Patents by Inventor Stephen Patrick Blythe
Stephen Patrick Blythe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9261478Abstract: Described are methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that a glucose concentration can be determined that is simpler, less error prone and provides the unexpected advantage of being insensitive to hematocrits in the blood sample.Type: GrantFiled: February 12, 2013Date of Patent: February 16, 2016Assignee: Cilag GmbH InternationalInventor: Stephen Patrick Blythe
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Patent number: 9046480Abstract: The method includes: providing a test strip comprising a reference electrode and a working electrode coated with a reagent layer; applying a fluid sample to the test strip for a reaction period; applying a test voltage between the reference electrode and the working electrode; measuring a test current as a function of time; measuring a steady state current value when the test current has reached an equilibrium; calculating a ratio of the test current to the steady state current value; plotting the ratio of the test current to the steady state current value as a function of the inverse square root of time; calculating an effective diffusion coefficient from the slope of the linearly regressed plot of the ratio of the test current to the steady state current value as a function of the inverse square root of time; and calculating a hematocrit-corrected concentration of analyte.Type: GrantFiled: March 4, 2013Date of Patent: June 2, 2015Assignee: LifeScan Scotland LimitedInventors: Stephen Patrick Blythe, Marco F. Cardosi, Andrew Gill, Leanne Mills, Christopher Philip Leach
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Patent number: 8815076Abstract: A method and system is provided to allow for determination of substantially Hematocrit independent analyte concentration. In one example, an analyte measurement system is provided that includes a test strip and a test meter. The test strip includes a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer. The test meter includes an electronic circuit and a signal processor. The electronic circuit applies a plurality of voltages to the reference electrode and the working electrode over respective durations. The signal processor is configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes.Type: GrantFiled: October 10, 2012Date of Patent: August 26, 2014Assignee: Lifescan Scotland LimitedInventors: Marco F. Cardosi, Stephen Patrick Blythe, Matthew Finch, Arlene Thompson, Nina Antonia Naylor, Eric Jason Bailey, Michael Patick Dolan, Gretchen Anderson, Lorraine Comstock, Mary McEvoy, Thomas Sutton, Richard Michael Day, Leanne Mills, Emma Vanessa Jayne Day, Christopher Philip Leach
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Publication number: 20140224674Abstract: Described are methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that a glucose concentration can be determined that is simpler, less error prone and provides the unexpected advantage of being insensitive to hematocrits in the blood sample.Type: ApplicationFiled: February 12, 2013Publication date: August 14, 2014Applicant: Cilag GmbH InternationalInventor: Stephen Patrick BLYTHE
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Publication number: 20130240375Abstract: The method includes: providing a test strip comprising a reference electrode and a working electrode coated with a reagent layer; applying a fluid sample to the test strip for a reaction period; applying a test voltage between the reference electrode and the working electrode; measuring a test current as a function of time; measuring a steady state current value when the test current has reached an equilibrium; calculating a ratio of the test current to the steady state current value; plotting the ratio of the test current to the steady state current value as a function of the inverse square root of time; calculating an effective diffusion coefficient from the slope of the linearly regressed plot of the ratio of the test current to the steady state current value as a function of the inverse square root of time; and calculating a hematocrit-corrected concentration of analyte.Type: ApplicationFiled: March 4, 2013Publication date: September 19, 2013Applicant: LifeScan Scotland LimitedInventors: Stephen Patrick BLYTHE, Marco F. CARDOSI, Andrew GILL, Leanne MILLS, Christopher Philip LEACH
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Patent number: 8460537Abstract: A method for determining an analyte concentration in blood is described that reduces the effects of hematocrit using a test strip attached to a test meter. The test strip includes a working electrode and a reference electrode. The test meter applies a test voltage between the working electrode and the reference electrode. After a user applies a blood sample containing an analyte onto the test strip, the test meter measures a plurality of test currents for a test time interval.Type: GrantFiled: September 3, 2009Date of Patent: June 11, 2013Assignee: LifeScan Scotland LimitedInventors: Stephen Patrick Blythe, Marco F Cardosi, Leanne Mills, Manuel Alvarez-Icaza, Emma Vanessa Jayne Day, Richard Michael Day, Christopher Philip Leach
