Abstract: A microfluidic device for processing cells for the intracellular delivery of molecules or other cargo includes a plurality of microchannels disposed in a substrate or chip and fluidically coupled to an inlet configured to receive a solution containing the cells and the molecules or other cargo to be delivered intracellularly to the cells. Each of the plurality of microchannels has one or more constriction regions therein, wherein the constriction regions comprise an omniphobic, superhydrophilic, or superhydrophobic surface. In some embodiments, multiple microfluidic devices operating in parallel are used to process large numbers of cells. The device and method has particularly applicability to delivering gene-editing molecules intracellularly to cells.

Abstract: Described herein are compounds of Formula I, wherein the variables are defined herein, their use as HSD17B13 inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, NAFLD and NASH.

Abstract: The disclosure provides compositions and methods for the Vectored Augmentation of the Destruction, Expression and/or Regulation of proteins, e.g., VA-DER systems and methods.

Abstract: A rechargeable lithium battery protection device uses an external circuit to control charging or discharging a rechargeable lithium battery for preventing an overcharge or an overdischarge of the battery. The rechargeable lithium battery protection device includes a diagnostic circuit, a light coupling circuit, a balance circuit, and an identifier circuit. The battery diagnostic circuit checks the voltage of the chargeable battery and outputs a detect signal, and then the balance circuit determines whether or not the detect signal is an overcharge signal and discharges the battery. Meanwhile, the light coupling circuit adjusts an impedance of the light coupling circuit according to the detect signal for disconnecting the battery from the external circuit and the identifier circuit provides the position of a battery that sends out the signal.

Abstract: A lithium-ion battery protection method and device controls an externally connected circuit to charge/discharge a rechargeable battery so as to prevent the rechargeable battery from over charging/discharging. The lithium-ion-ion battery protection device includes an abnormality detection circuit, a light coupling circuit, a balancing circuit, and a recognition circuit. The abnormality detection circuit is to detect the voltage of the lithium-ion-ion battery and output a detection signal. The battery continues to charge/discharge if the signal is normal, and terminate to charge/discharge if the signal is abnormal. Then, the balancing circuit determines whether the detection signal is an overcharged signal, and if yes, the rechargeable battery is discharged accordingly.

Abstract: A rechargeable lithium battery protection device uses an external circuit to control charging or discharging a rechargeable lithium battery for preventing an overcharge or an overdischarge of the battery. The rechargeable lithium battery protection device includes a diagnostic circuit, a light coupling circuit, a balance circuit, and an identifier circuit. The battery diagnostic circuit checks the voltage of the chargeable battery and outputs a detect signal, and then the balance circuit determines whether or not the detect signal is an overcharge signal and discharges the battery. Meanwhile, the light coupling circuit adjusts an impedance of the light coupling circuit according to the detect signal for disconnecting the battery from the external circuit and the identifier circuit provides the position of a battery that sends out the signal.