Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their,preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

Abstract: A display center for a weapons control system consisting of a frame including front leg rails, rear leg rails, side rail supports, a top plate, a rear cross-bracket, a bottom plate, a monitor area and a removable electronics box. The display center may include an upper monitor, a lower monitor and a monitor support and an integrated keyboard and trackball.

Abstract: A method of accounting for errors in the altitude reporting of a terrain alert and warning system (TAWS) is disclosed wherein errors due to non-standard atmospheric conditions, incorrect altimeter setting and air data computer (ADC) sensor error are detected and corrected for by compensating ADC altitudes for cold temperatures as well as using global positioning system (GPS) altitude data to confirm the accuracy of the ADC altitude information at all times.

Abstract: A combination toilet seat and bidet apparatus includes a toilet seat member formed with a top wall, a continuous arcuate outer sidewall extending between opposite ends of a back wall and an inner sidewall defining, in part, a seat opening. An arcuate nozzle support arm is mounted on the seat member for rotation about an axis generally normal to the longitudinal axis of the seat member. An operating handle is connected to the arm at one side of the seat and a water flow control valve and operating handle are mounted on the seat opposite the arm operating handle for controlling water flow to a water jet nozzle mounted on the arm. The arm is adapted to be moved to selected working positions by the arm operating handle, and water flow may be selectively varied at will.

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their,preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).