Patents by Inventor Stephen R. Plymate

Stephen R. Plymate has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified Pyrrolo- and Pyrazolo- Pyrimidines for Prostate Cancer Therapy
    Publication number: 20230125057
    Abstract: This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases affected by glycolytic generation of adenosine triphosphate (ATP). More particularly, this disclosure relates to compounds and pharmaceutical compositions thereof, methods of selectively inhibiting glycolysis with these compounds, and methods of treating diseases that benefit from selective glycolysis inhibition, such as cancer.
    Type: Application
    Filed: January 7, 2021
    Publication date: April 20, 2023
    Inventors: Wesley C. VAN VOORHIS, Dustin James MALY, Kayode K. OJO, Gayani PERERA, Stephen R. PLYMATE, Cynthia SPRENGER, Takuma UO, Rama Subba Rao VIDADALA
  • Bumped kinase inhibitor compositions and methods for treating cancer
    Patent number: 10350211
    Abstract: The present disclosure is generally directed to bumped kinase inhibitor (BKI) compositions and methods for treating cancer.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: July 16, 2019
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Wesley C. Van Voorhis, Erkang Fan, Dustin James Maly, Kayode K. Ojo, Stephen R. Plymate, Rama Subba Rao Vidadala
  • BUMPED KINASE INHIBITOR COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20180271871
    Abstract: The present disclosure is generally directed to bumped kinase inhibitor (BKI) compositions and methods for treating cancer.
    Type: Application
    Filed: January 26, 2016
    Publication date: September 27, 2018
    Inventors: Wesley C. VAN VOORHIS, Erkang FAN, Dustin James MALY, Kayode K. OJO, Stephen R. PLYMATE, Rama Subba Rao VIDADALA
  • Identifying taxane sensitivity in prostate cancer patients
    Patent number: 9671405
    Abstract: The invention relates to detection and/or treatment of a subset of prostate cancer patients who may benefit from taxane treatment. The method comprises testing whether an androgen receptor (AR) splice variant is present in a test sample obtained from the patient, wherein the androgen receptor variant can be ARv5,6,7.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: June 6, 2017
    Assignees: Cornell University, University of Washington
    Inventors: Paraskevi Giannakakou, Stephen R. Plymate
  • IDENTIFYING TAXANE SENSITIVITY IN PROSTATE CANCER PATIENTS
    Publication number: 20150233927
    Abstract: The invention relates to detection and/or treatment of a subset of prostate cancer patients who may benefit from taxane treatment. The method comprises testing whether an androgen receptor (AR) splice variant is present in a test sample obtained from the patient, wherein the androgen receptor variant can be ARv5,6,7 or ARv7, or a combination thereof.
    Type: Application
    Filed: September 19, 2013
    Publication date: August 20, 2015
    Inventors: Paraskevi Giannakakou, Stephen R. Plymate
  • IGF-IR antagonists as adjuvants for treatment of prostate cancer
    Patent number: 7972600
    Abstract: The present invention relates to a method of treating prostate cancer with androgen deprivation therapy and an insulin-like growth factor receptor (IGF-IR) antagonist. Although the response rate of prostate cancer to androgen deprivation therapy (ADT) is high, surviving cancer cells invariably become androgen independent (AI) and tumor growth follows. The invention inhibits or delays transition of androgen dependent cancer to androgen independent cancer, significantly decreases risk of recurrence, and improves treatment outcome.
    Type: Grant
    Filed: February 5, 2007
    Date of Patent: July 5, 2011
    Assignees: ImClone LLC, University of Washington
    Inventors: Dale L. Ludwig, Stephen R. Plymate
  • IGF-IR antagonists as adjuvants for treatment of prostate cancer
    Publication number: 20090175868
    Abstract: The present invention relates to a method of treating prostate cancer with androgen deprivation therapy and an insulin-like growth factor receptor (IGF-IR) antagonist. Although the response rate of prostate cancer to androgen deprivation therapy (ADT) is high, surviving cancer cells invariably become androgen independent (AI) and tumor growth follows. The invention inhibits or delays transition of androgen dependent cancer to androgen independent cancer, significantly decreases risk of recurrence, and improves treatment outcome.
    Type: Application
    Filed: February 5, 2007
    Publication date: July 9, 2009
    Inventors: Dale L. Ludwig, Stephen R. Plymate
  • RECEPTOR ANTAGONISTS FOR TREATMENT OF METASTATIC BONE CANCER
    Publication number: 20090110678
    Abstract: The invention provides methods of treating bone cancer, particularly metastatic bone cancer, by administering an IGF-IR antagonist and/or a PDGFR? antagonist. The invention also provides antibodies that bind to human PDGFR? and neutralize activation of the receptor. The invention further provides a methods for neutralizing activation of PDGFR?, and a methods of treating a mammal with a neoplastic disease using the antibodie alone or in combination with other agents.
    Type: Application
    Filed: June 19, 2006
    Publication date: April 30, 2009
    Applicants: ImClone Systems Incorporated, University of Washington
    Inventors: Dale L. Ludwig, Stephen R. Plymate