Patents by Inventor Steven J. Saul
Steven J. Saul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220236151Abstract: A method for extracting a mycotoxin, when present, from a sample. Compositions and methods include the use of high ionic strength compositions including compositions that include many amine and/or carboxyl groups such as protein based, amino acid based and polyethylene glycol based composition.Type: ApplicationFiled: January 31, 2022Publication date: July 28, 2022Applicant: Charm Sciences, Inc.Inventors: John Jabour, Steven J. Saul, Mark E. Tess
-
Patent number: 11035764Abstract: A method and composition for extracting an analyte from a test sample such as grain, so as to determine whether the test sample is contaminated with a toxin. The method is particularly useful for detecting the presence in a batch of grain of a mycotoxin, such as for example aflatoxin, ochratoxin, T2, zearalanone, vomitoxin (deoxynivalenol a/k/a DON), patulin and fumonisin. Extraction is performed with use of a composition that includes a proteinaceous material, such as albumin, as an extraction agent.Type: GrantFiled: February 4, 2013Date of Patent: June 15, 2021Assignee: Charm Sciences, Inc.Inventors: John Jabour, Steven J. Saul, Mark E. Tess
-
Publication number: 20190293527Abstract: A method for extracting a mycotoxin, when present, from a sample. Compositions and methods include the use of high ionic strength compositions including compositions that include many amine and/or carboxyl groups such as protein based, amino acid based and polyethylene glycol based composition.Type: ApplicationFiled: October 31, 2018Publication date: September 26, 2019Applicant: Charm Sciences, Inc.Inventors: JOHN JABOUR, Steven J. Saul, Mark E. Tess
-
Patent number: 9562898Abstract: Embodiments described herein include methods and assays for detecting beta-lactam analytes and mycotoxin analytes in a sample. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some embodiments, the multiple control zone capture agents capture a plurality of binders within one control zone. Test results are determined by comparison of the control zone signal to a test zone signal.Type: GrantFiled: August 18, 2014Date of Patent: February 7, 2017Assignee: Charm Sciences, Inc.Inventors: Steven J. Saul, Robert J. Markovsky, David W. Douglas
-
Patent number: 9234889Abstract: A method and test strip for detecting one or more analytes in a test solution. The method and test strip include a detectable component, such as a gold particle, that is linked to a binder, such as an antibody, through a linkage. The linkage can include an antibody binding protein and an antispecies antibody.Type: GrantFiled: December 17, 2009Date of Patent: January 12, 2016Assignee: Charm Sciences, Inc.Inventors: Steven J. Saul, David W. Douglas
-
Patent number: 9063137Abstract: Embodiments described herein include methods and assays for detecting an analyte in a sample using a plurality of control zone capture agents. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some embodiments, the multiple control zone capture agents capture a plurality of binders within one control zone. Test results are determined by comparison of the control zone signal to a test zone signal.Type: GrantFiled: November 29, 2010Date of Patent: June 23, 2015Assignee: Charm Sciences, Inc.Inventors: Steven J. Saul, Robert J. Markovsky, David W. Douglas
-
Patent number: 9057724Abstract: Label complexes, lateral flow apparatus and methods of detecting a high molecular weight substance are shown and described. In one embodiment, the label complex includes an antispecies antibody and another antibody having sensitivity to both the antispecies antibody and to a control line capture agent, an antibody binding protein and a detectable component. Typically, the antibody binding protein may bind to a receptor for the analyte or to the anti-species antibody. In yet other embodiments, a lateral flow test strip includes the label complex and a solid support that traverses lateral flow of a liquid sample and provides a detectable signal.Type: GrantFiled: May 23, 2012Date of Patent: June 16, 2015Assignee: Charm Sciences, Inc.Inventor: Steven J. Saul
-
Publication number: 20140356978Abstract: A method and composition for extracting an analyte from a test sample such as grain, so as to determine whether the test sample is contaminated with a toxin. The method is particularly useful for detecting the presence in a batch of grain of a mycotoxin, such as for example aflatoxin, ochratoxin, T2, zearalanone, vomitoxin (deoxynivalenol a/k/a DON), patulin and fumonisin. Extraction is performed with use of a composition that includes a proteinaceous material, such as albumin, as an extraction agent.Type: ApplicationFiled: February 4, 2013Publication date: December 4, 2014Applicant: Charm Sciences, Inc.Inventors: John Jabour, Steven J. Saul, Mark E. Tess
-
Publication number: 20140206100Abstract: Label complexes, lateral flow apparatus and methods of detecting a high molecular weight substance are shown and described. In one embodiment, the label complex includes an antispecies antibody and another antibody having sensitivity to both the antispecies antibody and to a control line capture agent, an antibody binding protein and a detectable component. Typically, the antibody binding protein may bind to a receptor for the analyte or to the anti-species antibody. In yet other embodiments, a lateral flow test strip includes the label complex and a solid support that traverses lateral flow of a liquid sample and provides a detectable signal.Type: ApplicationFiled: May 23, 2012Publication date: July 24, 2014Applicant: Charm Sciences, Inc.Inventor: Steven J. Saul
-
Patent number: 8709792Abstract: A method and device for detecting analytes in a test sample. Embodiments include methods for quantitatively detecting analytes within a range of concentrations. In an embodiment the method includes a lateral flow test strip with multiple test areas for capturing a labeled receptor to provide a detectable signal.Type: GrantFiled: July 23, 2010Date of Patent: April 29, 2014Assignee: Charm Sciences, Inc.Inventors: Steven J. Saul, Mark E. Tess, Robert J. Markovsky
-
