Abstract: The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N?-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma. The crystalline solid forms can be used to make the L-malate salt of cabozantinib.

Abstract: The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N?-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma. The crystalline solid forms can be used to make the L-malate salt of cabozantinib.

Abstract: The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N?-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma. The crystalline solid forms can be used to make the L-malate salt of cabozantinib.

Abstract: Disclosed are various embodiments for real-time detection of duplicate data records. A duplicate detection application generates a set of clusters from a set of data records by grouping each data record in the set of data records according to similarity to respective centroid data records of the set of clusters. The duplicate detection application determines whether a particular data record has a potential duplicate in the set of data records by first comparing the particular data record to the respective centroid data records to identify a most similar cluster in the set of clusters. The duplicate detection application then compares the particular data record to each data record in the most similar cluster.

Abstract: A method and system on an electronic device which uses speech recognition to initiate a communication from a mobile device having access to contact information for a number of contacts. In one example, the method comprises receiving through an audio input interface a voice input for initiating a communication, extracting from the voice input a type of communication and at least part of a contact name, and outputting, to an output interface, a selectable list of all contacts from the contact information which have the part of the contact name and which have a contact address associated with the type of communication. The mobile device may also be configured to access remote contact information from a remote server.

Abstract: The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N?-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma. The crystalline solid forms can be used to make the L-malate salt of cabozantinib.

Abstract: The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N?-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma. The crystalline solid forms can be used to make the L-malate salt of cabozantinib.

Abstract: The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N?-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma. The crystalline solid forms can be used to make the L-malate salt of cabozantinib.

Abstract: A system for generating operational metrics data for a medical care facility includes a first camera and an operational metrics device. The first camera generates digital images of a first detection area. The operational metrics device includes an optical code detector, a medical object detector, and an operational metrics generator. The optical code detector generates optical code detection data indicative of the presence or absence of optical codes within each of the digital images. Each of the optical codes is disposed on a respective medical object. The medical object detector generates medical object detection data indicative the presence or absence of each medical object within the first detection area. For each medical object, the operational metrics generator generates operational metrics data based at least partially on a determined amount of time that each medical object was present within the first detection area.

Abstract: The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N?-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma. The crystalline solid forms can be used to make the L-malate salt of cabozantinib.

Abstract: This document describes techniques using, and devices embodying, integral program content distribution. These techniques and devices enable a request for program content to be received from an end-user device. In response to the request, an integral version of the requested program content is determined using an indication of a program content transition that corresponds to an apparent broadcast time of the requested program content. The program content can be transmitted to the end-user device as part of a cloud-based digital video recorder (DVR) system.

Abstract: A temperature controlled showerhead for chemical vapor deposition (CVD) chambers enhances heat dissipation to enable accurate temperature control with an electric heater. Heat dissipates by conduction through a showerhead stem and fluid passageway and radiation from a back plate. A temperature control system includes one or more temperature controlled showerheads in a CVD chamber with fluid passageways serially connected to a heat exchanger.

Abstract: An air fragrance diffuser system for use in an automobile includes a battery and an electronic control system communicably coupled to a wireless transceiver associated with a user. The diffuser system includes an air pump for generating a pressurized air. The diffuser system further includes an atomizer device pneumatically coupled to the air pump for receiving the pressurized air to convert fragrance oil stored in the atomizer device into fragrance mist using the pressurized air based on a jet nebulization process. In an embodiment, the diffuser system further includes a transmission system coupled to the atomizer device for receiving the fragrance mist, and for providing the fragrance mist into a passenger compartment of the automobile. In another embodiment, the transmission system provides the mixture into the passenger compartment using existing vents of a Heating, Ventilation, and Air Conditioning (HVAC) system of the automobile.

Abstract: A system includes at least two capture devices, each switchable from a respective idle mode to a respective recording mode upon receipt of a trigger signal from a trigger via a network. A controller saves data packets generated by the capture devices during the respective idle modes to a short-term memory, and saves data packets generated during the respective recording modes to a long-term memory such that the data packets form respective saved data streams. The synchronizer sends a sync signal to the capture devices via the network. The compensator determines respective delay periods between sending of the sync signal by the synchronizer and receipt of the sync signal by each of the capture devices, and transfers from the short-term memory to the long-term memory any data packets generated during the respective delay period.

Abstract: The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N?-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma. The crystalline solid forms can be used to make the L-malate salt of cabozantinib.

Abstract: Methods and electronic devices for facilitating communication are described. In one example, the present application describes processor-implemented method. The method includes: receiving an audio signal; determining that the audio signal includes a voice command to communicate with a contact using a first communication type; and determining that communication with the contact using the first communication type is unavailable; and after determining that communication with the contact using the first communication type is unavailable, facilitating communication with the contact using a second communication type.

Abstract: A method and system on an electronic device which uses speech recognition to initiate a communication from a mobile device having access to contact information for a number of contacts. In one example, the method comprises receiving through an audio input interface a voice input for initiating a communication, extracting from the voice input a type of communication and at least part of a contact name, and outputting, to an output interface, a selectable list of all contacts from the contact information which have the part of the contact name and which have a contact address associated with the type of communication. The mobile device may also be configured to access remote contact information from a remote server.

Abstract: This document describes techniques using, and devices embodying, integral program content distribution. These techniques and devices enable a request for program content to be received from an end-user device. In response to the request, an integral version of the requested program content is determined using an indication of a program content transition that corresponds to an apparent broadcast time of the requested program content. The program content can be transmitted to the end-user device as part of a cloud-based digital video recorder (DVR) system.

Abstract: A temperature controlled showerhead for chemical vapor deposition (CVD) chambers enhances heat dissipation to enable accurate temperature control with an electric heater. Heat dissipates by conduction through a showerhead stem and fluid passageway and radiation from a back plate. A temperature control system includes one or more temperature controlled showerheads in a CVD chamber with fluid passageways serially connected to a heat exchanger.

Abstract: This document describes techniques using, and devices embodying, integral program content distribution. These techniques and devices enable a request for program content to be received from an end-user device. In response to the request, an integral version of the requested program content is determined using an indication of a program content transition that corresponds to an apparent broadcast time of the requested program content. The program content can be transmitted to the end-user device as part of a cloud-based digital video recorder (DVR) system.