Abstract: Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

Abstract: A preform and container design for a pressurized refillable plastic container, such as a PET carbonated beverage container, having a base section with increased resistance to sprue cracking. Sprue cracking, which may be a problem in warmer climates, is believed to be caused in prior designs by an entrapment of material between the stretch rod tip and the blow mold base during blow molding of the container, which entrapment causes surface defects in the container adjacent the sprue. These surface defects expand during flexing of the container dome, caused by alternating cycles of thermal shrinkage and expansion during container cleaning and filling. Sprue cracking can be reduced by eliminating a depressed dish adjacent the sprue in prior known refillable containers, and may further be reduced by modifications to the preform and container wall thickness ratios and base clearance height.