Patents by Inventor Stephen S. Navran
Stephen S. Navran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10214715Abstract: A bioreactor system for stem cell expansion has a fluid-filled reactor chamber in which stem cells are cultured. The culture compartment of the reactor chamber is transversed by a perfusion core with multiple niche-like scaffolds positioned along the length of the perfusion core. The bioreactor system also uses a media gas exchange module that is free standing and does not require its inclusion in a CO2 incubator.Type: GrantFiled: March 5, 2015Date of Patent: February 26, 2019Assignee: Synthecon, Inc.Inventor: Stephen S. Navran, Jr.
-
Publication number: 20170204358Abstract: A bioreactor system for stem cell expansion has a fluid-filled reactor chamber in which stem cells are cultured. The culture compartment of the reactor chamber is transversed by a perfusion core with multiple niche-like scaffolds positioned along the length of the perfusion core. The bioreactor system also uses a media gas exchange module that is free standing and does not require its inclusion in a CO2 incubator.Type: ApplicationFiled: March 5, 2015Publication date: July 20, 2017Inventor: Stephen S. Navran, Jr.
-
Patent number: 8278101Abstract: A stem cell niche for expanding stem cells in culture is described. The stem cell niche includes a scaffold, a plurality of stromal mesenchymal stem cells, and a plurality of umbilical cord blood stem cells grown in a rotating culture chamber. One embodiment of the rotating culture chamber has a fluid-filled compartment in which the umbilical cord blood stem cells are grown in the presence of the mesenchymal stem cells seeded on the scaffold. The culture chamber has a dual flow valving member at each end, wherein a first flow path passes under a molecular cut-off membrane covering a central core that transverses the culture chamber and a second flow path flows through the culture chamber and allows cells to be harvested while in suspension.Type: GrantFiled: December 3, 2010Date of Patent: October 2, 2012Assignee: Synthecon, Inc.Inventor: Stephen S. Navran, Jr.
-
Publication number: 20110136226Abstract: A stem cell niche for expanding stem cells in culture is described. The stem cell niche includes a scaffold, a plurality of stromal mesenchymal stem cells, and a plurality of umbilical cord blood stem cells grown in a rotating culture chamber. One embodiment of the rotating culture chamber has a fluid-filled compartment in which the umbilical cord blood stem cells are grown in the presence of the mesenchymal stem cells seeded on the scaffold. The culture chamber has a dual flow valving member at each end, wherein a first flow path passes under a molecular cut-off membrane covering a central core that transverses the culture chamber and a second flow path flows through the culture chamber and allows cells to be harvested while in suspension.Type: ApplicationFiled: December 3, 2010Publication date: June 9, 2011Applicant: Synthecon, Inc.Inventor: Stephen S. Navran, JR.
-
Patent number: 7507581Abstract: A method for improving the health and viability of pancreatic islets and improving the outcome of pancreatic islet transplantations is described. The method includes incubating the islets with an IKVAV-containing laminin A chain peptide, such as PA22-2, either before or during the culturing of the islets in an RCCS bioreactor.Type: GrantFiled: April 3, 2006Date of Patent: March 24, 2009Assignee: Synthecon, Inc.Inventor: Stephen S. Navran, Jr.
-
Patent number: 7390653Abstract: The culture chamber of the present invention has a fluid-filled culture compartment in which cells, tissues and other biologicals are cultured. The culture compartment is transversed by one or more molecular weight cut-off membranes attached to a membrane carrier assembly. Incoming nutrients are transported through the membrane into the culture compartment and metabolic waste products are transported away from the fluid-filled culture compartment through the membrane and out the chamber outlet. Both reusable and disposable culture chambers are described for culturing cells, cell aggregates, particles, tissues and organoids.Type: GrantFiled: December 2, 2003Date of Patent: June 24, 2008Assignee: Synthecon, Inc.Inventors: Roger Akers, William J. Anderson, Adrian F. Dinges, Jr., Stephen S. Navran, Jr.
-
Patent number: 7144727Abstract: The bioreactor system of the present invention has two fluid-filled culture compartments in which cells, tissues and other biologicals are cultured. The two culture compartments are in fluid communication with each other and each culture compartment is transversed by a filter that prevents the exit of the cells from the culture compartment. Both reusable and disposable culture chambers are described for use as the first and/or second culture compartment.Type: GrantFiled: April 9, 2004Date of Patent: December 5, 2006Assignee: Synthecon, Inc.Inventors: Roger Akers, William J. Anderson, Stephen S. Navran, Jr.
-
Patent number: 6902909Abstract: A process has been developed for the production of human recombinant polypeptides using transformed mammalian cells cultured in a horizontally rotating culture vessel modulated to create low shear, high mass transfer conditions. The resulting recombinant polypeptide has bioactivity and is produced in increase amounts.Type: GrantFiled: July 7, 2003Date of Patent: June 7, 2005Assignee: Synthecon, Inc.Inventors: Stephen S. Navran, Jr., Roger Akers, William J. Anderson, Adrian F. Dinges, Jr.
-
Publication number: 20040203140Abstract: The bioreactor system of the present invention has two fluid-filled culture compartments in which cells, tissues and other biologicals are cultured. The two culture compartments are in fluid communication with each other and each culture compartment is transversed by a filter that prevents the exit of the cells from the culture compartment. Both reusable and disposable culture chambers are described for use as the first and/or second culture compartment.Type: ApplicationFiled: April 9, 2004Publication date: October 14, 2004Applicant: Synthecon, Inc.Inventors: Roger Akers, William J. Anderson, Stephen S. Navran
-
Publication number: 20040110273Abstract: The culture chamber of the present invention has a fluid-filled culture compartment in which cells, tissues and other biologicals are cultured. The culture compartment is transversed by one or more molecular weight cut-off membranes attached to a membrane carrier assembly. Incoming nutrients are transported through the membrane into the culture compartment and metabolic waste products are transported away from the fluid-filled culture compartment through the membrane and out the chamber outlet. Both reusable and disposable culture chambers are described for culturing cells, cell aggregates, particles, tissues and organoids.Type: ApplicationFiled: December 2, 2003Publication date: June 10, 2004Applicant: Synthecon, Inc.Inventors: Roger Akers, William J. Anderson, Adrian F. Dinges, Stephen S. Navran
-
Publication number: 20040014177Abstract: A process has been developed for the production of human recombinant polypeptides using transformed mammalian cells cultured in a horizontally rotating culture vessel modulated to create low shear, high mass transfer conditions. The resulting recombinant polypeptide has bioactivity and is produced in increase amounts.Type: ApplicationFiled: July 7, 2003Publication date: January 22, 2004Applicant: Synthecon, Inc.Inventors: Stephen S. Navran, Roger Akers, William J. Anderson, Adrian F. Dinges
-
Patent number: 6673598Abstract: A cell culture bag for culturing cells, cellular aggregates, particles, tissues and organoids is disclosed. The cell culture bag is a flexible and disposable culture bag that fits within a bag support chamber of a bioreactor. The cell culture bag has an inlet means and an outlet means for the introduction and removal of media. Certain embodiments of the culture bag have an inlet and outlet fluid coupling swivel joint and/or perforated perfusion tubes extending from the inlet means into the interior of the bag to assist in mass transfer and mixing the media to maintain an even temperature throughout the culture bag.Type: GrantFiled: October 29, 2002Date of Patent: January 6, 2004Assignee: Synthecon, Inc.Inventors: Roger Akers, William J. Anderson, Stephen S. Navran, Jr., Adrian F. Dinges, Jr.