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Patent number: 8388821Abstract: Description is provided herein for an embodiment of a method determining a hematocrit-corrected glucose concentration. The exemplary method includes providing a test strip having a reference electrode and a working electrode, wherein the working electrode includes a plurality of microelectrodes and is coated with at least an enzyme and a mediator.Type: GrantFiled: October 5, 2007Date of Patent: March 5, 2013Assignee: LifeScan Scotland LimitedInventors: Stephen Patrick Blythe, Marco F. Cardosi, Andrew Gill, Leanne Mills, Christopher Philip Leach
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Patent number: 8293096Abstract: A method and system is provided to allow for determination of substantially Hematocrit independent analyte concentration. In one example, an analyte measurement system is provided that includes a test strip and a test meter. The test strip includes a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer. The test meter includes an electronic circuit and a signal processor. The electronic circuit applies a plurality of voltages to the reference electrode and the working electrode over respective durations. The signal processor is configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes.Type: GrantFiled: January 22, 2010Date of Patent: October 23, 2012Assignee: LifeScan Scotland LimitedInventors: Marco F. Cardosi, Stephen Patrick Blythe, Matthew Finch, Arlene Thompson, Nina Antonia Naylor, Eric Jason Bailey, Michael Patrick Dolan, Gretchen Anderson, Lorraine Comstock, Mary McEvoy, Thomas Sutton, Richard Michael Day, Leanne Mills, Emma Vanessa Jayne Day, Christopher Philip Leach
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Publication number: 20120048746Abstract: An analyte test strip for use with a test meter includes a first insulating layer, a first electrically conductive layer disposed on the first insulating layer, a second insulating layer disposed above the first insulating layer, and a patterned spacer layer, positioned between the first insulating layer and the first electrically conductive layer, that defines a sample-receiving chamber. Moreover, the electrically conductive layer includes an electrode portion that is divided into a first electrode sub-portion and a second electrode sub-portion. The electrically conductive layer also includes (i) a first electrical contact pad in electrical communication with the first electrode sub-portion and configured to communicate an electrical response of the first electrical sub-portion to the test meter, and (ii) a second electrical contact pad in electrical communication with the second electrode sub-portion and configured to communicate an electrical response of the second electrical sub-portion to the test meter.Type: ApplicationFiled: August 30, 2010Publication date: March 1, 2012Applicant: Cilag GmbH InternationalInventors: Stephen Patrick BLYTHE, Leanne Mills, Stephen Mackintosh
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Publication number: 20110162978Abstract: A method and system is provided to allow for determination of substantially Hematocrit independent analyte concentration. In one example, an analyte measurement system is provided that includes a test strip and a test meter. The test strip includes a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer. The test meter includes an electronic circuit and a signal processor. The electronic circuit applies a plurality of voltages to the reference electrode and the working electrode over respective durations. The signal processor is configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes.Type: ApplicationFiled: January 22, 2010Publication date: July 7, 2011Applicant: LifeScan Scotland Ltd.Inventors: Marco F. CARDOSI, Stephen Patrick Blythe, Matthew Finch, Arlene Thompson, Nina Antonia Naylor, Eric Jason Bailey, Michael Patrick Dolan, Gretchen Anderson, Lorraine Comstock, Mary Mcevoy, Thomas Sutton, Richard Michael Day, Leanne Mills, Emma Vanessa Jayne Day, Christopher Philip Leach
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Publication number: 20110005941Abstract: A method for determining an analyte concentration in blood is described that reduces the effects of hematocrit using a test strip attached to a test meter. The test strip includes a working electrode and a reference electrode. The test meter applies a test voltage between the working electrode and the reference electrode. After a user applies a blood sample containing an analyte onto the test strip, the test meter measures a plurality of test currents for a test time interval.Type: ApplicationFiled: September 3, 2009Publication date: January 13, 2011Applicant: LifeScan Scotland Ltd.Inventors: Stephen Patrick BLYTHE, Marco F. Cardosi, Leanne Mills, Manuel Alvarez-Icaza, Emma Vanessa Jayne Day, Richard Michael Day, Christopher Philip Leach
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Publication number: 20100219084Abstract: Description is provided herein for an embodiment of a method determining a hematocrit-corrected glucose concentration. The exemplary method includes providing a test strip having a reference electrode and a working electrode, wherein the working electrode includes a plurality of microelectrodes and is coated with at least an enzyme and a mediator.Type: ApplicationFiled: October 5, 2007Publication date: September 2, 2010Inventors: Stephen Patrick Blythe, Marco F. Cardosi, Andrew Gill, Leanne Mills, Christopher Philip Leach
