Patents by Inventor Steven Andrew McCarroll

Steven Andrew McCarroll has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Droplet-based method and apparatus for composite single-cell nucleic acid analysis
    Patent number: 11597964
    Abstract: The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: March 7, 2023
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Aviv Regev, Evan Zane Macosko, Steven Andrew McCarroll, Alexander K. Shalek, Anindita Basu, Christopher B. Ford, Hongkun Park, David A. Weitz
  • Droplet-based method and apparatus for composite single-cell nucleic acid analysis
    Patent number: 11566279
    Abstract: The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: January 31, 2023
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Aviv Regev, Evan Zane Macosko, Steven Andrew McCarroll, Alexander K. Shalek, Anindita Basu, Christopher B. Ford, Hongkun Park, David A. Weitz
  • Clonal haematopoiesis
    Patent number: 10683552
    Abstract: The present invention relates to clonal expansion of somatic cells in subjects, and acquired selective advantage of cell clones during the lifetime of a subject. In particular, the invention relates to methods for predicting the development of cancer based on the observation of specific genetic mutations in somatic cell clones, as well as to methods for treating or preventing cancer in a subject, in which clonal expansion of cells comprising specific modifications is observed.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: June 16, 2020
    Assignees: Presidents and Fellows of Harvard College, The Broad Institute, Inc.
    Inventors: Steven Andrew McCarroll, Giulio Genovese
  • Droplet-Based Method And Apparatus For Composite Single-Cell Nucleic Acid Analysis
    Publication number: 20190127782
    Abstract: The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.
    Type: Application
    Filed: January 9, 2019
    Publication date: May 2, 2019
    Inventors: Aviv REGEV, Evan Zane MACOSKO, Steven Andrew MCCARROLL, Alexander K. SHALEK, Anindita BASU, Christopher B. FORD, Hongkun PARK, David A. WEITZ
  • Droplet-Based Method And Apparatus For Composite Single-Cell Nucleic Acid Analysis
    Publication number: 20180030515
    Abstract: The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.
    Type: Application
    Filed: March 8, 2017
    Publication date: February 1, 2018
    Inventors: Aviv Regev, Evan Zane MACOSKO, Steven Andrew MCCARROLL, Alexander K. SHALEK, Anindita BASU, Christopher B. FORD, Hongkun PARK, David A. WEITZ
  • CLONAL HAEMATOPOIESIS
    Publication number: 20170321284
    Abstract: The present invention relates to clonal expansion of somatic cells in subjects, and acquired selective advantage of cell clones during the lifetime of a subject. In particular, the invention relates to methods for predicting the development of cancer based on the observation of specific genetic mutations in somatic cell clones, as well as to methods for treating or preventing cancer in a subject, in which clonal expansion of cells comprising specific modifications is observed.
    Type: Application
    Filed: November 23, 2015
    Publication date: November 9, 2017
    Applicants: The Broad Institute Inc., President and Fellows of Harvard College
    Inventors: Steven Andrew McCarroll, Giulio Genovese