Abstract: The present disclosure relates generally compositions and methods of using the same for the treatment of proteinopathies (e.g. Alpha-1-antitrypsin deficiency, Non-alcoholic fatty liver disease, Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, and Huntington's disease) with one or more proteotoxicity reducing agents.

Abstract: In some embodiments of the present invention, a disk drive includes a rotatable data storage disk, a head, and a controller. The head is configured to fly on an air cushion relative to a data recording surface of the rotating disk while writing data to the data recording surface responsive to a write command from a host device or while reading data from the data recording surface to generate a read signal responsive to a read command from the host device. The controller is configured to measure flying height of the head relative to the data recording surface of the disk in response to sensing power-up of the disk drive and/or a shut-down command from the host device. The controller may measure the flying height in response to sensing power-up of the disk drive and, subsequent to measuring the flying height, may generate a ready signal to the host computer that indicates that the disk drive has powered-up and is ready to receive read/write commands from the host computer.

Abstract: A disk drive measures the radial misposition of tracks and repositions the tracks at regularly spaced intervals. Written in runout (WRO) in servo bursts is determined to calculate track spacing and squeeze among adjacent tracks. Tracks with improper spacing are repositioned by adding a squeeze correction term to the servo wedges. Thereafter, when the disk drive operates to store data, the servo bursts are used to calculate a position error signal (PES), and the squeeze correction term is combined with the PES to position the head at a proper track radius.

Abstract: A disk drive measures the radial misposition of tracks and repositions the tracks at regularly spaced intervals. Written in runout (WRO) in servo bursts is determined to calculate track spacing and squeeze among adjacent tracks. Tracks with improper spacing are repositioned by adding a squeeze correction term to the servo wedges. Thereafter, when the disk drive operates to store data, the servo bursts are used to calculate a position error signal (PES), and the squeeze correction term is combined with the PES to position the head at a proper track radius.