Abstract: The invention relates to a process for preparing heterocyclic amide derivatives, to novel polymorphic forms obtained from said process and the use of said polymorphic forms for use in the treatment and prophylaxis of cancer.

Abstract: Methods, systems, and apparatus for supporting uplink Transmission Time Interval (TTI) bundling in Long Term Evolution (LTE) are provided. Methods, systems, and apparatus for signaling, activation/deactivation, and wireless transmit/receive unit (WTRU) behavior are also provided. In an example, a downlink control information (DCI) associated with a repeated physical uplink shared channel (PUSCH) transmission may be received. A hybrid acknowledgment repeat request (HARQ) process information may be determined using the received DCI. A repeated PUSCH transmission may be sent in accordance with one or more time units, the repetition configuration, and the HARQ process information.

Abstract: An ultracapacitor module may include an ultracapacitor cell stack containing one or more ultracapacitor cells. An ultracapacitor module may include a bidirectional boost/buck DC/DC converter. The ultracapacitor cell stack and the DC/DC converter may be configured to be connected in series with a voltage supply bus of a vehicle. An ultracapacitor module may include a voltage sensor configured to determine an operating voltage of the voltage supply bus. An ultracapacitor module may include an electronic controller in electrical communication with the DC/DC converter and the voltage sensor. The electronic controller may be configured to control the DC/DC converter such that the ultracapacitor cell stack operates in a voltage range that is 20 to 80 percent of the operating voltage of the voltage supply bus.

Abstract: Methods, systems, and computer-readable media for generating a statistically covaried machine learning model for performance measurement of service providers. The method receives a configuration file that includes one or more parameters associated with a plurality of individuals and parses it to generate and executing the database query on input data to generate sets of tabulated data of individuals of the plurality of individuals. The method next determines one or more measures of service providers listed in the configuration file using two or more tabulated data of individuals from the sets of tabulated data of individuals. The method finally generates a covaried machine learning model by training a machine learning model by statistically covarying measures and using them as training data.

Abstract: T cells expressing a chimeric antigen receptor and a T cell receptor specific for CMV (bi-specific T cells) are described as a methods for using such cells in immunotherapy. In the immunotherapy methods, the recipient can be exposed to a CMV vaccine in order to expand and/or stimulate the be-specific T cells.

Abstract: The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.

Abstract: Systems and methods for deployment on an autonomous vehicle are provided. In some example embodiments, the system includes a first compute unit and a second compute unit, in which the first compute unit is configured to receive first information of the vehicle and an environment of the vehicle, generate a first control command based on the first information, and transmit the first control command to a controller of the vehicle to effectuate an autonomous operation of the vehicle; and the second compute unit is configured to receive second information of the vehicle and the environment of the vehicle, generate a second control command based on the second information, and only when a fault or failure of the first compute unit is detected, transmits the second control command to the controller of the vehicle to effectuate the autonomous operation of the vehicle.

Abstract: Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3 ? signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.

Abstract: The disclosure provides an apparatus for high throughput analysis of samples and a method of making an assay card and performing an assay using the apparatus. The apparatus can include a transporter to position and advance a first plate of the QMAX card, a first dispenser to deposit a sample on the first plate, a second dispenser to dispense a reagent to contact the sample, a press to compress the sample between the first and second plates of the QMAX card into a uniformly thick layer, and an imager to image the uniformly thick layer.

Abstract: Presented are embedded control systems with logic for computation and data sharing, methods for making/using such systems, and vehicles with distributed sensors and embedded processing hardware for provisioning automated driving functionality. A method for operating embedded controllers connected with distributed sensors includes receiving a first data stream from a first sensor via a first embedded controller, and storing the first data stream with a first timestamp and data lifespan via a shared data buffer in a memory device. A second data stream is received from a second sensor via a second embedded controller. A timing impact of the second data stream is calculated based on the corresponding timestamp and data lifespan. Upon determining that the timing impact does not violate a timing constraint, the first data stream is purged from memory and the second data stream is stored with a second timestamp and data lifespan in the memory device.

