Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: An improved current sharing signal coupling/decoupling circuit for use in each module of a system including a plurality of parallel connected modules, each such circuit providing an interface between a module's "current sharing signal" port and a common connection bus. The signal coupling/decoupling circuits also share a common ground noted in the disclosure as a "current sharing reference". Each circuit is comprised of a variable reference based decoupling subcircuit, including a first comparator, a bi-directional switch, and a variable voltage reference, and a fixed referenced based decoupling circuit including a second comparator, a scalar resistor and a fixed voltage reference. The variable reference comparator senses the difference between the variable reference voltage and the voltage on the associated module's current sharing signal port, and activates the bi-directional switch to disconnect the module.