Abstract: Compounds, such as compounds having Formula (I): wherein each variable is as described herein, that modulate the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.

Abstract: The present disclosure relates to a device for meniscal repair for use in areas of a human body where tissue can either be surgically reattached to bone or surgically repaired when a tear forms in the tissue. The device may take one of three forms; in a first form, the device comprises a handle and a deployment member permitting the deployment of anchors or sutures to the tissue requiring repair; subsequently the device may take a second form comprising the handle, still in place, and a cutter member for manipulating and cutting anchors and sutures to assist in repair of the tissue; in its third form, the device comprises the handle, still in place, and a fluid injection member for applying a fluid to aid in improving biological conditions for the tissue to heal.

Abstract: Provided is a bone plate for the olecranon of the proximal ulna using a combination of screws and K wires. The plate is curved to fit the shape of the olecranon and is screwed in place. The plate has a locking section located in the curved section. A fastener is pushed over the ends of the K wires and locks in to the locking section of the plate. The fastener has a tapered wedge that secures the K wires allowing fixation to the plate and resists their withdrawal. A femoral stem cap is used during hip replacement surgery and protects the Morse taper of the femoral stem once the ball of the hip joint is removed. The femoral stem cap has an air vent to allow air to pass when being applied and removed.

Abstract: A bone plate is provided for the distal humerus, the plate having a main shank portion with one or more screw holes. The main shank portion bends to form an off-axis shank portion that is free of screw holes. The off-axis portion twists 90 degrees to form a distal shank portion. A barrel formed on the distal shank portion allows for the insertion of a bone screw. The bone plate is thus affixed in two perpendicular planes by screwing the lower shaft portion to the humeral shaft and passing the bone screw through the distal humerus into the bevelled barrel.