Abstract: The invention relates to a method of treating cancer, involving the combination of an ICOS binding protein, a PD-1 inhibitor and a TGF-? inhibitor. In particular, the invention relates to an ICOS binding protein (e.g. an anti-ICOS antibody) and a fusion protein targeting human protein Programmed Death Ligand 1 (PD-L1) or Programmed Cell Death Protein 1 (PD-1), and Transforming Growth Factor ? (TGF-?) (e.g. an anti-PD-(L)1(IgG):TGF?R fusion protein, comprising, for example, an anti-PD-L1 antibody and a TGF?RII or a fragment capable of binding to TGF-?).

Abstract: The invention relates to a method of treating cancer, such as head and neck cancer (e.g. head and neck squamous cell carcinoma and oropharyngeal cancer), lung cancer (e.g. non small cell lung cancer), urothelial cancer, melanoma or cervical cancer, involving the combination of an ICOS binding protein (e.g. an anti-ICOS antibody) and a PD-1 binding protein (e.g. an anti-PD-1 antibody) and optionally, a TIM-3 binding protein (e.g. an anti-TIM-3 antibody).

Abstract: The invention relates to a method of treating cancer, such as head and neck cancer (e.g. head and neck squamous cell carcinoma and oropharyngeal cancer), lung cancer (e.g. non small cell lung cancer), urothelial cancer, melanoma or cervical cancer, involving the combination of an ICOS binding protein (e.g. an anti-ICOS antibody) and a TIM-3 binding protein (e.g. an anti-TIM-3 antibody) and, optionally, a PD-1 binding protein (e.g. an anti-PD-1 antibody).

Abstract: Medispatch is a proposal for a service to provide an unmet medical need for secure universal communication between patients and their health care providers or facilities. The features of the service are security through encryption, authentication of the sender and receiver of information, and non-repudiation of the information. Through a simple e-mail interface, it will be possible to integrate the patient's medical record for the patient, their designated health care providers, and the pharmacies that fill their prescriptions. The provision of this service as a stand-alone service that can be easily integrated into any medical information services that already exist within a hospital, clinic, medical office, ambulatory surgery center, etc., is designed to allow such facilities to effectively outsource the administrative burden of this important mode of patient communication while maintaining security and HIPAA compliance.

Abstract: Immunologic assay for biological and pharmaceutical substances sets forth a universal method for the qualitative and quantitative determination of biologic and pharmaceutical substances, thus eliminating the need for multiple samples at multiple laboratories and minimizing the time factor required for such determinations. The assay is based on the recognition and binding of an antibody and an antigen or hapten to form a complex, and the changes which occur in the antibody conformation and chemical properties when such a complex is formed.A solid phase matrix, such as but not limited to a microtiter plate, is prepared having qualitative and/or quantitative spectrum of antibodies, or spectrum of antigens or haptens, bound in each position, which in the case of microtiter plates would be a sample well. The sample is then distributed to each of the positions or wells accordingly.