Patents by Inventor Steven Jacobsen
Steven Jacobsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11950853Abstract: An electromagnetic device includes a jig and multiple wires. The jig includes a center member and coil-separating blocks. The coil-separating blocks protrude from the center member and are separated from each other to provide a coil channels. Each of the wires is wrapped on the jig, around the center member, and in one of the coil channels to form one of a multiple coils. Each of the coils is configured to connect to an electromagnetic navigation system and generate respective electromagnetic fields to be emitted relative to a subject.Type: GrantFiled: October 7, 2020Date of Patent: April 9, 2024Assignee: Medtronic Navigation, Inc.Inventors: Andrew Wald, Bruce M. Burg, Steven L. Hartmann, Brad Jacobsen, Jeffrey Swetnam
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Patent number: 9644025Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.Type: GrantFiled: October 17, 2008Date of Patent: May 9, 2017Assignees: WYETH LLC, JANSSEN SCIENCES IRELAND UCInventors: Ronald Black, Lars Ekman, Ivan Lieberburg, Michael Grundman, James Callaway, Keith M. Gregg, Jack Steven Jacobsen, Davinder Gill, Lioudmila Tchistiakova, Angela Widom
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Patent number: 9272030Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered is monitored by measuring levels of tau.Type: GrantFiled: April 22, 2011Date of Patent: March 1, 2016Assignees: JANSSEN SCIENCES IRELAND UC, WYETH LLCInventors: Ronald Black, Jack Steven Jacobsen, Lioudmila Tchistiakova, Angela Widom, Davinder Gill, Lars Ekman, Ivan Lieberburg, Michael Grundman, James Callaway, Keith M. Gregg, Wagner Zago, Manuel J. Buttini, Gene G. Kinney
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Publication number: 20150118223Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered is monitored by measuring levels of tau.Type: ApplicationFiled: April 22, 2011Publication date: April 30, 2015Applicants: WYETH LLC, JANSSEN ALZHEIMER IMMUNOTHERAPYInventors: Ronald Black, Jack Steven Jacobsen, Lioudmila Tchistiakova, Angela Widom, Davinder Gill, Lars Ekman, Ivan Lieberburg, Michael Grundman, James Callaway, Keith M. Gregg, Wagner Zago, Manuel J. Buttini, Gene G. Kinney
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Patent number: 8916165Abstract: The invention provides improved agents and methods for treatment of diseases associated with beta amyloid (A?). Preferred agents include antibodies, e.g., humanized antibodies specific for A?.Type: GrantFiled: December 15, 2005Date of Patent: December 23, 2014Assignees: Janssen Alzheimer Immunotherapy, Wyeth LLCInventors: Guriq Basi, Jack Steven Jacobsen
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Publication number: 20130209453Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered is monitored by measuring levels of tau.Type: ApplicationFiled: April 22, 2011Publication date: August 15, 2013Applicants: WYETH LLC, JANSSEN ALZHEIMER IMMUNOTHERAPYInventors: Ronald Black, Jack Steven Jacobsen, Lioudmila Tchistiakova, Angela Widom, Davinder Gill, Lars Ekman, Ivan Lieberburg, Michael Grundman, James Callaway, Keith M. Gregg, Wagner Zago, Manuel J. Buttini
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Publication number: 20120070379Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.Type: ApplicationFiled: September 13, 2011Publication date: March 22, 2012Applicants: Janssen Alzheimer Immunotherapy, Wyeth LLCInventors: Ronald Black, Lars Ekman, Ivan Lieberburg, Michael Grundman, James Callaway, Keith M. Gregg, Jack Steven Jacobsen, Davinder Gill, Lioudmila Tchistiakova, Angela Widom
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Publication number: 20100266505Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.Type: ApplicationFiled: October 17, 2008Publication date: October 21, 2010Applicants: Wyeth LLC, Janssen Alzheimer ImmunotherapyInventors: Ronald Black, Lars Ekman, Ivan Lieberburg, Michael Grundman, James Callaway, Keith M. Gregg, Jack Steven Jacobsen, Davinder Gill, Lioudmila Tchistiakova, Angela Widom
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Patent number: 7625560Abstract: The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of A? in the brain of a patient. Preferred agents include antibodies, e.g., humanized antibodies.Type: GrantFiled: December 15, 2005Date of Patent: December 1, 2009Assignee: Janssen Alzheimer ImmunotherapyInventors: Guriq Basi, Jack Steven Jacobsen
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Publication number: 20090155256Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.Type: ApplicationFiled: October 17, 2008Publication date: June 18, 2009Applicants: Wyeth, Elan Pharma International LimitedInventors: Ronald Black, Lars Ekman, Ivan Lieberburg, Michael Grundman, James Callaway, Keith M. Gregg, Jack Steven Jacobsen, Davinder Gill, Lioudmila Tchistiakova, Angela Widom
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Publication number: 20060195105Abstract: A tool for separating an acetabular shell of a hip prosthesis from the surrounding pelvic bone includes a fixture which attaches to the acetabular shell and has a chisel guide mounted on it. A chisel associated with the chisel guide is curved to conform to the outer periphery of the acetabular shell, and the chisel guide causes the chisel to circumscribe the acetabular shell as the chisel is inserted between the acetabular shell and the pelvis.Type: ApplicationFiled: January 28, 2005Publication date: August 31, 2006Inventors: Steven Teeny, Steven Jacobsen
