Abstract: Disclosed is a novel CT denoising method using deep learning to boost the image signal-to-noise ratio for improved disease detection in patients with acute ischemic stroke (AIS). This method reduced the original CT image noise significantly better than BM3D, with SNR improvements in GM, WM, and DG by 2.47×, 2.83×, and 2.64× respectively and CNR improvements in DG/WM and GM/WM by 2.30× and 2.16× respectively. Scans denoised by the proposed model are shown to be visually clearer with preserved anatomy. The disclosed deep learning model significantly reduces image noise and improves signal-to-noise and contrast-to-noise ratios in 380 unseen head NCCT cases.

Abstract: Various aspects of the subject technology relate to systems, methods, and machine-readable media for providing an application trusted execution environment. Various aspects may include performing attestation of each application enclave of a plurality of application enclaves for a plurality of applications. Aspects may also include receiving a request from a client. Aspects may also include selecting a load balancer to forward the request to the application enclaves. Aspects may also include determining a sensitivity level of the request that is associated with a secured environment parameter. Aspects may include routing, by an enclave server of the load balancer, the request to an application enclave according to the sensitivity level for execution of an application of the plurality of applications in the application trusted execution environment.

Abstract: Systems of the present disclosure may ingest content from a plurality of data sources with the content including ingested documents referencing entities and events relevant to the ESG signals. The content may be stored in a content database. The System may also identify metadata and a body of text associated with each document to produce a set of preprocessed documents. An entity may be tagged to a first preprocessed document from the set of preprocessed documents, and the document may include a first document identifier. The System may generate an event score related to a first ESG signal including a direction and a magnitude associated with an event identified in the body of text. The event score may be tagged to the document. The system may write to an unstructured data set the document identifier in association with the tagged entity and the tagged event score for delivery.

Abstract: The invention provides novel, simple, reliable and effective methods for separating various lipids from biological samples. In certain embodiments, the invention provides HILIC-based UHPLC separation methods. In one embodiment, the methods of the invention offer an efficient and rapid separation of ether glycophospholipids (e.g., plasmalogens) from their diacyl or monoacyl counterparts within the same lipid class. In certain instances, the invention relates to the use of a Waters ACQUITY UPLC® system.

Abstract: The invention provides novel, simple, reliable and effective methods for separating various lipids from biological samples. In certain embodiments, the invention provides HILIC-based UHPLC separation methods. In one embodiment, the methods of the invention offer an efficient and rapid separation of ether glycophospholipids (e.g., plasmalogens) from their diacyl or monoacyl counterparts within the same lipid class. In certain instances, the invention relates to the use of a Waters ACQUITY UPLC® system.

Abstract: Subcortical neural structures are classified during a microelectrode recording (MER) procedure. As the electrode traverses subcortical structures toward a target neural structure, neural activity is analyzed. The neural activity is converted to electrical signals. Features pertaining to characteristics of the neural activity are extracted from the electrical signals. The features are synergistically combined using fuzzy clustering logic, for example. In an example embodiment, the combined results are provided in a form of a color coded map indicating the different structural regions traversed. Observation of the map provides an objective indication of the demarcations of the various structural regions traversed and an objective technique for classifying the structural regions.

Abstract: An interconnect structure, an interconnect structure for interconnecting first and second components, an interconnect structure for interconnecting a multiple component stack and a substrate, and a method of fabricating an interconnect structure. The interconnect structure comprising a base portion formed on a mounting surface of a first component; a pillar portion extending from the base portion and substantially perpendicularly to the mounting surface; and a head portion formed on the pillar portion and having larger lateral dimensions than the pillar portion; wherein the base portion and the pillar portion are integrally formed of a homogeneous material.

Abstract: An interconnect structure, an interconnect structure for interconnecting first and second components, an interconnect structure for interconnecting a multiple component stack and a substrate, and a method of fabricating an interconnect structure. The interconnect structure comprising a base portion formed on a mounting surface of a first component; a pillar portion extending from the base portion and substantially perpendicularly to the mounting surface; and a head portion formed on the pillar portion and having larger lateral dimensions than the pillar portion; wherein the base portion and the pillar portion are integrally formed of a homogeneous material.

Abstract: Subcortical neural structures are classified during a microelectrode recording (MER) procedure. As the electrode traverses subcortical structures toward a target neural structure, neural activity is analyzed. The neural activity is converted to electrical signals. Features pertaining to characteristics of the neural activity are extracted from the electrical signals. The features are synergistically combined using fuzzy clustering logic, for example. In an example embodiment, the combined results are provided in a form of a color coded map indicating the different structural regions traversed. Observation of the map provides an objective indication of the demarcations of the various structural regions traversed and an objective technique for classifying the structural regions.

Abstract: A substrate for power decoupling and a method of forming a substrate for power decoupling. The substrate comprises one or more decoupling capacitors; and one or more interconnections to the decoupling capacitors. At least one of the interconnections comprises a lossy material.