Patent number: 8592171Abstract: Embodiments described herein include methods and assays for detecting an analyte in a sample using a plurality of control zone capture agents. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some embodiments, the multiple control zone capture agents capture a plurality of binders within one control zone. Test results are determined by comparison of the control zone signal to a test zone signal.Type: GrantFiled: June 11, 2012Date of Patent: November 26, 2013Assignee: Charm Sciences, Inc.Inventors: Steven J. Saul, Robert J. Markovsky, David W. Douglas
-
Publication number: 20130295691Abstract: The invention features a method of attaching a ligand that has a free carboxyl group to a solid support by adding an amino group to the ligand to form a ligand-amino derivative, converting the ligand amino derivative to a ligand sulfhydryl derivative, attaching the ligand sulfhydryl derivative to a protein to form a ligand-linker-protein conjugate, and applying the ligand-linker-protein conjugate to the solid support. The method is particularly useful for immobilizing small molecule ligands having a free carboxyl group, such as cloxicillin, to a lateral-flow test strip, in order to make a detection zone on the test strip that exhibits a clear signal and enhanced sensitivity.Type: ApplicationFiled: July 8, 2013Publication date: November 7, 2013Inventor: Steven J. Saul
-
Patent number: 8481334Abstract: The invention features a method of attaching a ligand that has a free carboxyl group to a solid support by adding an amino group to the ligand to form a ligand-amino derivative, converting the ligand amino derivative to a ligand sulfhydryl derivative, attaching the ligand sulfhydryl derivative to a protein to form a ligand-linker-protein conjugate, and applying the ligand-linker-protein conjugate to the solid support. The method is particularly useful for immobilizing small molecule ligands having a free carboxyl group, such as cloxicillin, to a lateral-flow test strip, in order to make a detection zone on the test strip that exhibits a clear signal and enhanced sensitivity.Type: GrantFiled: March 31, 2008Date of Patent: July 9, 2013Assignee: Charm Sciences, Inc.Inventor: Steven J. Saul
-
Patent number: 8476064Abstract: An aspect of the disclosure is a method and device for the detection of antibiotics in a sample. Embodiments include a microbial culture with growth indicators and sensitivity adjustment reagents. Adjustment reagents include a variety of antibiotic binders that can be added to microbial culture to reduce sensitivity to certain antibiotics. Some embodiments include multiple buffers with a variety of pKa ranges. Some embodiments also include a complete self-contained apparatus for sampling and testing.Type: GrantFiled: July 26, 2010Date of Patent: July 2, 2013Assignee: Charm Sciences, Inc.Inventors: Robert S. Salter, Steven J. Saul, Martin T. Rossi
-
Publication number: 20130059399Abstract: A method and device for detecting analytes in a test sample. Embodiments include methods for quantitatively detecting analytes within a range of concentrations. In an embodiment the method includes a lateral flow test strip with multiple test areas for capturing a labeled receptor to provide a detectable signal.Type: ApplicationFiled: July 23, 2010Publication date: March 7, 2013Inventors: Steven J. Saul, Mark E. Tess, Robert J. Markovsky
-
Patent number: 8236515Abstract: Methods are provided for detection of concentrations of less than 3.4 picomolar of adenosine triphosphate (ATP) using recombinant luciferase in the luciferin-luciferase reaction. Aspects include a low pH composition for use in detecting the presence of ATP. The low pH composition can include low concentrations of detergents and can be used in combination with methods for reading, calculating and interpreting luminescence generated by the ATP-luciferin-luciferase reaction.Type: GrantFiled: September 27, 2010Date of Patent: August 7, 2012Assignee: Charm Sciences, Inc.Inventors: Stanley E. Charm, Cheryl B. Francisco, Robert J. Markovsky, Robert S. Salter, Steven J. Saul
-
Publication number: 20110070127Abstract: Embodiments described herein include methods and assays for detecting an analyte in a sample using a plurality of control zone capture agents. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some embodiments, the multiple control zone capture agents capture a plurality of binders within one control zone. Test results are determined by comparison of the control zone signal to a test zone signal.Type: ApplicationFiled: November 29, 2010Publication date: March 24, 2011Inventors: Steven J. Saul, Robert J. Markovsky, David W. Douglas
-
Publication number: 20110065116Abstract: Methods are provided for detection of concentrations of less than 3.4 picomolar of adenosine triphosphate (ATP) using recombinant luciferase in the luciferin-luciferase reaction. Aspects include a low pH composition for use in detecting the presence of ATP. The low pH composition can include low concentrations of detergents and can be used in combination with methods for reading, calculating and interpreting luminescence generated by the ATP-luciferin-luciferase reaction.Type: ApplicationFiled: September 27, 2010Publication date: March 17, 2011Inventors: Stanley E. Charm, Cheryl B. Francisco, Robert J. Markovsky, Robert S. Salter, Steven J. Saul
-
Patent number: 7897365Abstract: The present invention relates to a method for adjusting the sensitivity of a microbial culture to an antibiotic. The method employs a substance derived from a bacterial species with sensitivity to the antibiotic. Such bacterial species include the same species used in the culture or a different species.Type: GrantFiled: November 5, 2004Date of Patent: March 1, 2011Assignee: Charm Sciences, Inc.Inventors: Robert S. Salter, Steven J. Saul, Martin T. Rossi, Robert J. Markovsky
-
Patent number: 7863057Abstract: Embodiments described herein include methods and assays for detecting an analyte in a sample using a plurality of control zone capture agents. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some embodiments, the multiple control zone capture agents capture a plurality of binders within one control zone. Test results are determined by comparison of the control zone signal to a test zone signal.Type: GrantFiled: July 8, 2008Date of Patent: January 4, 2011Assignee: Charm Sciences, Inc.Inventors: Steven J. Saul, Robert J. Markovsky, David W. Douglas