Abstract: The present technology relates to depots for the treatment of postoperative pain via sustained, controlled release of a therapeutic agent. In some embodiments, the depot may comprise a therapeutic region comprising an analgesic, and a control region comprising a bioresorbable polymer and a releasing agent mixed with the polymer. The releasing agent may be configured to dissolve when the depot is placed in vivo to form diffusion openings in the control region. The depot may be configured to be implanted at a treatment site in vivo and, while implanted, release the therapeutic agent at the treatment site for no less than 3 days.

Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Abstract: A fibrous structure. The structure may include a plurality of continuous or semi-continuous knuckles extending from portions of the surface of the fibrous structure in a parallel path, wherein the plurality of knuckles may be separated by adjacent continuous or semi-continuous pillows. Each knuckle may comprise a plurality of discrete pillows, the plurality of discrete pillows may be arranged in a spaced configuration along the path of each knuckle; alternatively, each pillow may comprise a plurality of discrete knuckles, the plurality of discrete knuckles may be arranged in a spaced configuration along the path of each pillow.

Abstract: A turbine blade includes an airfoil section, wherein at least one cooling hole is formed a tip floor of the airfoil section, which is fluidically connected to an internal coolant cavity of the airfoil section. The turbine blade further includes an additively manufactured tip cap formed via layer-by-layer deposition of material directly over the tip floor of the airfoil section. The tip cap includes at least one squealer tip rail extending outward from the tip floor. The at least one squealer tip rail comprises an embedded cooling channel formed therein. The embedded cooling channel is aligned with and fluidically connected to the at least one cooling hole formed through the tip floor of the airfoil section. The embedded cooling channel comprises one or more outlets located on at least one of a side face and a top face of the at least one squealer tip rail.

Abstract: A vehicle detection system warns snowmobilers of other approaching vehicles with potential risk of collision. To better prevent accidents, the system calculates collision risks and warns the rider based on level of risk. When riding in groups, a member can press a stop request button to ask the group to slow down. When a member exits the group, everyone in the group will receive a message, alerts or indication with the update. The vehicle detection system utilizes Bluetooth® low energy (BLE), LoRaWAN® technologies and/or global positioning system technologies and is designed to detect other devices in the region and use acquired information to calculate proximity and risk of collision.

Abstract: A flavor or aroma charcoal material, such as charcoal briquets, which is formulated to include a flavor or aroma component. The charcoal material may include a smoldering agent (e.g., limestone), wood particles (e.g., sawdust), a binder, and the flavor or aroma component (herbs and/or spices). The flavor or aroma charcoal material may not be configured as a fuel charcoal material, for example, it may be substantially void of char and/or coal. In an embodiment, the flavor or aroma charcoal material may be provided as part of a blend of different charcoal materials that includes both flavor or aroma briquets in combination with fuel briquets (e.g., which fuel briquets include char and/or coal, while the flavor briquets do not). The flavor briquets provide enhanced aroma and/or flavor to the grilling experience.

Abstract: Provided herein are exemplary embodiments including a computer-implemented method of using artificial intelligence for automatically collecting and enriching network data for a smart campaign with autopilot features. The method includes, collecting a set of network data relevant to a smart campaign with autopilot features, applying one or more transformations to the collected set of data to create a modified set of data, generating from the modified set of data, enriched network data for a smart campaign with autopilot features, the enriched network data having content, context and event data, and using the enriched data to deploy a personalized campaign by identifying an audience, time, channel, content and goal of the communication.

Abstract: Systems and methods are described for merging customer profiles, such as may be implemented by a computer-implemented contact center service. In some aspects, a subset of profiles may be determined that satisfy merging criteria, where individual profiles include a plurality of data fields. At least one value in a first data field that conflicts between at least two profiles may be identified. Next a merged value may be selected for the first data field based on data deduplication criteria, where the data deduplication criteria includes at least one indicator of accuracy of values of the plurality of data fields. As a result of a determination that at least the subset of profiles of the group of profiles meet the merging criteria, at least the subset of profiles may be combined into a combined profile using the merged value.

Abstract: A method including the step contacting an olefin, an alcohol, a metallosilicate catalyst and a solvent, wherein the solvent comprises structure (I): wherein R1 and R2 are each selected from the group consisting of an aryl group and an alkyl group with the proviso that at least one of R1 and R2 is an aryl group, further wherein n is 1-3.

Abstract: The present disclosure relates to HIF-2? inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2? scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.