Abstract: A method, system, and computer readable medium for enabling a user within an application to select a time zone for a temporary period of time include selecting a temporary time zone having a start time and an end time, and changing a time of events that fall within the temporary time zone.

Abstract: A method and system for storing user-specific information in a centralized database and reducing data entry by intelligently determining what data is already stored in the centralized database and what data needs to be collected from the user. The method includes receiving a request from a user of a user computing system to initiate a transaction, wherein the transaction requires user-specific information in at least one associated field to complete the transaction, and receiving a request from a service provider system for the user-specific information.

Abstract: A method, computer readable medium, and system for scheduling and completing a reservation includes receiving at least one query for a dynamic event where the query comprises category criteria and date criteria. A dynamic set of one or more options which satisfy the category criteria and the date criteria in the query are identified in real time. Each of the identified dynamic options are entered and displayed in real time.

Abstract: The present invention provides for compounds of formula (I), (Ia) and (Ib) Wherein: A is selected from C—X and N, B is selected from C—Y and N, R1 is selected from H and (C1-C6)alkyl, R2 is selected from H and (C1-C6)alkyl, X is selected from H, HO, C(O)NH2, NH2 Y is selected from H, HO, NH2, Br, Cl and F Z is selected from H, HO F, CONH2 and CN; And pharmaceutically acceptable salts, solvates and prodrugs thereof; With the provisos that: for a compound of formula (I), (Ia) or (Ib), when A is C—X, B is C—Y, R1 is H or (C1-C6)alkyl and R2 is H or (C1-C6)alkyl at least one of X, Y and Z must be OH; for a compound of formula (I), when A is C—X and B is C—Y, Y is H, Z is H, R1 is H and R2 is H, then X cannot be OH; these compounds are useful as a medicament.

Abstract: Methods and apparatus are provided for the automated analysis of images of living cells acquired by time-lapse microscopy. The new methods and apparatus can be used for the segmentation, classification and tracking of individual cells in a cell population, and for the extraction of biologically significant features from the cell images. Based upon certain extracted features, the inventive image analysis methods can characterize a cell as mitotic or interphase and/or can classify a cell into one of the following mitotic phases: prophase, metaphase, arrested metaphase, and anaphase with high accuracy.

Abstract: The use of a composition comprising a selective dopamine D3 receptor agonist, wherein said dopamine D3 receptor agonist is at least about 15-times more functionally selective for a dopamine D3 receptor as compared with a dopamine D2 receptor when measured using the same functional assay, in the preparation of a medicament for the treatment and/or prevention of sexual dysfunction.

Abstract: A method of simultaneously bonding components, comprising the following steps. At least first, second and third components are provided and comprise: at least one glass component; and at least one conductive or semiconductive material component. The order of stacking of the components is determined to establish interfaces between the adjacent components. A hydrogen-free amorphous film is applied to one of the component surfaces at each interface comprising an adjacent: glass component; and conductive or semiconductive component. A sol gel with or without alkaline ions film is applied to one of the component surfaces at each interface comprising an adjacent: conductive or semiconductive component; and conductive or semiconductive component. The components are simultaneously anodically bonded in the determined order of stacking.

Abstract: A dynamic collaborative-browsing system enables client programs connected to a computer network to join and leave groups or sessions, to collaboratively browse together as a session, to communicate with other client programs in the session. Each client program in the session may act as a session leader, or may just follow a session leader as it browses network sites of the computer network. The system includes client programs, typically executing on client computers and server software, typically executing on one or more main servers. Network servers, such as Web servers, host a number of network sites each having a location or uniform resource locator (URL). The main server groups into server-defined cells.

Abstract: A Web-based authentication system and method, the system comprising at least one Web client station, at least one Web server station and an authentication center. The Web client station is linked to a Web cloud, and provides selected biometric data of an individual who is using the Web client station. The Web server station is also linked to the Web cloud. The authentication center is linked to at least one of the Web client and Web server stations so as to receive the biometric data. The authentication center, having records of one or more enrolled individuals, provides for comparison of the provided data with selected records.

Abstract: The invention provides a novel high throughput functional assay for certain agonist-activated receptors, including Alpha 1A, Alpha 2A, H1, 5HT1A, 5HT2A, D2 and D3 receptors. The assay method of the invention uses an elevated temperature and a cell line that stably expresses both the receptor and the promiscuous G protein G↑15 wherein agonist-induced intracellular Ca2+ release was monitored by a Fluorometric Imaging Plate Reader (FLIPR). The magnitude of the agonist-induced response was dramatically enhanced by performing the assay at an elevated temperature, rather than at room temperature. The novel assay of the invention is useful for selecting compounds which are effective in the treatment of disorders related to the activation of certain neuroreceptors.