Abstract: The present invention relates to methods of treating a condition involving excessive adipogenesis. This method relates to selecting a subject having a condition involving excessive adipogenesis and administering to the selected subject a composition comprising a Thy1 protein or polypeptide fragment thereof, or an agent that enhances Thy1 expression, under conditions effective to treat the condition. The present invention also relates to isolated nucleic acid molecules encoding a Thy1 protein or the fragment thereof and pharmaceutical formulations including such a protein or fragment thereof or an agent that enhances Thy1 expression and a pharmaceutically acceptable carrier. The present invention also relates to methods of inhibiting adipogenesis and/or decreasing adipocyte size, as well as methods of screening a candidate compound for its ability to influence adipogenesis.

Abstract: The present invention relates to methods of treating a condition involving excessive adipogenesis. This method relates to selecting a subject having a condition involving excessive adipogenesis and administering to the selected subject a composition comprising a Thy1 protein or polypeptide fragment thereof, or an agent that enhances Thy1 expression, under conditions effective to treat the condition. The present invention also relates to isolated nucleic acid molecules encoding a Thy1 protein or the fragment thereof and pharmaceutical formulations including such a protein or fragment thereof or an agent that enhances Thy1 expression and a pharmaceutically acceptable carrier. The present invention also relates to methods of inhibiting adipogenesis and/or decreasing adipocyte size, as well as methods of screening a candidate compound for its ability to influence adipogenesis.

Abstract: For calculating the intraocular pressure (IOP) of an eye, an applanation tonometer comprises an applanator formed of an optics array, a force transducer, an image sensor, and a processing circuit configured to calculate an intraocular pressure of the eye using one or more pairs of measured force and applanated area. The tonometer is provided with a disposable tip that covers the applanator, thereby providing a replaceable, sterile and transmissive interface between the tonometer's applanator and a patient's eye. Preferably, the applanating surface has a matte finish. The tonometer calculates the intraocular pressure using a predetermined relationship between interocular pressure and the slope of the line defined by data relating to the forces required to applanate the eye and the geometry of applanated portions of the eye. In a preferred embodiment, the data acquisition is synchronous.

Abstract: For calculating the intraocular pressure (IOP) of an eye, an applanation tonometer comprises an applanator formed of an optics array, a force transducer, an image sensor, and a processing circuit configured to calculate an intraocular pressure of the eye using one or more pairs of measured force and applanated area. The tonometer is provided with a disposable tip that covers the applanator, thereby providing a replaceable, sterile and transmissive interface between the tonometer's applanator and a patient's eye. Preferably, the applanating surface has a matte finish. The tonometer calculates the intraocular pressure using a predetermined relationship between interocular pressure and the slope of the line defined by data relating to the forces required to applanate the eye and the geometry of applanated portions of the eye. In a preferred embodiment, the data acquisition is synchronous.

Abstract: For calculating the intraocular pressure (IOP) of an eye, an applanation tonometer comprises an applanator formed of an optics array, a force transducer, an image sensor, and a processing circuit configured to calculate an intraocular pressure of the eye using one or more pairs of measured force and applanated area. The tonometer is provided with a disposable tip that covers the applanator, thereby providing a replaceable, sterile and transmissive interface between the tonometer's applanator and a patient's eye. Preferably, the applanating surface has a matte finish. The tonometer calculates the intraocular pressure using a predetermined relationship between interocular pressure and the slope of the line defined by data relating to the forces required to applanate the eye and the geometry of applanated portions of the eye. In a preferred embodiment, the data acquisition is synchronous.

Abstract: System and methods for generating written reports based on succinct input from a user. A method of the present invention comprises entering a first mode for initialization; defining menus; entering a second mode for receiving information; entering information using the defined menus; interpreting the entered information; and generating a written report in response to the interpreting step. A system (100) of the present invention comprises a portable computer system having a memory (102), a processor (101), a detachable keyboard (107), a screen (104), and a pen (105). Ancillary information is entered with the keyboard which is then detached. Subsequent information is documented by selecting appropriate items from the defined menus; alternatively, the information can be written on the screen with the pen. The processor is programmed to interpret the inputs and generate a report. The report may be printed on a printer (108), stored on a storage device, and/or transferred to another system.

Abstract: Disclosed is a completely portable, hand-held digital ultrasonic instrument about the size and shape of an ordinary pen. The housing is contoured such that it can be easily grasped in the manner of a writing pen. An activation button is located on the interior dorsal surface in close approximation to the index fingertip of the user. A liquid crystal display provides a digital readout of a thickness measurement on the barrel of the instrument housing. The instrument incorporates a 10 MHz or 20 MHz solid phase piezoelectric transducer, a microprocessor, a gate array, a hybrid analog circuit, a liquid crystal display, batteries and a removable battery cover. The 20 MHz transducer is used to measure corneal thickness and is attached to a swan neck connector which is attached to the instrument housing. The 10 MHz transducer is used for measuring axial length and it is attached to a truncated conical connector which is also attached to the instrument housing.

Abstract: Disclosed is a digital ultrasonic instrument for measuring the corneal thickness (often referred to as a pachymeter) and for measuring the axial length of the eye (often referred to as a biometric ruler). A number representing corneal thickness or axial length is displayed digitally on a liquid crystal display. The pachymeter incorporates a 20 MHz solid phase piezoelectric transducer, a microprocessor, a gate array, a hybrid analog receiver circuit, a liquid crystal display and four batteries. When axial length is measured, the instrument operates as a biometric ruler, a 10 MHz transducer is used and the software in the microprocessor is modified. Ultrasonic echoes generated by the transducer and various interfaces in the eye are sampled at the rate of 40 MHz which results in equal or greater sensitivity, resolution and accuracy as compared to other pachymeters and biometric rulers currently available.

Abstract: Disclosed is a battery powered, hand-held self-contained electronic tonometer with a digital readout for displaying pressure in millimeters of mercury. The tonometer includes a transducer which is a solid state pressure sensitive element and which produces a voltage proportional to intraocular pressure. An electrical waveform is produced by gently bringing the transducer in contact with the cornea. The waveform is converted to a digital signal and processed by a single chip microprocessor. The baseline of a reference signal is nulled by equalizing the charges on two capacitors on the inputs of two differential amplifiers. Equalizing the differential inputs of the two amplifier stages results in a gain of zero and removes any carrier signal. Microprocessor software detects the baseline condition established by equalizing the differential inputs. The microprocessor then looks for a series of valid measurements and calculates the average intraocular pressure along with an estimate of reliability.

Abstract: An improved keratometer instrument capable of measuring keratometric values of an eye is provided. An optical reference of a predetermined dimensional value is directed at the cornea of the eye and an optical sensor measures the same at different meridians. A computer circuit can determine whether the instrument is de-centered or de-focused relative to the eye and can derive measurements of keratometric values. The axis of astigmatism can be visually displayed to the surgeon during an operation.