Patents by Inventor Stephen L. Gluck

Stephen L. Gluck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regeneration of kidney tissue and use of autocrine growth factors
    Patent number: 5821218
    Abstract: Autocrine growth factors and isoforms of those factors have been identified, isolated, purified and manipulated. Nucleic acid segments coding for the factors, and antibodies directed to the factors are also aspects of the present invention. The effect of these growth factors on cells is to enhance their growth by increasing mitogenesis. In particular, the growth factors stimulate kidney epithelial cell growth. The growth factors differ from others previously reported in their molecular weights and other properties, for example, resistance to denaturation by dithiothreitol. Methods of preparation and use of the factors are also described. The growth factors are released from kidney epithelial cells by short exposures to a low-sodium environment. The factors have potential for treatment of kidney disease.
    Type: Grant
    Filed: December 15, 1995
    Date of Patent: October 13, 1998
    Assignee: ARCH Development Corporation
    Inventors: F. Gary Toback, Stephen L. Gluck, Margaret M. Walsh-Reitz
  • Methods and compositions for the preparation and use of autocrine growth factors
    Patent number: 5476922
    Abstract: Autocrine growth factors and isoforms of those factors have been identified, isolated, purified and manipulated. Nucleic acid segments coding for the factors, and antibodies directed to the factors are also aspects of the present invention. The effect of these growth factors on cells is to enhance their growth by increasing mitogenesis. In particular, the growth factors stimulate kidney epithelial cell growth. The growth factors differ from others previously reported in their molecular weights and other properties, for example, resistance to denaturation by dithiothreitol. Methods of preparation and use of the factors are also described. The growth factors are released from kidney epithelial cells by short exposures to a low-sodium environment. The factors have potential for treatment of kidney disease.
    Type: Grant
    Filed: September 22, 1993
    Date of Patent: December 19, 1995
    Assignee: ARCH Development Corporation
    Inventors: F. Gary Toback, Margaret Walsh-Reitz, Stephen L. Gluck
  • Production of autocrine growth factors
    Patent number: 5135856
    Abstract: A method of producing autocrine growth factors from kidney epithelial cells by lowering the extracellular sodium concentration. The invention also concerns new growth factors, a method of producing the new growth factors, and the medium used to produce these new growth factors.
    Type: Grant
    Filed: June 24, 1987
    Date of Patent: August 4, 1992
    Assignee: ARCH Development Corp.
    Inventors: F. Gary Toback, Margaret M. Walsh-Reitz, Stephen L. Gluck