Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods useful for treating solid tumors. In a specific embodiment, a method for treating a solid tumor in a patient having cancer comprises the step of administering to the patient a demethylating agent, a histone deacetylase (HDAC) inhibitor and a checkpoint inhibitor.

Abstract: An air cleaner assembly can contain an air filter element to filter contaminant material out of an air stream. In some examples, the air cleaner assembly includes a housing with an integrated noise suppression chamber for supplying air to a downstream compressor. The housing forms a cavity into which an air filter element is inserted. Contaminated air enters the housing and passes through the air filter. Filtered air can discharge from the housing through a first opening supplying air to a combustion engine and a second opening supplying air to a compressor. Air supplied to the compressor passes from the interior of the housing containing the filter element and through the integrated noise suppression chamber before being discharged. The acoustic energy released by the filtered air stream exiting the air cleaner assembly may be reduced by passing through the noise suppression chamber.

Abstract: A diesel exhaust fluid (DEF) storage system may include a reservoir body having a magnet integrally formed about an inlet opening of the reservoir body. For example, the magnet may be molding about a perimeter of the inlet opening during a molding process in which the reservoir body is formed. In some examples, the inlet opening defines a lumen extending into an interior of the reservoir body with the magnet being positioned at a location along the lumen opposite an external end face. The position of the magnet may be effective to engage a corresponding magnet on a DEF fill nozzle, allowing DEF to be introduced into the reservoir body. By integrating the magnet into the reservoir body, protection features that prevent erroneous filling of the reservoir body cannot be removed or bypassed.

Abstract: An air cleaner assembly can contain an air filter element to filter contaminant material out of an air stream. In some examples, the air cleaner assembly includes a housing with an integrated noise suppression chamber for supplying air to a downstream compressor. The housing forms a cavity into which an air filter element is inserted. Contaminated air enters the housing and passes through the air filter. Filtered air can discharge from the housing through a first opening supplying air to a combustion engine and a second opening supplying air to a compressor. Air supplied to the compressor passes from the interior of the housing containing the filter element and through the integrated noise suppression chamber before being discharged. The acoustic energy released by the filtered air stream exiting the air cleaner assembly may be reduced by passing through the noise suppression chamber.

Abstract: A safety mailbox assembly, comprising: a substantially hollow and post-less top structure configured with a top portion of a reversible connection at a base of the top structure and including at least one mail box disposed therein; a substantially hollow and post-less bottom structure configured with a bottom portion of the reversible connection; wherein the top portion and the bottom portion connect together to reversibly connect the top structure and the bottom structure.

Abstract: A diesel exhaust fluid (DEF) storage system may include a reservoir body having a magnet integrally formed about an inlet opening of the reservoir body. For example, the magnet may be molding about a perimeter of the inlet opening during a molding process in which the reservoir body is formed. In some examples, the inlet opening defines a lumen extending into an interior of the reservoir body with the magnet being positioned at a location along the lumen opposite an external end face. The position of the magnet may be effective to engage a corresponding magnet on a DEF fill nozzle, allowing DEF to be introduced into the reservoir body. By integrating the magnet into the reservoir body, protection features that prevent erroneous filling of the reservoir body cannot be removed or bypassed.

Abstract: A safety mailbox assembly, comprising: a substantially hollow and post-less top structure configured with a top portion of a reversible connection at a base of the top structure and including at least one mail box disposed therein; a substantially hollow and post-less bottom structure configured with a bottom portion of the reversible connection; wherein the top portion and the bottom portion connect together to reversibly connect the top structure and the bottom structure.

Abstract: Disclosed herein is a method for purging water in a waterpark reservoir by inducing a siphon and several examples of an apparatus to achieve this result. The apparatus disclosed herein provides an emptying mechanism which may have no moving parts or valves between the inlet and the outlet and yet delivers a short term large volume dump or purge of water to patrons in an impact area of a patron region of a waterpark.

Abstract: Disclosed herein is a method for purging water in a waterpark reservoir by inducing a siphon and several examples of an apparatus to achieve this result. The apparatus disclosed herein provides an emptying mechanism which may have no moving parts or valves between the inlet and the outlet and yet delivers a short term large volume dump or purge of water to patrons in an impact area of a patron region of a waterpark.

Abstract: Disclosed herein is a method for purging water in a waterpark reservoir by inducing a siphon and several examples of an apparatus to achieve this result. The apparatus disclosed herein provides an emptying mechanism which may have no moving parts or valves between the inlet and the outlet and yet delivers a short term large volume dump or purge of water to patrons in an impact area of a patron region of a waterpark.

Abstract: Disclosed herein is a method for purging water in a waterpark reservoir by inducing a siphon and several examples of an apparatus to achieve this result. The apparatus disclosed herein provides an emptying mechanism which may have no moving parts or valves between the inlet and the outlet and yet delivers a short term large volume dump or purge of water to patrons in an impact area of a patron region of a waterpark.

