Patents by Inventor Steven M. Lipkin

Steven M. Lipkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mammal with an orthotopic tumor capable of metastasis, a method of making and a method of using
    Patent number: 9681647
    Abstract: Provided are compositions and methods that involve cancer cells which are modified so that they can form orthotopic tumors in a non-human mammal, and wherein metastasis of the tumor can be controlled. The cancer cells, which may be human cancer cells, are modified so that expression of a human chemokine receptor can be modulated. Modulating expression of the human chemokine receptor allows selective initiation of metastasis. Kits which contain the modified cancer cells are provided. A method for identifying agents which can inhibit metastasis using non-human mammals having orthotopic tumors formed using the modified cancer cells is also included.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: June 20, 2017
    Assignee: Cornell University
    Inventors: Huanhuan Chen, Steven M. Lipkin, Xiling Shen
  • COMPOSITIONS AND METHODS USEFUL FOR MAKING ORTHOTOPIC TUMORS WITH CONTROLLABLE METASTASIS
    Publication number: 20150164053
    Abstract: Provided are compositions and methods that involve cancer cells which are modified so that they can form orthotopic tumors in a non-human mammal, and wherein metastasis of the tumor can be controlled. The cancer cells, which may be human cancer cells, are modified so that expression of a human chemokine receptor can be modulated. Modulating expression of the human chemokine receptor allows selective initiation of metastasis. Kits which contain the modified cancer cells are provided. A method for identifying agents which can inhibit metastasis using non-human mammals having orthotopic tumors formed using the modified cancer cells is also included.
    Type: Application
    Filed: July 3, 2013
    Publication date: June 18, 2015
    Inventors: Huanhuan Chen, Steven M. Lipkin, Xiling Shen
  • IDENTIFICATION OF SUBJECTS LIKELY TO BENEFIT FROM STATIN THERAPY
    Publication number: 20100280056
    Abstract: Methods are provided herein to determine if a subject is a candidate for treatment with an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). The method includes determining the presence of at least one polymorphism in the HMGCR gene in a sample from a subject. The presence of at least one polymorphism indicates that the subject is a candidate for treatment with a statin, for example to decrease risk of or treat cancer, cardiovascular disease, diabetes, obesity, inflammatory disease, or auto-immune disease.
    Type: Application
    Filed: November 4, 2008
    Publication date: November 4, 2010
    Inventors: Levy Kopelovich, Steven M. Lipkin, Gad Rennert, Stephen B. Gruber, Victor Moreno