Patents by Inventor Steven P. Balk

Steven P. Balk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TREATMENT OF METABOLIC DISORDERS
    Publication number: 20180296671
    Abstract: The present invention relates to the discovery that increases in invariant NKT cell (iNKT) number and/or activity can reduce the incidence or severity of metabolic disorders such as obesity and diabetes. The invention accordingly features methods, kits, and compositions for the treatment of such metabolic disorders by administration of a composition capable of increasing iNKT activity.
    Type: Application
    Filed: March 5, 2018
    Publication date: October 18, 2018
    Inventors: Mark A. EXLEY, Lydia LYNCH, Donal O'SHEA, Cliona O'FARRELLY, Steven P. BALK
  • Methods and compositions for treatment of metabolic disorders
    Patent number: 9907848
    Abstract: The present invention relates to the discovery that increases in invariant NKT cell (iNKT) number and/or activity can reduce the incidence or severity of metabolic disorders such as obesity and diabetes. The invention accordingly features methods, kits, and compositions for the treatment of such metabolic disorders by administration of a composition capable of increasing iNKT activity.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: March 6, 2018
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Mark A. Exley, Lydia Lynch, Donal O'Shea, Cliona O'Farrelly, Steven P. Balk
  • COMPOSITIONS AND METHODS OF MONOCLONAL AND POLYCLONAL ANTIBODIES SPECIFIC FOR T CELL SUBPOPULATIONS
    Publication number: 20150299320
    Abstract: The invention provides compounds and methods for the ex vivo or in vivo expansion of NK T cells, CD1d-reactive T cells, and J?Q+ T cells, and the modulation of their activities. These compounds and methods have diagnostic and therapeutic applications.
    Type: Application
    Filed: September 24, 2014
    Publication date: October 22, 2015
    Inventors: Mark A. Exley, Samuel B. Wilson, Steven P. Balk
  • ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20140088187
    Abstract: The present invention relates to novel aryl sulfonamide compounds use of such compounds in the inhibition of androgen receptor and in the treatment of various diseases, disorders or conditions related to androgen receptor.
    Type: Application
    Filed: December 14, 2011
    Publication date: March 27, 2014
    Applicant: BETH ISRAEL DEACONESS MEDICAL CENTER
    Inventors: Alan C. Rigby, Steven P. Balk, Kumaran Shanmugasundaram, Howard C. Shen
  • METHODS AND COMPOSITIONS FOR TREATMENT OF METABOLIC DISORDERS
    Publication number: 20140079771
    Abstract: The present invention relates to the discovery that increases in invariant NKT cell (iNKT) number and/or activity can reduce the incidence or severity of metabolic disorders such as obesity and diabetes. The invention accordingly features methods, kits, and compositions for the treatment of such metabolic disorders by administration of a composition capable of increasing iNKT activity.
    Type: Application
    Filed: September 9, 2013
    Publication date: March 20, 2014
    Applicant: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Mark A. EXLEY, Lydia Lynch, Donal O'Shea, Cliona O'Farrelly, Steven P. Balk
  • COMPOSITIONS AND METHODS OF MONOCLONAL AND POLYCLONAL ANTIBODIES SPECIFIC FOR T CELL SUBPOPULATIONS
    Publication number: 20120258040
    Abstract: The invention provides compounds and methods for the ex vivo or in vivo expansion of NK T cells, CD1d-reactive T cells, and J?Q+ T cells, and the modulation of their activities. These compounds and methods have diagnostic and therapeutic applications.
    Type: Application
    Filed: March 19, 2012
    Publication date: October 11, 2012
    Applicants: Beth Israel Deaconess Medical Center, Inc, The General Hospital Corporation, Dana Farber Cancer Institute
    Inventors: Mark A. Exley, Samuel B. Wilson, Steven P. Balk
  • USE OF ANTI-CD1 ANTIBODIES FOR THE MODULATION OF IMMUNE RESPONSES
    Publication number: 20120164138
    Abstract: The invention provides methods for the administration of an anti-CD1 antibody for the treatment or prevention of a variety of disorders, such as autoimmune disease, viral infection, bacterial infection, parasitic infection, infection by a eukaryotic pathogen, allergy, asthma, inflammatory condition, graft versus host disease, graft rejection, immunodeficiency disease, spontaneous abortion, pregnancy, and cancer.
    Type: Application
    Filed: December 6, 2011
    Publication date: June 28, 2012
    Applicant: Beth Israel Deaconess Medical Center
    Inventors: Mark A. Exley, Steven P. Balk, Simon C. Yue
  • Compositions and methods of monoclonal and polyclonal antibodies specific for T cell subpopulations
    Patent number: 8138314
    Abstract: The invention provides compounds and methods for the ex vivo or in vivo expansion of NK T cells, CD1d-reactive T cells, and J?Q+ T cells, and the modulation of their activities. These compounds and methods have diagnostic and therapeutic applications.
    Type: Grant
    Filed: October 2, 2006
    Date of Patent: March 20, 2012
    Assignees: Beth Israel Deaconess Medical Center, Inc., Dana-Farber Cancer Institute, The General Hospital Corporation
    Inventors: Mark A. Exley, Samuel B. Wilson, Steven P. Balk
  • Use of anti-CD1 antibodies for the modulation of immune responses
    Patent number: 8084020
    Abstract: The invention provides methods for the administration of an anti-CD 1 antibody for the treatment or prevention of a variety of disorders, such as autoimmune disease, viral infection, bacterial infection, parasitic infection, infection by a eukaryotic pathogen, allergy, asthma, inflammatory condition, graft versus host disease, graft rejection, immunodeficiency disease, spontaneous abortion, pregnancy, and cancer.
    Type: Grant
    Filed: May 1, 2003
    Date of Patent: December 27, 2011
    Assignee: Beth Israel Deaconess Medical Center
    Inventors: Mark A. Exley, Steven P. Balk, Simon C. Yue
  • Compositions and methods of monoclonal and polyclonal antibodies specific for T cell subpopulations
    Publication number: 20020164331
    Abstract: The invention provides compounds and methods for the ex vivo or in vivo expansion of NK T cells, CD1d-reactive T cells, and J&agr;Q+ T cells, and the modulation of their activities. These compounds and methods have diagnostic and therapeutic applications.
    Type: Application
    Filed: June 19, 2001
    Publication date: November 7, 2002
    Inventors: Mark A. Exley, Samuel B. Wilson, Steven P. Balk