Abstract: A dose counter for a metered dose inhaler has an activation valve at a valve end of the metered dose inhaler. The dose counter includes a housing having a first end and an opposing second end. The first end receives a metered dose inhaler valve end, and the second end defines a cavity. An actuation detection assembly in the cavity includes an actuation detection element on the second end of the housing, and an activator element in the cavity of the housing. The activator element is configured to move between a first position in the cavity in which the activator element is spaced apart from the actuation detection element on the housing by a gap and a second position in which the activator element cooperates with the actuation detection element so that the actuation detection element generates an actuation signal.

Abstract: A dose counter for a metered dose inhaler has an activation valve at a valve end of the metered dose inhaler. The dose counter includes a housing having a first end and an opposing second end. The first end receives a metered dose inhaler valve end, and the second end defines a cavity. An actuation detection assembly in the cavity includes an actuation detection element on the second end of the housing, and an activator element in the cavity of the housing. The activator element is configured to move between a first position in the cavity in which the activator element is spaced apart from the actuation detection element on the housing by a gap and a second position in which the activator element cooperates with the actuation detection element so that the actuation detection element generates an actuation signal.

Abstract: Aspects of the invention relate to an applicator, and methods of use thereof, which can house multiple component formulations in separate material receptacles, which components can then be easily combined at the time of use without assembly by the user. In certain embodiments, a device of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, or any of the internal tissues. In certain embodiments, a device of the invention can be configured to apply a spray or a stream of a liquid formulation to a surface. In certain embodiments, a device of the invention can be configured to deliver the formulation through an endoscope or laparoscope.