Abstract: A closed system for separately storing and selectively mixing two components, such as a drug and a diluent, under sterile conditions. The closed system can incorporate a drug vial of standard construction. A unique junction of the closed system permits a drug vial with a drug therein to be connected in a sterile manner with a compressible chamber having a diluent therein, after the drug and diluent have been separately sterilized. The junction encloses the end portions of access means to each of the receptacles, maintaining the end portions in sterile, spaced relation and providing for the selective establishment of a sterile pathway between the drug and diluent for mixing in a closed environment. The compressible chamber is of a unique design including gas-trapping and reservoir compartments in open communication. The compressible chamber is utilized with the junction to provide an efficient, sterile storage and mixing system.

Abstract: An administration port (14) for medical fluid containers (10) is provided which creates a proper seal with a broad dimensional range of cannulas. The port includes an inwardly tapered end 28 which can flex outwardly during insertion of a cannula (16). The inwardly tapered end 28 works in conjunction with an inner surface (32) of the sidewall (18) and end (28) to provide a unique sealing construction, to minimize friction between the port (14) and the cannula (16) during insertion of the cannula (16) and to inhibit inadvertent removal of the cannula. Selective removal of the associated cannula requires relatively little force, however.