Abstract: A PSMA-specific agent comprising a compound according to Formula I or Formula II: wherein S1 is absent or is an organic spacer group comprising 3-10 carbons; A is an amino acid chain comprising 1 to 5 amino acids wherein at least one of the amino acids is selected from glutamic acid and aspartic acid; S2 is absent or is an organic spacer group comprising 1 to 15 carbons and/or 0 to 2 amino acids; I1 is an imaging group; and I2 is absent or is an imaging group. The PSMA-specific agents can be used to image PSMA within a tissue region and/or for the treatment of a cancer, such as prostate cancer.

Abstract: Microfluidic devices, systems and methods are described herein. The devices, systems and methods provide for trapping particles, including cells. Methods of generating a droplet in a microfluidic device and collecting droplets from microfluidic devices are also disclosed herein.

Abstract: Systems, devices and methods for integrating world-to-chip interfaces with digital microfluidics for bacterial transformation and enzymatic assays are described herein. The devices include a microfluidic device having a first plate comprising a cell culture region for maintaining a cell culture and a reservoir for storing reagents to induce at least a portion of the cell culture or to mix with other reagents and a second plate spaced apart from the first plate, the second plate defining one or more openings extending through the second plate. The device may include a reagent well coupled to the second plate. The reagent well may be configured to refill the reservoir on the first plate with liquid reagent via the one or more openings of the second plate. The device may also include a thermoelectric module (TEM) coupled to the first plate or the second plate for managing temperature control of the device.

Abstract: Provided are liners for a shaped charge and corresponding methods of use. An example liner comprises a generally conical shape having an apex, an open side, a liner wall comprising a thickness, and an axis extending through the center of the liner from the apex to the center of the open side. The liner comprises a liner height extending in a vertical plane from the center of the open side to the apex, a liner radius extending along a horizontal plane that is perpendicular to the axis at the open side of the liner and that extends from the axis to an outermost edge of the liner wall. The ratio of the liner height to the liner diameter is about 0.90 to about 1.10. The liner wall comprises an apex curvature, a first wall curvature, a second wall curvature, and a third wall curvature.

Abstract: A PSMA-specific imaging agent comprising a compound according to formula I: are described, wherein S1 is an organic spacer group having from 5 to 30 carbons, A is an amino acid forming a portion of a negatively charged peptide oligomer, n is from 3 to 6, S2 is an organic spacer group having from 5 to 15 carbons, and I is an imaging group, and pharmaceutically acceptable salts thereof. The PSMA-specific imaging agents can be used to image PSMA within a tissue region to guide the treatment of diseases such as prostate cancer.

Abstract: Provided are liners for a shaped charge and corresponding methods of use. An example liner comprises a generally conical shape having an apex, an open side, a liner wall comprising a thickness, and an axis extending through the center of the liner from the apex to the center of the open side. The liner comprises a liner height extending in a vertical plane from the center of the open side to the apex, a liner radius extending along a horizontal plane that is perpendicular to the axis at the open side of the liner and that extends from the axis to an outermost edge of the liner wall. The ratio of the liner height to the liner diameter is about 0.90 to about 1.10. The liner wall comprises an apex curvature, a first wall curvature, a second wall curvature, and a third wall curvature.

Abstract: There are provided various microfluidics devices. Microfluidics devices that include a culture area for mixing a composition and an assay area for measuring enzyme activity of samples of the bacterial culture are, for example, provided. The assay area may include an optical density reader. The optical density reader may include a light emitting source and sensor to allow monitoring of the optical density of samples. Microfluidic devices comprising a first plate comprising at least one hydrophilic site are also provided as well as methods of manufacture thereof. Methods for performing analyses of compositions on microfluidics devices comprising a plate assembly having a first plate and a second plate are also provided in various embodiments.

Abstract: A PSMA-specific imaging agent comprising a compound according to formula I: are described, wherein S1 is an organic spacer group having from 5 to 30 carbons, A is an amino acid forming a portion of a negatively charged peptide oligomer, n is from 3 to 6, S2 is an organic spacer group having from 5 to 15 carbons, and I is an imaging group, and pharmaceutically acceptable salts thereof. The PSMA-specific imaging agents can be used to image PSMA within a tissue region to guide the treatment of diseases such as prostate cancer.

Abstract: A PSMA-specific imaging agent comprising a compound according to formula I: are described, wherein S1 is an organic spacer group having from 5 to 30 carbons, A is an amino acid forming a portion of a negatively charged peptide oligomer, n is from 3 to 6, S2 is an organic spacer group having from 5 to 15 carbons, and I is an imaging group, and pharmaceutically acceptable salts thereof. The PSMA-specific imaging agents can be used to image PSMA within a tissue region to guide the treatment of diseases such as prostate cancer.

