Patents by Inventor Stevan B. Jovanovich
Stevan B. Jovanovich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130053255Abstract: The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.Type: ApplicationFiled: August 21, 2012Publication date: February 28, 2013Applicant: IntegenX, Inc.Inventors: Mattias Vangbo, William D. Nielsen, Iuliu I. Blaga, Joanne Horn, Michael Van Nguyen, Stevan B. Jovanovich
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Publication number: 20120315635Abstract: The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.Type: ApplicationFiled: August 20, 2012Publication date: December 13, 2012Applicant: IntegenX, Inc.Inventors: Mattias Vangbo, William D. Nielsen, luliu I. Blaga, Michael Van Nguyen, Stevan B. Jovanovich
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Publication number: 20110076735Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.Type: ApplicationFiled: June 15, 2010Publication date: March 31, 2011Inventors: Stevan B. Jovanovich, Iuliu I. Blaga
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Publication number: 20110005932Abstract: The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.Type: ApplicationFiled: June 7, 2010Publication date: January 13, 2011Applicant: IntegenX Inc.Inventors: Stevan B. JOVANOVICH, William D. Nielsen, David S. Cohen, Michael Recknor, Mattias Vangbo, Ezra Van Gelder, Lars Majlof, Omar El-Sissi
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Publication number: 20100303687Abstract: This invention provides fluidic devices, in particular microfluidic devices, with diaphragm valves having low failure rates. Low failure rates are achieved by inhibiting sticking of the diaphragm to functional surfaces such as valve seats, valve chamber and fluidic channels and conduits. One way to implement this is to provide exposed surfaces facing the diaphragm, particularly valve seats, with a low energy material, such as a noble metal, a perfluorinated polymer, a self-assembled monolayer, hard diamond, diamond-like carbon or a metal oxide. In other embodiments, the valves are provided with ridges and the diaphragm is adhered to the fluidic or actuation layer with an adhesive material.Type: ApplicationFiled: May 27, 2010Publication date: December 2, 2010Applicant: IntegenX Inc.Inventors: Iuliu I. BLAGA, Stevan B. Jovanovich, Boris Kobrin, Ezra Van Gelder
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Publication number: 20100165784Abstract: This invention provides microfluidic devices that comprise a fluidics layer having microfluidic channels and one or more regulating layers that regulate the movement of fluid in the channels. The microfluidic devices can be used to mix one or more fluids. At least a portion of the fluidics layer can be isolated from the regulating layer, for example in the form of a shelf. Such isolated portions can be used as areas in which the temperature of liquids is controlled. Also provided are instruments including thermal control devices into which the microfluidic device is engaged so that the thermal control device controls temperature in the isolated portion, and a movable magnetic assembly including magnets with shields so that a focused magnetic field can be applied to or withdrawn from the isolated portion or any other portion of the microfluidic device. Also provided are methods of mixing fluids.Type: ApplicationFiled: December 18, 2009Publication date: July 1, 2010Applicant: Microchip Biotechnologies, Inc., a California CorporationInventors: Stevan B. JOVANOVICH, William D. Nielsen, Michael Recknor, Mary Trounstine
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Patent number: 7745207Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.Type: GrantFiled: February 2, 2007Date of Patent: June 29, 2010Assignee: IntegenX, Inc.Inventors: Stevan B. Jovanovich, Iuliu I. Blaga
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Publication number: 20090253181Abstract: The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.Type: ApplicationFiled: January 21, 2009Publication date: October 8, 2009Applicant: Microchip Biotechnologies, Inc.Inventors: Mattias Vangbo, William D. Nielsen, Lullu I. Blaga, Seth Stern, Joanne Horn, Michael Van Nguyen, Stevan B. Jovanovich
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Patent number: 7244961Abstract: Modular fluidic microchips, systems integrating such microchips, and associated preparative and analytical methods are presented.Type: GrantFiled: February 2, 2005Date of Patent: July 17, 2007Assignee: Silicon Valley ScientificInventors: Stevan B. Jovanovich, Iuliu Blaga, Roger McIntosh
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Publication number: 20040262162Abstract: A substrate with a plurality of microchannels is movably deployed with other movable objects that will load sample into the microchannels, stimulate molecular migration, read the results of the migration, remove and replace the substrate, and prepare for a new run. The other objects include a gripper for engaging and moving the substrate, an electrode array of fine wires suitable for fitting into the microchannels for electromigration, and a scanning detector for reading migration results. A sequence of automatic operations is established so that one substrate after another may be moved into position, loaded with sample, stimulated for molecular migration, read with a beam, and then removed and replaced with a fresh substrate.Type: ApplicationFiled: July 15, 2004Publication date: December 30, 2004Inventors: David J. Roach, Robert T. Loder, Thomas M. Armstrong, Dennis W. Harris, Stevan B. Jovanovich, Richard F. Johnston
