging system includes a projector configured to project a visible representation of the captured image onto the site during surgery. Another optical imaging system includes an optical element capable of aligning an optical axis of the electronic imaging device and the projector on a same optical axis. Also disclosed are methods for displaying an image on to a site. A method includes capturing a fluorescent image of a surgical site; and projecting a visible representation of the captured image onto the surgical site during surgery. Another method includes projecting a visible representation of a captured image of a site onto the site along a same optical axis along which the image is captured.