Abstract: In one aspect, a process for producing a biofuel comprises reacting a feed material that comprises a glyceride with an alcohol in the presence of a catalytic composition such that at least some of the glyceride in the feed material is converted into a biofuel mixture that comprises glycerol and the corresponding alcoholic ester of the glyceride. The catalytic composition comprises a heterogeneous catalyst and a homogeneous catalyst. The heterogeneous catalyst and the homogeneous catalyst have a synergistic effect in catalyzing the reaction of the glyceride in the feed material with the alcohol.