Abstract: The present invention provides freebase and salt forms, and compositions and methods thereof, useful for treating various conditions in which aldehyde toxicity is implicated in the pathogenesis by the administration of small molecule therapeutics acting as a scavenger for toxic aldehydes.

Abstract: Embodiments support systems and methods for classifying and ranking headnote reports based on a query, and for outputting a highest ranked headnote in response to the query. In an aspect, headnote scores may be calculated for each headnote of a plurality of headnotes to determine a measure of correspondence between a given headnote and the query. In an aspect, a dataset including at least the query, the headnotes, and the headnote scores may be provided to and analyzed by a classifier to produce a set of classifications. In an aspect, the headnote scores and the set of classifications may be determined by at least one machine learning model. In an aspect, the classifications enable the ranking of the headnotes relative to one another, such that the highest ranked headnote may be the headnote most responsive to the query. In an aspect, a method may include outputting the highest ranked headnote.

Abstract: A planar overrunning coupling assembly for a geared transmission. The coupling assembly has a circular pocket plate, a notch plate, and torque transmitting struts in pockets formed in the pocket plate. The geometry of the pockets prevents displacement of the struts toward the notch plate under the influence of centrifugal force when the pocket plate overruns the notch plate. The pocket plate and the notch plate define in part friction disc coupling assemblies.

Abstract: A planar overrunning coupling assembly for a geared transmission. The coupling assembly has a circular pocket plate, a notch plate, and torque transmitting struts in pockets formed in the pocket plate. The geometry of the pockets prevents displacement of the struts toward the notch plate under the influence of centrifugal force when the pocket plate overruns the notch plate. The pocket plate and the notch plate define in part friction disc coupling assemblies.