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Patent number: 6787111Abstract: An apparatus for filling and cleaning channels and inlet ports of a microchip substrate is disclosed. A device of the apparatus comprising an array of tubes is inserted into each of the inlet ports of the microchip. The array of tubes of the device comprises a plurality of pressure tubes, surrounded by a plurality of vacuum tubes. In conjunction with this, pressurized solutions such as matrix or wash are introduced into common openings on the microchip that provide a passage to microchannels of the microchip with the use of pressure tip injectors of the apparatus. As matrix or wash solutions are pumped through the common openings and microchannels of the microchip substrate, wash solutions are pumped through the plurality of pressure tubes and everything is vacuumed through the plurality of vacuum tubes surrounding the plurality of pressure tubes. Various reservoirs of solutions are selected and allowed to flow by proper valve actuation.Type: GrantFiled: December 13, 2000Date of Patent: September 7, 2004Assignee: Amersham Biosciences (SV) Corp.Inventors: David J. Roach, Robert T. Loder, Jr., Thomas M. Armstrong, Dennis W. Harris, Stevan B. Jovanovich, Richard F. Johnston
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Patent number: 6764648Abstract: A substrate with a plurality of microchannels is movably deployed with other movable objects that will load sample into the microchannels, stimulate molecular migration, read the results of the migration, remove and replace the substrate, and prepare for a new run. The other objects include a gripper for engaging and moving the substrate, an electrode array of fine wires suitable for fitting into the microchannels for electromigration, and a scanning detector for reading migration results. A sequence of automatic operations is established so that one substrate after another may be moved into position, loaded with sample, stimulated for molecular migration, read with a beam, and then removed and replaced with a fresh substrate.Type: GrantFiled: April 20, 2000Date of Patent: July 20, 2004Assignee: Amersham Biosciences (SV) Corp.Inventors: David J. Roach, Robert T. Loder, Jr., Thomas M. Armstrong, Dennis W. Harris, Stevan B. Jovanovich, Richard F. Johnston
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Patent number: 6627446Abstract: A substrate with a plurality of microchannels is movably deployed with other movable objects that will load sample into the microchannels, stimulate molecular migration, read the results of the migration, remove and replace the substrate, and prepare for a new run. The other objects include a gripper for engaging and moving the substrate, an electrode array of fine wires suitable for fitting into the microchannels for electromigration, and a scanning detector for reading migration results. A sequence of automatic operations is established so that one substrate after another may be moved into position, loaded with sample, stimulated for molecular migration, read with a beam, and then removed and replaced with a fresh substrate.Type: GrantFiled: July 2, 1998Date of Patent: September 30, 2003Assignee: Amersham Biosciences (SV) CorpInventors: David J. Roach, Robert T. Loder, Jr., Thomas M. Armstrong, Dennis W. Harris, Stevan B. Jovanovich, Richard F. Johnston
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Patent number: 6551839Abstract: A capillary valve, connector and router where one or more cylindrical fibers, which may be capillaries, plugged capillaries, optical fibers, or the like, including at least one capillary tube are contained in a first bundle of fibers that terminates at a first face. A second cylindrical bundle of fibers also containing one or more fibers including at least one capillary tube terminates in a second face abutting the first face. A fastener or adapter holds the members together with faces in mutually biased alignment. Connection of a plurality of macroscale pumps enables push-pull fluid motion, with routing, in a capillary system formed by a plurality of fibers coupled by switches, connectors and routers. Chemical reactions, separations and analysis may be carried out with microliter volumes or smaller.Type: GrantFiled: January 25, 2001Date of Patent: April 22, 2003Assignee: Amersham Biosciences Corp.Inventors: Stevan B. Jovanovich, Gregory J. Ronan, David J. Roach, Richard F. Johnston
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Publication number: 20020110900Abstract: A method and device for preparing nanoscale reactions. An automated system utilizes an array of reaction chambers. The ends of the chambers are temporarily sealed with deformable membranes and reactions effected by incubation of temperature cycling. Reaction mixtures may be assembled by using the reaction containers to meter reaction components. After the reaction is finished, the reaction containers may be dispensed onto a substrate and the reaction products analyzed. An automated transfer device may be used for automated transport of the reaction container array or other transportable elements.Type: ApplicationFiled: April 18, 2002Publication date: August 15, 2002Inventors: Stevan B. Jovanovich, David J. Roach
