Abstract: The invention is directed to pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.

Abstract: The invention is directed to 3-?-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.

Abstract: The invention is directed to 5-amino-3-(3?-deoxy-?-D-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione prodrugs, whose metabolized parent compound has immunomodulatory activity. The invention also relates to the therapeutic use of such prodrugs and pharmaceutical compositions thereof in treating disease states associated with abnormal cell growth, such as cancer.

Abstract: The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.

Abstract: The invention is directed to carbonate and carbamate prodrugs of thiazolo[4,5-d]pyrimidine compounds, whose metabolized parent compound has immunomodulatory activity. The invention also relates to the therapeutic use of such prodrugs and pharmaceutical compositions thereof in treating disease states associated with abnormal cell growth, such as cancer.

Abstract: A protective flexible car cover that is attachable to and detachable from a foldable deployment rod, which facilitates deploying and removing the car cover from a vehicle, is disclosed. The attachment of the car cover to the deployment rod is effected by fasteners. The car cover has magnets or weights around its periphery to help hold the cover in place while being deployed and after deployment. Additional panels on the underside of the car cover and at the rear of the car cover are provided which can be held in place by the side doors of the vehicle or by the trunk lid.

Abstract: A protective flexible car cover which is designed to be attached and detached to a foldable deployment rod which facilitates deploying and removing the car cover without any motorized aids and which also provides for convenient storage of the car cover when it is not in use. The attachment of the car cover to the deployment rod is conveniently effected by a material like Velcro®. The car cover has magnets or weights around its periphery to help hold the cover in place while being deployed and after deployment. Additional panels on the underside of the car cover and at the rear of the car cover are provided which can be held in place by the side doors of the vehicle or by the trunk lid or rear door of the vehicle.

Abstract: A method and system for fabricating molded composite support members for use in climbing structures, which molded composite support members comprise variable performance properties along a longitudinal length thereof. The variable performance properties are achieved or provided by selectively reinforcing one or more regions determined to be subject to greater stress, thus allowing a minimum amount of material to be used in other areas that will subject to less structural stress. Selective reinforcement is accomplished by adapting one or more regions of a primary composite material composition with a supplemental composite material composition, wherein the supplemental composite material composition increases the amount of composite material fibers within that particular region.

Abstract: There are provided compounds of the formula I wherein R, V1, V2 and Ring A are described herein. The compounds exhibit anticancer activity.

Abstract: The present invention relates to a process for the preparation of the title compound, 5-amino-3H-thiazolo[4,5-d]pyrimidin-2-one, which is a useful intermediate in the preparation of certain thiazolo[4,5-d]pyrimidine nucleosides, which can have utility as immunomodulators.

Abstract: Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

Abstract: There are presented compounds of the formula or pharmaceutically acceptable salts thereof, wherein Y1, Y2, X1, X2, X3 and R are as described in this application. These compounds are believed to inhibit MDM2-p53 interaction and as such the compounds will have anti-hyperproliferative cellular activity.

Abstract: The invention is directed to pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.

Abstract: The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and pharmaceutical compositions containing them, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds and prodrugs.

Abstract: Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.

Abstract: A molding process, other than pultrusion, is used to manufacture composite ladder rails of non-uniform cross-sectional area and non-uniform strength throughout their lengths. Each ladder rail includes a structural fiber preform embedded in a cured polymeric resin. Fiberglass preforms are preferred because they are electrically non-conductive. Resin transfer molding processes, using either polyester or epoxy resins, are ideally suited for such manufacture. Vacuum-bagged, open-mold processes may also be used, as may be compression molding processes. Regions of the rails subject to greater stress during usage are strategically reinforced with additional structural fibers, and have greater cross-sectional area than regions subjected to lesser stress. The differential cross-sectional area permits the construction of ladders which are optimized for both strength and lightness of weight. Ladders of all types may be constructed with rails incorporating the invention.

Abstract: Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. As cancer therapeutics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation.

Abstract: and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3, Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.

Abstract: Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

Abstract: The invention is directed to 3-?-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.