Abstract: The present invention pertains to an orthopedic support having a flexible inner member and an exo-skeleton that is molded directly onto the flexible inner member. One aspect of the invention relates to a wrist support having a thumb spica. The wrist support includes a molded plastic exostructure supplying support for resisting motion of said wrist. An inner fabric support is attached to said molded exostructure for providing cushioning to the wrist area. A separate, attachable thumb spica member is provided for optionally configuring the wrist support to include a thumb spica.