Patents by Inventor Steven C. Hebert

Steven C. Hebert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING HYPERACIDIC DISORDERS
    Publication number: 20120232158
    Abstract: The present invention relates to methods for treating or preventing hyperacidic disorders such as GERD or NERD using calcium receptor active compounds.
    Type: Application
    Filed: March 3, 2009
    Publication date: September 13, 2012
    Inventors: John Peter Geibel, Steven C. Hebert, Patricia R. Hebert, David Martin
  • Polycation-sensing receptor in aquatic species and methods of use thereof
    Patent number: 7038014
    Abstract: Polycation-sensing receptors present in aquatic species and methods of regulating polycation-sensing receptor-mediated functions in aquatic species are described.
    Type: Grant
    Filed: December 10, 2001
    Date of Patent: May 2, 2006
    Assignee: Brigham and Women's Hospital
    Inventors: H. William Harris, Edward M. Brown, Steven C. Hebert
  • Polycation-sensing receptor in aquatic species and methods of use thereof
    Publication number: 20030166908
    Abstract: Polycation-sensing receptors present in aquatic species and methods of regulating polycation-sensing receptor-mediated functions in aquatic species are described.
    Type: Application
    Filed: December 10, 2001
    Publication date: September 4, 2003
    Applicant: Brigham and Women's Hospital
    Inventors: H. William Harris, Edward M. Brown, Steven C. Hebert
  • Polycation-sensing receptor in aquatic species and methods of use
    Patent number: 6337391
    Abstract: Polycation-sensing receptors present in aquatic species and methods of regulating polycation-sensing receptor-mediated functions in aquatic species are described.
    Type: Grant
    Filed: September 28, 1998
    Date of Patent: January 8, 2002
    Assignee: Brighams & Women's Hospital
    Inventors: H. William Harris, Edward M. Brown, Steven C. Hebert
  • Calcium receptor-active molecules
    Patent number: 5962314
    Abstract: The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
    Type: Grant
    Filed: October 3, 1997
    Date of Patent: October 5, 1999
    Assignees: NPS Pharmaceuticals, Inc., Brigham and Women's Hospital
    Inventors: Edward M. Brown, Steven C. Hebert, James E. Garrett, Jr.
  • Method of screening calcium receptor-active molecules
    Patent number: 5858684
    Abstract: The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 12, 1999
    Assignees: The Brigham and Women's Hospital, Inc., NPS Pharmaceuticals, Inc.
    Inventors: Edward F. Nemeth, Edward M. Brown, Steven C. Hebert, James E. Garrett, Jr., Bradford C. Van Wagenen, Manuel F. Balandrin, Eric G. Del Mar
  • Calcium receptor-active molecules
    Patent number: 5763569
    Abstract: The present invention features calcium receptor polypeptides and fragments thereof. Uses of a calcium receptor polypeptide include providing a polypeptide having the activity of a calcium receptor polypeptide. Calcium receptor polypeptide fragments can be used, for example, to generate antibodies to a calcium receptor polypeptide.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 9, 1998
    Assignees: The Brigham and Women's Hospital, Inc, NPS Pharmaceuticals, Inc.
    Inventors: Edward M. Brown, Steven C. Hebert, James E. Garrett, Jr.
  • Calcium receptor-active molecules
    Patent number: 5688938
    Abstract: The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 18, 1997
    Assignees: The Brigham & Women's Hospital, Inc., NPS Pharmaceuticals, Inc.
    Inventors: Edward M. Brown, Forrest H. Fuller, Steven C. Hebert, James E. Garrett, Jr.
  • Primary structure for functional expression from complementary DNA of a mammalian ATP-sensitive potassium channel
    Patent number: 5356775
    Abstract: This invention is directed to the cloning of the gene which encodes an ATP-sensitive K.sup.+ channel in rat outer medulla cells, isolated cDNA sequences which encode said ATP-sensitive K.sup.+ channels, isolated proteins produced by said cDNA sequences, and agents capable of binding to said proteins. Further included in the invention are methods for identifying other members of the family of ATP-sensitive potassium channels (the ROMK1 family of channel proteins), identifying, isolating, and cloning the genes which encode ROMK1 associated polypeptides, identifying agents capable of binding to other members of the family, modulating expression of said family of ATP-sensitive potassium channels, and modulating the activity of said family of ATP-sensitive potassium channels. Additionally, included in the invention are methods for identifying drugs which function as K.sub.ATP channel openers and K.sub.ATP channel closers.
    Type: Grant
    Filed: July 29, 1992
    Date of Patent: October 18, 1994
    Assignee: Brigham & Women's Hospital
    Inventors: Steven C. Hebert, Kevin Ho