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Publication number: 20040248775Abstract: The present invention addresses a need in the art for methods of identifying apoptotic proteins and methods for screening compounds which inhibit an apoptotic protein. More particularly, in certain embodiments, the invention relates to increased expression levels of a NALP1 gene and/or a NALP5 gene following neuron injury. In other embodiments, the present invention demonstrates that the recombinant expression of NALP1 and/or NALP5 polynucleotides stimulates apoptosis in cultured neurons, HeLa cells and NIH-3T3 cells. In yet other embodiments, the invention relates to mutations in the nucleotide binding sequence (NBS) of a NALP1 or a NALP5 polypeptide, wherein these NBS mutations inhibit purine nucleotide binding and reduce caspase activation.Type: ApplicationFiled: June 3, 2004Publication date: December 9, 2004Applicant: WyethInventors: Bradley Alton Ozenberger, Sanford Jay Silverman, Jack Steven Jacobsen, Feng Liu, Saule Naureckiene
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Patent number: 5703209Abstract: This application describes a purified and isolated fragment of a nucleic acid molecule encoding an amyloid precursor mutein, wherein the fragment comprises a nucleic acid sequence encoding at least one marker and a nucleic acid sequence of about 419, about 475 or about 494 amino acid residues in which a portion thereof encodes a .beta.-amyloid protein domain. Also described is a method for screening for a compound which reduces the formation of .beta.-amyloid protein.Type: GrantFiled: June 5, 1995Date of Patent: December 30, 1997Assignee: American Cyanamid CompanyInventors: Michael Peter Vitek, Jack Steven Jacobsen
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Patent number: 5693478Abstract: This disclosure concerns a method of detecting the presence of a polypeptide in a sample wherein the polypeptide is encoded by a fragment of a nucleic acid molecule encoding an amyloid precursor mutein and the fragment comprises a sequence encoding at least one marker and a sequence encoding about 419 amino acid residues of the APP-695 isoform, about 475 amino acid residues of the APP-751 isoform or about 494 amino acid residues of the APP-770 isoform. The method encompasses contacting the sample with an antibody, which specifically binds the marker or the amyloid precursor mutein, under suitable conditions to favor the formation of an antibody-antigen complex and detecting the presence of any complex thus formed. The disclosure also deals with the method employing the above nucleic acid fragment wherein the amino acid residues from position 11 to position 28 are deleted from the portion of the sequence encoding the .beta.Type: GrantFiled: June 5, 1995Date of Patent: December 2, 1997Assignee: American Cyanamid CompanyInventors: Michael Peter Vitek, Jack Steven Jacobsen
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Patent number: 5656477Abstract: This application describes a purified and isolated fragment of a nucleic acid molecule encoding an amyloid precursor mutein, wherein the fragment comprises a nucleic acid sequence encoding at least one marker and a nucleic acid sequence of about 419, about 475 or about 494 amino acid residues in which a portion thereof encodes a .beta.-amyloid protein domain. Also described is a method for screening for a compound which reduces the formation of .beta.-amyloid protein.Type: GrantFiled: September 20, 1993Date of Patent: August 12, 1997Assignee: American Cyanamid CompanyInventors: Michael Peter Vitek, Jack Steven Jacobsen
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Patent number: 5652092Abstract: This application describes a purified and isolated fragment of a nucleic acid molecule encoding an amyloid precursor mutein, wherein the fragment comprises a nucleic acid sequence encoding at least one marker and a nucleic acid sequence of about 419, about 475 or about 494 amino acid residues in which a portion thereof encodes a .beta.-amyloid protein domain. Also described is a method for screening for a compound which reduces the formation of .beta.-amyloid protein.Type: GrantFiled: June 5, 1995Date of Patent: July 29, 1997Assignee: American Cyanamid CompanyInventors: Michael Peter Vitek, Jack Steven Jacobsen
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Patent number: 4423732Abstract: A sterile packaging system for an implantable cardiac pacer or tissue stimulator has a ribbon-like electrical connector strip that permits testing and use of the pacer while it remains sealed in a sterile container. The strip is a thin film of a flexible, non-conductive material with a set of longitudinally oriented conductive paths formed on one surface. A nested set of vacuum formed, plastic blister packs surround and secure the pacer. Each blister pack has a removable closure secured to its periphery. The pack and sealant are impervious to biological contaminants. The closure is preferably a film material that is pervious to a sterilizing agent. The connector strip is preferably two strips, each extending through the peripheral seal of one of the packs. The conductive paths of each strip are in series electrical connection when the packs are assembled.Type: GrantFiled: February 12, 1981Date of Patent: January 3, 1984Assignee: Cordis CorporationInventors: Peter P. Tarjan, Marvin L. Sussman, Steven Jacobsen