Abstract: An improved mycelium in the form of an edible aerial mycelium that is suitable for use as a food product, including a food ingredient for making mycelium-based food, such as bacon. A method of making an edible aerial mycelium suitable for use as a food product, including a food ingredient. An edible product containing an edible aerial mycelium, and a method of making an edible product comprising an edible aerial mycelium, such as a mycelium-based bacon. A mycelium-based food product having a texture that is analogous to a whole-muscle meat product, wherein that whole-muscle meat product is bacon.

Abstract: This application relates generally to aerial mycelium and methods of making aerial mycelium suitable for use as a food or textile product or ingredient. Such a food product or ingredient can include edible aerial mycelium having a texture that is analogous to a whole-muscle meat product, such as for example mycelium-based bacon. Such a textile product or ingredient can be used in the manufacture of mycelium-based textile products, leather-like materials, petroleum-based product alternatives, or foams.

Abstract: An improved mycelium in the form of an edible aerial mycelium that is suitable for use as a food product, including a food ingredient for making mycelium-based food, such as bacon. A method of making an edible aerial mycelium suitable for use as a food product, including a food ingredient. An edible product containing an edible aerial mycelium, and a method of making an edible product comprising an edible aerial mycelium, such as a mycelium-based bacon. A mycelium-based food product having a texture that is analogous to a whole-muscle meat product, wherein that whole-muscle meat product is bacon.

Abstract: A method for enhancing contrast in fluorescence imaging is provided. The method comprises providing a patterned illumination source for illuminating one or more regions corresponding to a scan step, scanning at least a portion of a surface of a subject using a plurality of scan steps, acquiring image frames corresponding to two or more scan steps, deducting a background fluorescence from the image frames corresponding to the two or more scan steps to form one or more processed image frames, and reconstructing an image using one or more of the processed image frames.

Abstract: A method for enhancing contrast in fluorescence imaging is provided. The method comprises providing a patterned illumination source for illuminating one or more regions corresponding to a scan step, scanning at least a portion of a surface of a subject using a plurality of scan steps, acquiring image frames corresponding to two or more scan steps, deducting a background fluorescence from the image frames corresponding to the two or more scan steps to form one or more processed image frames, and reconstructing an image using one or more of the processed image frames.

Abstract: Provided herein are image-enhancing agents that are useful for managing disease by imaging disease tissue using magnetic resonance imaging techniques, optical imaging techniques, and a combination of magnetic resonance imaging techniques and optical imaging techniques. Also provided are methods of imaging disease tissue and managing disease using the image-enhancing agents.

Abstract: A combined modality imaging system includes a first imaging device of a first modality and a second imaging device of a second modality that is different from the first modality is provided. The first and the second imaging devices are both adapted to interact with a contrast agent. The contrast agent includes a deformable particle that has a geometry that varies in response to an emission from the first imaging device. The deformable particle also includes a fluorescent component and a quenching component separated from the fluorescent component at a characteristic distance.

Abstract: Methods and compositions for detecting and localizing light from a subject are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the subject. Also disclosed are methods for locating a target in a subject, such as by detecting light emission from a target site.

Abstract: A method and system for adaptive acquisition of magnetic resonance imaging (MRI) data by initially performing an analysis of a set of samples using a wide range of spin-lattice relaxation time (T1) times, and spin-spin relaxation time (T2) times of the sample under magnetic resonance imaging, and ranking the level of impact each of those T1s and T2s has on inversion times (TIs) and echo times (TEs) respectively. The method and system create a look-up table based on the data generated, and then perform another measurement using a smaller number of T1s and T2s using a small number of TIs and TEs, and compare the results to the data in the look-up table in order to select the closest point in the look-up table.

Abstract: A technique is provided for imaging based on localization of fluorescence in a medium. The technique includes illuminating the medium with an excitation light to excite fluorescence, scanning the medium at a plurality of locations via an ultrasonic beam, modulating a portion of the emitted light from the fluorescence via the ultrasonic beam at each of the plurality of locations, differentially detecting the modulated light at a boundary of the medium, and reconstructing an image from the detected signal.

Abstract: In accordance with embodiments of the present technique, a combined modality imaging system includes a first imaging device of a first modality and a second imaging device of a second modality that is different from the first modality. The first and the second imaging devices are both adapted to interact with a contrast agent adapted to be received in a subject. The contrast agent includes an deformable particle that has a geometry that varies in response to an emission from the first imaging device. The deformable particle also includes a fluorescent component adapted to emit electromagnetic radiation that is detectable by the second imaging device and a quenching component separated from the fluorescent component at a distance based on the geometry and that which is adapted to absorb a portion of the electromagnetic radiation from the fluorescent component.

Abstract: An illumination device comprising: an incoherent light source; a non-imaging light collection system disposed to collect light emitted by the light source; an electro-optic modulator that receives light collected by the light collection system and modulates its intensity; and a light delivery system that receives intensity-modulated light output by the electro-optic modulator and illuminates an area with diverging intensity-modulated light. High-powered incoherent, multi-spectral illumination sources, such as lamps or LED arrays, are used. Non-imaging light collection elements, such as fiber optic bundles, total internal reflection lens arrays or compound parabolic light concentrators, are used to reduce the divergence of the light source for efficient transmission of light through an electro-optic modulator.

Abstract: A method and system for localization of fluorescence in a scattering medium such as a biological tissue are provided. In comparison to other optical imaging techniques, this disclosure provides for improved spatial resolution, decreased computational time for reconstructions, and allows anatomical and functional imaging simultaneously. The method including the steps of illuminating the scattering medium with an excitation light to excite the fluorescence; modulating a portion of the emitted light from the fluorescence within the scattering medium using an ultrasonically induced variation of material properties of the scattering medium such as the refractive index; detecting the modulated optical signal at a surface of the scattering medium; and reconstructing a spatial distribution of the fluorescence in the scattering medium from the detected signal.