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Patent number: 7740801Abstract: A system for the determination of an analyte in a bodily fluid sample includes an analytical test strip and an analytical meter. The analytical test strip has a substrate layer, an electroluminescent component (either an electroluminescent module and/or an electroluminescent lamp) disposed on the substrate layer, and a sample chamber configured for receiving a bodily fluid sample disposed above the substrate layer. Moreover, the analytical meter is configured for insertion of the analytical test strip therein and subsequent determination of the analyte.Type: GrantFiled: October 31, 2006Date of Patent: June 22, 2010Assignee: LifeScan Scotland LimitedInventors: Selwayan Saini, Marco Fabio Cardosi, Leanne Mills, Stephen Patrick Blythe
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Publication number: 20080101984Abstract: A method for the determination of an analyte in a bodily fluid sample includes transferring a bodily fluid sample (such as a whole blood sample) to a sample chamber of an analytical test strip. The analytical test strip to which the bodily fluid sample is transferred has a substrate layer, an electroluminescent module disposed on the substrate layer and in optical communication with the sample chamber, and a fluorophore-containing photometric enzymatic reagent disposed within the sample chamber. In addition, the electroluminescent module is configured to emit light that facilitates a fluorescent chemical reaction sequence involving the fluorophore-containing photometric enzymatic reagent and the analyte.Type: ApplicationFiled: October 31, 2006Publication date: May 1, 2008Inventors: Selwayan Saini, Marco Fabio Cardosi, Leanne Mills, Stephen Patrick Blythe
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Publication number: 20080101986Abstract: An analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes a substrate layer, an electroluminescent module disposed on the substrate layer, a sample chamber configured for receiving the bodily fluid sample disposed above the substrate layer; and a fluorophore-containing photometric enzymatic reagent disposed within the sample chamber. Moreover, the electroluminescent module is in optical communication with the sample chamber and is configured to emit light that facilitates a fluorescent chemical reaction sequence involving the fluorophore-containing photometric enzymatic reagent and the analyte.Type: ApplicationFiled: October 31, 2006Publication date: May 1, 2008Inventors: Selwayan Saini, Marco Fabio Cardosi, Leanne Mills, Stephen Patrick Blythe
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Publication number: 20080101985Abstract: A system for the determination of an analyte in a bodily fluid sample includes an analytical test strip and an analytical meter. The analytical test strip has a substrate layer, an electroluminescent component (either an electroluminescent module and/or an electroluminescent lamp) disposed on the substrate layer, and a sample chamber configured for receiving a bodily fluid sample disposed above the substrate layer. Moreover, the analytical meter is configured for insertion of the analytical test strip therein and subsequent determination of the analyte.Type: ApplicationFiled: October 31, 2006Publication date: May 1, 2008Inventors: Selwayan Saini, Marco Fabio Cardosi, Leanne Mills, Stephen Patrick Blythe
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Publication number: 20080101987Abstract: An analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes a substrate layer, an electroluminescent lamp disposed on the substrate layer, a sample chamber configured for receiving the bodily fluid sample disposed above the substrate layer; and an enzymatic reagent disposed within the sample chamber. Moreover, the electroluminescent lamp is configured to emit light, the light being visible to a user of the analytical test strip and providing the user with spatial awareness of the analytical test strip.Type: ApplicationFiled: October 31, 2006Publication date: May 1, 2008Inventors: Selwayan Saini, Marco Fabio Cardosi, Leanne Mills, Stephen Patrick Blythe
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Publication number: 20080100689Abstract: A method for manufacturing an analytical test strip with an electroluminescent component (either an electroluminescent module and/or an electroluminescent lamp) includes sequentially applying to a substrate layer, a rear electrode layer disposed on the substrate layer, an electrically-insulating layer disposed over the rear electrode layer, a phosphor layer disposed over the electrically insulating layer, and a front electrode layer (at least a portion of which is translucent) disposed over the phosphor layer. The sequential application is accomplished such that it forms an electroluminescent component of the analytical test strip.Type: ApplicationFiled: October 31, 2006Publication date: May 1, 2008Inventors: Selwayan Saini, Marco Fabio Cardosi, Leanne Mills, Stephen Patrick Blythe