Patents by Inventor Steven J. Metallo

Steven J. Metallo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Linked Myc-max small molecule inhibitors
    Patent number: 8637556
    Abstract: Provided herein are compounds and compositions for interfering with the association of Myc and Max. These compounds and compositions are useful in methods for inhibiting growth or proliferation of a cell. Methods of inhibiting growth or proliferation of a cell comprise contacting the cell with an amount of a compound that interferes with Myc and Max association effective to inhibit growth or proliferation of the cell.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: January 28, 2014
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Georgetown University
    Inventors: Steven J. Metallo, Edward V. Prochownik, Ariele Viacava Follis
  • LINKED MYC-MAX SMALL MOLECULE INHIBITORS
    Publication number: 20120015989
    Abstract: Provided herein are compounds and compositions for interfering with the association of Myc and Max. These compounds and compositions are useful in methods for inhibiting growth or proliferation of a cell. Methods of inhibiting growth or proliferation of a cell comprise contacting the cell with an amount of a compound that interferes with Myc and Max association effective to inhibit growth or proliferation of the cell.
    Type: Application
    Filed: January 15, 2010
    Publication date: January 19, 2012
    Inventors: Steven J. Metallo, Edward V. Prochownik, Ariele Viacava Follis
  • Valves and pumps for microfluidic systems and method for making microfluidic systems
    Patent number: 7942160
    Abstract: The present invention relates to microfluidic systems, including valves and pumps for microfluidic systems. The valves of the invention include check valves such as diaphragm valves and flap valves. Other valves of the invention include one-use valves. The pumps of the present invention include a reservoir and at least two check valves. The reservoir may be of variable volume. The present invention also relates to a flexible microfluidic system. The present invention additionally relates to a method of making microfluidic systems including those of the present invention. The method includes forming a microfluidic system on a master, connecting a support to the microfluidic system and removing the microfluidic system from the master. The support may remain connected to the microfluidic system or the microfluidic system may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: May 17, 2011
    Assignee: President and Fellows of Harvard College
    Inventors: Noo Li Jeon, Daniel T. Chiu, Christopher J. Wargo, Insung S. Choi, Hongkai Wu, Janelle R. Anderson, George M. Whitesides, J. Cooper McDonald, Steven J. Metallo, Howard A. Stone
  • Low molecular weight Myc-max inhibitors
    Patent number: 7872027
    Abstract: Compounds and compositions for interfering with the association of Myc and Max are described herein. These compounds and compositions are useful in methods inhibiting growth or proliferation of a cell. Methods of inhibiting growth or proliferation of a cell are provided, comprising contacting the cell with an amount of a compound that interferes with Myc and Max association effective to inhibit growth or proliferation of the cell.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: January 18, 2011
    Assignees: University of Pittsburgh - Of the Commonwealth System of Higher Education, Georgetown University
    Inventors: Steven J. Metallo, Edward V. Prochownik
  • Valves and pumps for microfluidic systems and method for making microfluidic systems
    Publication number: 20040228734
    Abstract: The present invention relates to microfluidic systems, including valves and pumps for microfluidic systems. The valves of the invention include check valves such as diaphragm valves and flap valves. Other valves of the invention include one-use valves. The pumps of the present invention include a reservoir and at least two check valves. The reservoir may be of variable volume. The present invention also relates to a flexible microfluidic system. The present invention additionally relates to a method of making microfluidic systems including those of the present invention. The method includes forming a microfluidic system on a master, connecting a support to the microfluidic system and removing the microfluidic system from the master. The support may remain connected to the microfluidic system or the microfluidic system may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system.
    Type: Application
    Filed: June 14, 2004
    Publication date: November 18, 2004
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Noo Li Jeon, Daniel T. Chiu, Christopher J. Wargo, Insung S. Choi, Hongkai Wu, Janelle R. Anderson, George M. Whitesides, Justin C. McDonald, Steven J. Metallo, Howard A. Stone
  • Valves and pumps for microfluidic systems and method for making microfluidic systems
    Patent number: 6767194
    Abstract: The present invention relates to microfluidic systems, including valves and pumps for microfluidic systems. The valves of the invention include check valves such as diaphragm valves and flap valves. Other valves of the invention include one-use valves. The pumps of the present invention include a reservoir and at least two check valves. The reservoir may be of variable volume. The present invention also relates to a flexible microfluidic system. The present invention additionally relates to a method of making microfluidic systems including those of the present invention. The method includes forming a microfluidic system on a master, connecting a support to the microfluidic system and removing the microfluidic system from the master. The support may remain connected to the microfluidic system or the microfluidic system may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system.
    Type: Grant
    Filed: January 8, 2002
    Date of Patent: July 27, 2004
    Assignee: President and Fellows of Harvard College
    Inventors: Noo Li Jeon, Daniel T. Chiu, Christopher J. Wargo, Insung S. Choi, Hongkai Wu, Janelle R. Anderson, George M. Whitesides, Justin C. McDonald, Steven J. Metallo, Howard A. Stone
  • Valves and pumps for microfluidic systems and method for making microfluidic systems
    Publication number: 20020168278
    Abstract: The present invention relates to microfluidic systems, including valves and pumps for microfluidic systems. The valves of the invention include check valves such as diaphragm valves and flap valves. Other valves of the invention include one-use valves. The pumps of the present invention include a reservoir and at least two check valves. The reservoir may be of variable volume. The present invention also relates to a flexible microfluidic system. The present invention additionally relates to a method of making microfluidic systems including those of the present invention. The method includes forming a microfluidic system on a master, connecting a support to the microfluidic system and removing the microfluidic system from the master. The support may remain connected to the microfluidic system or the microfluidic system may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system.
    Type: Application
    Filed: January 8, 2002
    Publication date: November 14, 2002
    Inventors: Noo Li Jeon, Daniel T. Chiu, Christopher J. Wargo, Insung S. Choi, Hongkai Wu, Janelle R. Anderson, George M. Whitesides, Justin C. McDonald, Steven J. Metallo, Howard A. Stone