Patents by Inventor Stephen P. Fletcher

Stephen P. Fletcher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Asymmetric addition reactions
    Patent number: 10464861
    Abstract: Processes of forming Csp2—Csp3 bonds at the allylic carbon of a cyclic allylic compound starting material are disclosed, in which a racemic mixture of a cyclic allylic compound having a leaving group attached to the allylic carbon is reacted with a compound having a nucleophilic carbon atom in the presence of a Rh(I), Pd(II) or Cu(I) pre-catalyst and a chiral ligand. The reaction products containing the newly-formed Csp2—Csp3 bond are generated in high stereoisomeric excess, and may therefore serve as important organic building blocks in the preparation of new agrochemicals and pharmaceuticals.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: November 5, 2019
    Assignee: Oxford University Innovation Limited
    Inventors: Stephen P. Fletcher, Mireia Sidera Portela
  • ASYMMETRIC ADDITION REACTIONS
    Publication number: 20180334414
    Abstract: Processes of forming Csp2—Csp3 bonds at the allylic carbon of a cyclic allylic compound starting material are disclosed, in which a racemic mixture of a cyclic allylic compound having a leaving group attached to the allylic carbon is reacted with a compound having a nucleophilic carbon atom in the presence of a Rh(I), Pd(II) or Cu(I) pre-catalyst and a chiral ligand. The reaction products containing the newly-formed Csp2—Csp3 bond are generated in high stereoisomeric excess, and may therefore serve as important organic building blocks in the preparation of new agrochemicals and pharmaceuticals.
    Type: Application
    Filed: June 1, 2016
    Publication date: November 22, 2018
    Inventors: Stephen P. Fletcher, Mireia Sidera Portela
  • Asymmetric synthesis of organic compounds
    Patent number: 9090545
    Abstract: The present invention provides processes for the production of chiral compounds in a stereoisomeric excess. The present processes involve reacting a hydrometallated alkene compound with a compound comprising a conjugated-bond system under conditions such that the compounds undergo an asymmetric 1,4- or 1,6-conjugate addition reaction, generating a chiral compound in a stereoisomeric excess. The reaction is performed in the presence of a metal catalyst, which catalyst preferably comprises a non-racemic chiral ligand.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: July 28, 2015
    Assignee: ISIS INNOVATION LIMITED
    Inventors: Stephen P. Fletcher, Rebecca M. Maksymowicz, Philippe M. C. Roth
  • ASYMMETRIC SYNTHESIS OF ORGANIC COMPOUNDS
    Publication number: 20140303385
    Abstract: The present invention provides processes for the production of chiral compounds in a stereoisomeric excess. The present processes involve reacting a hydrometallated alkene compound with a compound comprising a conjugated-bond system under conditions such that the compounds undergo an asymmetric 1,4- or 1,6-conjugate addition reaction, generating a chiral compound in a stereoisomeric excess. The reaction is performed in the presence of a metal catalyst, which catalyst preferably comprises a non-racemic chiral ligand.
    Type: Application
    Filed: October 12, 2012
    Publication date: October 9, 2014
    Applicant: Isis Innovation Limited
    Inventors: Stephen P. Fletcher, Rebecca M. Maksymowicz, Philippe M.C. Roth