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Patent number: 6423536Abstract: A method and device for preparing nanoscale reactions. An automated system utilizes an array of reaction chambers. The ends of the chambers are temporarily sealed with deformable membranes and reactions effected by incubation or temperature cycling. Reaction mixtures may be assembled by using the reaction containers to meter reaction components. After the reaction is finished, the reaction containers may be dispensed onto a substrate and the reaction products analyzed. An automated transfer device may be used for automated transport of the reaction container array or other transportable elements.Type: GrantFiled: May 23, 2000Date of Patent: July 23, 2002Assignee: Molecular Dynamics, Inc.Inventors: Stevan B. Jovanovich, David J. Roach, Andrew G. Hadd, Bo E. R. Hellman
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Publication number: 20010007641Abstract: A capillary valve, connector and router where one or more cylindrical fibers, which may be capillaries, plugged capillaries, optical fibers, or the like, including at least one capillary tube are contained in a first cylindrical bundle of fibers that terminates at a first face. A second cylindrical bundle of fibers also containing one or more fibers including at least one capillary tube terminates in a second face abutting the first face. A fastener or adapter holds the members together with faces in mutually biased alignment, allowing relative rotation of the two cylindrical bundles which terminate in rotatable ferrules. Various functions achieved by rotation include a zero dead volume slide valve, a fluid router and a manifold. The fibers in each sleeve are preferably of uniform size for close symmetrical packing, but could be of disparate sizes, allowing connection of macroscale tubes to capillary tubes.Type: ApplicationFiled: January 25, 2001Publication date: July 12, 2001Inventors: Stevan B. Jovanovich, Gregory J. Ronan, David J. Roach
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Publication number: 20010005489Abstract: An apparatus for filling and cleaning channels and inlet ports of a microchip substrate is disclosed. A device of the apparatus comprising an array of tubes is inserted into each of the inlet ports of the microchip. The array of tubes of the device comprises a plurality of pressure tubes, surrounded by a plurality of vacuum tubes. In conjunction with this, pressurized solutions such as matrix or wash are introduced into common openings on the microchip that provide a passage to microchannels of the microchip with the use of pressure tip injectors of the apparatus. As matrix or wash solutions are pumped through the common openings and microchannels of the microchip substrate, wash solutions are pumped through the plurality of pressure tubes and everything is vacuumed through the plurality of vacuum tubes surrounding the plurality of pressure tubes. Various reservoirs of solutions are selected and allowed to flow by proper valve actuation.Type: ApplicationFiled: December 13, 2000Publication date: June 28, 2001Inventors: David J. Roach, Robert T. Loder, Thomas M. Armstrong, Dennis W. Harris, Stevan B. Jovanovich, Richard F. Johnston
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Patent number: 6190616Abstract: A capillary valve, connector and router where one or more cylindrical fibers, which may be capillaries, plugged capillaries, optical fibers, or the like, including at least one capillary tube are contained in a first cylindrical bundle of fibers that terminates at a first face. A second cylindrical bundle of fibers also containing one or more fibers including at least one capillary tube terminates in a second face abutting the first face. A fastener or adapter holds the members together with faces in mutually biased alignment, allowing relative rotation of the two cylindrical bundles which terminate in rotatable ferrules. Various functions achieved by rotation include a zero dead volume slide valve, a fluid router and a manifold. The fibers in each sleeve are preferably of uniform size for close symmetrical packing, but could be of disparate sizes, allowing connection of macroscale tubes to capillary tubes.Type: GrantFiled: September 11, 1997Date of Patent: February 20, 2001Assignee: Molecular Dynamics, Inc.Inventors: Stevan B. Jovanovich, Gregory J. Ronan, David J. Roach, Richard F. Johnston
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Patent number: 5756304Abstract: The present invention is directed to the application of robotics to screen and optimize microorganisms for their bioremediation capabilities. In particular, the present invention provides methods to screen for the ability of microorganisms to metabolize particular compounds of interest in bioremediation applications. The present invention also provides a method for discovery of microorganisms useful for bioremediation and biomining, as well as other applications where microbial metabolism is useful for catalyzing chemical biotransformations.Type: GrantFiled: July 14, 1995Date of Patent: May 26, 1998Assignee: Molecular SolutionsInventor: Stevan B. Jovanovich