Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: A web-connecting assembly may include a connecting member and a securing member. The connecting member may include a connecting stud and a first web channel. The first web channel is configured to retain a first web. The securing member may include a housing defining a retaining chamber, a button pivotally secured to the housing, and a second web channel. The second web channel is configured to retain a second web. The button is configured to be moved between an open position in which a portion of the connecting stud is able to move into and out of the retaining chamber, and a closed position in which the button securely traps the portion of the connecting stud within the retaining chamber. The connecting member is securely connected to the securing member when the button securely traps the portion of the connecting stud within the retaining chamber.

Abstract: A web-connecting assembly may include a connecting member and a securing member. The connecting member may include a connecting stud and a first web channel. The first web channel is configured to retain a first web. The securing member may include a housing defining a retaining chamber, a button pivotally secured to the housing, and a second web channel. The second web channel is configured to retain a second web. The button is configured to be moved between an open position in which a portion of the connecting stud is able to move into and out of the retaining chamber, and a closed position in which the button securely traps the portion of the connecting stud within the retaining chamber. The connecting member is securely connected to the securing member when the button securely traps the portion of the connecting stud within the retaining chamber.

Abstract: A buckle having linear engagement and disengagement activation. The buckle includes a body having a hollow sleeve portion defining a through passage extending between a proximal opening and a distal opening. Lateral openings are disposed along opposing sides of the sleeve portion. A depressible button is held in reciprocating relation within the distal opening. A male latch member having a pair of legs is adapted to be inserted into the proximal opening for locking engagement of the legs behind tabs within the sleeve portion. The latch member is releasable upon depression of the button.

Abstract: A web-connecting assembly may include a connecting member and a securing member. The connecting member may include a connecting stud and a first web channel. The first web channel is configured to retain a first web. The securing member may include a housing defining a retaining chamber, a button pivotally secured to the housing, and a second web channel. The second web channel is configured to retain a second web. The button is configured to be moved between an open position in which a portion of the connecting stud is able to move into and out of the retaining chamber, and a closed position in which the button securely traps the portion of the connecting stud within the retaining chamber. The connecting member is securely connected to the securing member when the button securely traps the portion of the connecting stud within the retaining chamber.

Abstract: A buckle having linear engagement and disengagement activation. The buckle includes a body having a hollow sleeve portion defining a through passage extending between a proximal opening and a distal opening. Lateral openings are disposed along opposing sides of the sleeve portion. A depressible button is held in reciprocating relation within the distal opening. A male latch member having a pair of legs is adapted to be inserted into the proximal opening for locking engagement of the legs behind tabs within the sleeve portion. The latch member is releasable upon depression of the button.

Abstract: A lashing system having one or more cord anchors fastenable to a stationary member in spaced apart relation, and one or more cord clips each having a first portion with a first cord engaging member releasably and coupleable to a first cord portion and a second portion with a second cord engaging member selectively and releasably coupleable to a second cord portion so as to accommodate a particular article stowage application. The cord anchors also have a cord engaging member releasably coupleable to the cord, whereby the cord may be selectively coupled to one or more cord anchors, and thus positioned selectively on the stationary member. The lashing system also preferably includes a cord hook coupled to a first cord portion and a hook portion engagable by hooking to another cord portion.

Abstract: A buckle including a first buckle portion having an engagement member and a second buckle portion having socket arms forming a socket for releasably engaging the engagement member. A sleeve member is reciprocatably disposed about the socket arms between first, second and third positions, whereby the sleeve member in the first position prevents expansion of the socket arms so as to retain the engagement member, and the socket arms are expandable when the sleeve member is in the second and third positions so as to permit release of the engagement member from the socket and insertion of the engagement member into the socket.

Abstract: A buckle including a male member having a tongue with one or more tongue protrusions each having a tongue engagement portion extending from one or more side portions thereof, and a female member having a recess with one or more recess protrusions each having a recess engagement portion extending from one or more inner side portions thereof. A resilient spring member protruding from one of the tongue or the recess of the female member is engageable with the other of the recess or the tongue to laterally shift the tongue in the recess when the tongue engagement portions are inserted into the recess beyond the recess engagement portions, whereby the tongue engagement portions are engageable with the recess engagement portions to retain the tongue in the recess after the tongue is laterally shifted by the resilient spring member.

Abstract: A buckle including a female receptacle member having a tubular body, an interior channel therethrough and being open to the channel on a portion of the tubular body, a male latch member having at least one arm member for insertion within the channel through the open end of the female receptacle member and a latch member formed between the tubular body and the arm member for releasable locking engagement of the tubular body and the arm member upon insertion of the arm member within the channel and for providing a resistance force in opposition to and alignment with an arm member removal loading force between the tubular body and the arm member.

Abstract: A buckle having a sleeve portion including a receiving channel, a web connector member positioned within the channel for cooperation with the sleeve, and a spring member integrally formed with the web connector member for providing a spring bias to the web connector member with respect to the sleeve so that a web can be affixed to the buckle for adjustable cooperation with the web connector member, the sleeve and the spring member with the web connector member being accessible from the exterior of the buckle for manipulation by a user against the force of the spring member so as to adjust or remove the web.

Abstract: A chin strap buckle for securing a protective helmet to a wearer's head includes a female snap fastener member and a male snap fastener member which snappingly interlock together at their respective one ends in a pivotal relationship. The female member is formed of a substantially triangularly-shaped mid-portion and left and right end portions formed integrally with the opposite sides of the mid-portion. The mid-portion has a trough-like recess formed at its top. The male snap fastener member is formed of a triangular body portion and a lower end portion. The body portion has a post extending outwardly therefrom adjacent its top. The post has an enlarged button and a neck connecting the button to the body portion. The neck of the body portion of the male member is snappingly received within the trough-like recess formed at the top of the female member for interlocking the male and female members together.