Patents by Inventor Stephen P. Beebe

Stephen P. Beebe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10660693
    Abstract: Systems and methods for treatment of a biological tissues including target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: May 26, 2020
    Assignee: Old Dominion University Research Foundation
    Inventors: Karl H. Schoenbach, Richard Heller, James Camp, Stephen P. Beebe, Shu Xiao, Amy Donate
  • Publication number: 20190038337
    Abstract: Systems and methods for treatment of a biological tissues including target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.
    Type: Application
    Filed: August 7, 2018
    Publication date: February 7, 2019
    Inventors: Karl H. SCHOENBACH, Richard HELLER, James CAMP, Stephen P. BEEBE, Shu XIAO, Amy DONATE
  • Patent number: 10070914
    Abstract: Systems and methods for treatment of a biological tissues comprising target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: September 11, 2018
    Assignee: Old Dominion University Research Foundation
    Inventors: Karl H. Schoenbach, Richard Heller, James Camp, Stephen P. Beebe, Shu Xiao, Amy Donate
  • Publication number: 20140364797
    Abstract: Systems and methods for treatment of a biological tissues comprising target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.
    Type: Application
    Filed: December 20, 2012
    Publication date: December 11, 2014
    Inventors: Karl H. Schoenbach, Richard Heller, James Camp, Stephen P. Beebe, Shu Xiao, Amy Donate
  • Patent number: 8798705
    Abstract: An instrument 10 for delivering a high voltage pulse to tissue is disclosed. The instrument 10 can include an outer support member 12 with a liquid reservoir 14 that has a liquid-contacting interior surface 16, an opening 18 at a distal end 20 of the outer support member 12, and a ground electrode 22 extending in a longitudinal direction and having a lower surface 23 proximate the opening 18. The instrument 10 can also include a working electrode 26 extending longitudinally from the liquid-contacting interior surface 16 with a needle-shaped distal portion 28 proximate the distal end 20; and an inlet port 31 and an outlet port 34 in liquid communication with the liquid reservoir 14. The working electrode 26 can be electrically isolated from the ground electrode 22 by an insulating portion 30 of the outer support member 12, and a direct path can exist through the liquid reservoir 14 between the ground electrode 22 and the working electrode 26.
    Type: Grant
    Filed: April 14, 2010
    Date of Patent: August 5, 2014
    Assignee: Old Dominion University Research Foundation
    Inventors: Juergen F. Kolb, Karl H. Schoenbach, Stephen P. Beebe
  • Publication number: 20120109263
    Abstract: An instrument 10 for delivering a high voltage pulse to tissue is disclosed. The instrument 10 can include an outer support member 12 with a liquid reservoir 14 that has a liquid-contacting interior surface 16, an opening 18 at a distal end 20 of the outer support member 12, and a ground electrode 22 extending in a longitudinal direction and having a lower surface 23 proximate the opening 18. The instrument 10 can also include a working electrode 26 extending longitudinally from the liquid-contacting interior surface 16 with a needle-shaped distal portion 28 proximate the distal end 20; and an inlet port 31 and an outlet port 34 in liquid communication with the liquid reservoir 14. The working electrode 26 can be electrically isolated from the ground electrode 22 by an insulating portion 30 of the outer support member 12, and a direct path can exist through the liquid reservoir 14 between the ground electrode 22 and the working electrode 26.
    Type: Application
    Filed: April 14, 2010
    Publication date: May 3, 2012
    Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
    Inventors: Juergen F. Kolb, Karl H. Schoenbach, Stephen P. Beebe