Patents by Inventor Steven D. Kunkel

Steven D. Kunkel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220280535
    Abstract: The invention provides a method for (a) increasing skeletal muscle mass; (b) reducing skeletal muscle atrophy; (c) increasing muscular strength; (d) promoting muscle growth; (e) decreasing muscle wasting; or (f) increasing strength per unit of muscle mass in an animal identified or having been identified to be in need of one or more of (a)-(f), the method comprising administering to the animal an effective amount of a compound of formula: or a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, thereby accomplishing one or more of (a)-(f).
    Type: Application
    Filed: May 17, 2021
    Publication date: September 8, 2022
    Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Christopher M. ADAMS, Steven D. KUNKEL, Michael WELSH
  • Patent number: 11090313
    Abstract: The invention provides a method for (a) increasing skeletal muscle mass; (b) reducing skeletal muscle atrophy; (c) increasing muscular strength; (d) promoting muscle growth; (e) decreasing muscle wasting; or (f) increasing strength per unit of muscle mass in an animal identified or having been identified to be in need of one or more of (a)-(f), the method comprising administering to the animal an effective amount of a compound of formula: or a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, thereby accomplishing one or more of (a)-(f).
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: August 17, 2021
    Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Christopher M. Adams, Steven D. Kunkel, Michael Welsh
  • Patent number: 10668087
    Abstract: In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: June 2, 2020
    Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Christopher M. Adams, Steven D. Kunkel, Michael Welsh
  • Publication number: 20200061083
    Abstract: The invention provides a method for (a) increasing skeletal muscle mass; (b) reducing skeletal muscle atrophy; (c) increasing muscular strength; (d) promoting muscle growth; (e) decreasing muscle wasting; or (f) increasing strength per unit of muscle mass in an animal identified or having been identified to be in need of one or more of (a)-(f), the method comprising administering to the animal an effective amount of a compound of formula: or a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, thereby accomplishing one or more of (a)-(f).
    Type: Application
    Filed: October 23, 2019
    Publication date: February 27, 2020
    Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Christopher M. ADAMS, Steven D. KUNKEL, Michael WELSH
  • Publication number: 20190105333
    Abstract: In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: October 11, 2018
    Publication date: April 11, 2019
    Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Christopher M. ADAMS, Steven D. KUNKEL, Michael WELSH
  • Patent number: 10137136
    Abstract: In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: November 27, 2018
    Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Christopher M. Adams, Steven D. Kunkel, Michael Welsh
  • Publication number: 20180118657
    Abstract: In one aspect, the invention relates methods for inhibiting or preventing muscle atrophy or increasing muscle mass by providing to a subject in need thereof an effective amount of ursolic acid, a derivative thereof, or an analog of the ursane scaffold. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: November 6, 2017
    Publication date: May 3, 2018
    Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Christopher M. ADAMS, Steven D. KUNKEL, Manish SUNEJA, Michael WELSH
  • Patent number: 9856204
    Abstract: In one aspect, the invention relates methods for inhibiting or preventing muscle atrophy or increasing muscle mass by providing to a subject in need thereof an effective amount of ursolic acid, a derivative thereof, or an analog of the ursane scaffold. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: January 2, 2018
    Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES OF AMERICA AS REPRESENTED BY VETERANS AFFAIRS
    Inventors: Christopher M. Adams, Steven D. Kunkel, Manish Suneja, Michael Welsh
  • Publication number: 20160243132
    Abstract: In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: February 23, 2016
    Publication date: August 25, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Christopher M. ADAMS, Steven D. KUNKEL, Michael WELSH
  • Patent number: 9295664
    Abstract: In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: March 29, 2016
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Christopher M. Adams, Steven D. Kunkel, Michael Welsh
  • Publication number: 20140371188
    Abstract: In an aspect, the invention relates to compositions, methods, and kits for inhibiting or preventing skeletal muscle atrophy or inducing muscle hypertrophy by providing to an animal an effective amount of a composition comprising a Gadd45a and/or Cdkn1a inhibitor and an androgen and/or growth hormone elevator or an androgen and/or growth hormone receptor activator. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: November 21, 2012
    Publication date: December 18, 2014
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Christopher M. Adams, Steven D. Kunkel, Michael Welsh, Scott Ebert
  • Publication number: 20140228333
    Abstract: In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: June 6, 2012
    Publication date: August 14, 2014
    Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Christopher M. Adams, Steven D. Kunkel, Michael Welsh
  • Publication number: 20130203712
    Abstract: In one aspect, the invention relates methods for inhibiting or preventing muscle atrophy or increasing muscle mass by providing to a subject in need thereof an effective amount of ursolic acid, a derivative thereof, or an analog of the ursane scaffold. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: May 19, 2011
    Publication date: August 8, 2013
    Applicant: University of Iowa Research Foundation
    Inventors: Christopher M. Adams, Steven D. Kunkel