Abstract: An apparatus for transferring thermal energy to or from a battery cell is disclosed, which includes a thermally conductive plate enclosing a conduit in communication with an inlet for receiving a heat transfer fluid stream and being configured to cause the fluid to flow through the plate to an outlet. The plate has a surface for receiving thermal energy generated by operation of the battery cell and is operable to couple thermal energy to the fluid. In one aspect the plate includes first and second opposing walls and the conduit includes a first conduit portion formed in the first wall and a second corresponding conduit portion formed in the second wall defining the conduit. In another aspect the conduit includes an aperture in a central wall and first and second cover walls on either side of the central wall. The cover walls enclose aperture and provide a seal.

Abstract: A banking system is controlled responsive to data read from data bearing records. The banking system includes an automated banking machine. The machine is operable to carry out a financial transaction for a person responsive to a determination that the person is an authorized user of the machine based on correspondence between identifying data read by a reader of the machine and data store information. The machine includes a check acceptor that is operative to receive checks from authorized machine users. The check acceptor is operable to continuously move a received check along its transport path while simultaneously rotationally orienting the check into alignment with the transport path. A check determined not to have at least one property of an acceptable check is returned to the machine user. Acceptable checks are processed and stored in the machine.

Abstract: An automated banking machine controlled responsive to data bearing records includes a card reader that is operative to read data from user cards including identifying data and to authorize operation of an automated banking machine responsive to the identifying data. The automated banking machine includes a deposit accepting device. The deposit accepting device is operative to receive a stack of sheets and to separate each sheet from the stack through operation of a picker. Each sheet is aligned with the sheet path and analyzed by analysis devices including at least one magnetic read head, an imager and/or a validation device. Sheets determined not to have at least one property of a genuine sheet are returned to a user of the machine. Sheets determined to have at least one property of genuine sheets are processed and stored in the machine.

Abstract: A system, method, and apparatus infrastructure provide real time wireless tracking of multiple initial data parameters transmitted from individual mobile receiving or system units installed in customer vehicles. A management network receives and decodes initial data parameters from respective receiving mobile units, matches and encodes the same according to stored predetermined customer specified format preferences, and transmits customer specified data streams to customers. An additional step correlates the received specified-data streams with additional public-supplied data or third-party contractually supplied data to provide an enhanced customer report enabling a number of reports; including a credibility determination between the public-supplied data and the received specified-data, a customer vehicle travel efficiency report, a safe operation vehicle report, and a vehicle operator effectiveness report.

Abstract: A banking machine system controlled by data bearing records includes an automated banking machine which includes a deposit accepting device. Data read from a user card through operation of a card reader in the machine is used to determine if the data on the card corresponds to an authorized machine user. The deposit accepting device is operative to receive a stack of sheets and to separate each sheet from the stack through operation of a picker. Each sheet is aligned with the sheet path and analyzed by analysis devices including at least one magnetic read head, an imager and/or a validation device. Sheets determined not to have at least one property of a genuine sheet are returned to a user of the machine. Sheets determined to have at least one property of genuine sheets are processed and stored in the machine.

Abstract: An automated banking machine controlled responsive to data bearing records includes a card reader that is operative to read data from user cards including identifying data and to authorize operation of an automated banking machine responsive to the identifying data. The automated banking machine includes a deposit accepting device. The deposit accepting device is operative to receive a stack of sheets and to separate each sheet from the stack through operation of a picker. Each sheet is aligned with the sheet path and analyzed by analysis devices including at least one magnetic read head, an imager and/or a validation device. Sheets determined not to have at least one property of a genuine sheet are returned to a user of the machine. Sheets determined to have at least one property of genuine sheets are processed and stored in the machine.

Abstract: A banking machine system controlled by data bearing records includes an automated banking machine which includes a deposit accepting device. Data read from a user card through operation of a card reader in the machine is used to determine if the data on the card corresponds to an authorized machine user. The deposit accepting device is operative to receive a stack of sheets and to separate each sheet from the stack through operation of a picker. Each sheet is aligned with the sheet path and analyzed by analysis devices including at least one magnetic read head, an imager and/or a validation device. Sheets determined not to have at least one property of a genuine sheet are returned to a user of the machine. Sheets determined to have at least one property of genuine sheets are processed and stored in the machine.

Abstract: A turbomachine has a number of interspersed stages of rotor blades and stator vanes. A split case has first and second case sections meeting along a junction extending essentially along a longitudinal first plane. The metallic spring seal extends along the junction. The spring seal may be installed in a remanufacturing of an existing turbomachine.

Abstract: The present invention provides a high speed, multi-ported, direct data flow memory architecture that employs memory width and speed greater than system bus width and speed to allow shallow burst depth and reduce other-port latencies, while maintaining multi-port throughput. The inventive system has a data storage device (SDRAM) and a multiplexer connected to the SDRAM. Two or more interfaces or ports are provided with data sourcing controllers respectively connected to the interfaces. A communications bus connects the SDRAM to the data sourcing controllers for facilitating data communications. A FIFO buffer memory is located between the multiplexer and the data sourcing controllers. The need for retries is eliminated and host bus widths are matched to memory data width. Read-ahead algorithms are provided that adapt the larger system bus burst sizes to the smaller memory burst sizes with the ability to cancel unneeded advance requests for data.