Abstract: A PSMA-specific imaging agent comprising a compound according to formula I: are described, wherein S1 is an organic spacer group having from 5 to 30 carbons, A is an amino acid forming a portion of a negatively charged peptide oligomer, n is from 3 to 6, S2 is an organic spacer group having from 5 to 15 carbons, and I is an imaging group, and pharmaceutically acceptable salts thereof. The PSMA-specific imaging agents can be used to image PSMA within a tissue region to guide the treatment of diseases such as prostate cancer.

Abstract: The latencies associated with retrieving instruction information for a main thread are decreased through the use of a simultaneous helper thread. The helper thread is a speculative prefetch thread to perform instruction prefetch and/or trace pre-build for the main thread.

Abstract: The latencies associated with cache misses or other long-latency instructions in a main thread are decreased through the use of a simultaneous helper thread. The helper thread is a speculative prefetch thread to perform a memory prefetch for the main thread. The instructions for the helper thread are dynamically incorporated into the main thread binary during post-pass operation of a compiler.

Abstract: The latencies associated with cache misses or other long-latency instructions in a main thread are decreased through the use of a simultaneous helper thread. The helper thread is a speculative prefetch thread to perform a memory prefetch for the main thread. The instructions for the helper thread are dynamically incorporated into the main thread binary during post-pass operation of a compiler.

Abstract: Apparatus, system and methods are provided for performing speculative data prefetching in a chip multiprocessor (CMP). Data is prefetched by a helper thread that runs on one core of the CMP while a main program runs concurrently on another core of the CMP. Data prefetched by the helper thread is provided to the helper core. For one embodiment, the data prefetched by the helper thread is pushed to the main core. It may or may not be provided to the helper core as well. A push of prefetched data to the main core may occur during a broadcast of the data to all cores of an affinity group. For at least one other embodiment, the data prefetched by a helper thread is provided, upon request from the main core, to the main core from the helper core's local cache.

Abstract: A layered structure comprising in this order: (A) a silicon carbide layer, (B) at least one stratum (b1) located at least one major surface of the silicon carbide layer (A), (b2) chemically bonded to the bulk of the silicon carbide layer (A) by silicon-oxygen and/or silicon-carbon bonds, (b3) covering the at least one major surface of the silicon carbide layer (A) partially or completely, and (b4) having a higher polarity than a pure silicon carbide surface as exemplified by a contact angle with water which is lower than the contact angle of water with a pure silicon carbide surface; and (C) at least one dielectric layer, which covers the stratum or the strata (B) partially or completely and is selected from inorganic and inorganic-organic hybrid dielectric layers; a process for its manufacture and its use.

Abstract: The present invention concerns a method of making a porous material comprising the following steps in the order a-b-c-d: (a) reacting at least one organosilane (A) with water in the presence of a solvent (C) to form a polymeric material, (b) subjecting said polymeric material to a first heat treatment, (c) bringing said polymeric material into contact with at least one dehydroxylation agent (D), (d) subjecting said polymeric material to electromagnetic radiation and/or to a further heat treatment. The present invention furthermore concerns the porous material obtainable by the inventive method, semiconductor devices and electronic components comprising said porous material, and the use of said material for electrical insulation and in microelectronic devices, membranes, displays and sensors.

Abstract: In one embodiment a thread management method identifies in a main program a set of instructions that can be dynamically activated as speculative precomputation threads. A wait/sleep operation is performed on the speculative precomputation threads between thread creation and activation, and progress of non-speculative threads is gauged through monitoring a set of global variables, allowing the speculative precomputation threads to determine its relative progress with respect to non-speculative threads.

Abstract: Apparatus, system and methods are provided for performing speculative data prefetching in a chip multiprocessor (CMP). Data is prefetched by a helper thread that runs on one core of the CMP while a main program runs concurrently on another core of the CMP. Data prefetched by the helper thread is provided to the helper core. For one embodiment, the data prefetched by the helper thread is pushed to the main core. It may or may not be provided to the helper core as well. A push of prefetched data to the main core may occur during a broadcast of the data to all cores of an affinity group. For at least one other embodiment, the data prefetched by a helper thread is provided, upon request from the main core, to the main core from the helper core's local cache.

Abstract: The latencies associated with retrieving instruction information for a main thread are decreased through the use of a simultaneous helper thread. The helper thread is a speculative prefetch thread to perform instruction prefetch and/or trace pre-build for the main thread.

Abstract: Apparatus, system and methods are provided for performing speculative data prefetching in a chip multiprocessor (CMP). Data is prefetched by a helper thread that runs on one core of the CMP while a main program runs concurrently on another core of the CMP. Data prefetched by the helper thread is provided to the helper core. For one embodiment, the data prefetched by the helper thread is pushed to the main core. It may or may not be provided to the helper core as well. A push of prefetched data to the main core may occur during a broadcast of the data to all cores of an affinity group. For at least one other embodiment, the data prefetched by a helper thread is provided, upon request from the main core, to the main core from the helper core's local cache.