Abstract: Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.

Abstract: Provided herein are RET kinase inhibitors according to the formula: pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods for their use in the treatment of diseases that can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. A, R1, n, X1, X2, X3, X4, and R2 have the meanings given in the specification.

Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: A headrest is supported by a first rod and a second rod, the first rod being equipped with a series of positioning notches on a first side and a retaining notch on a second side. In operation, the two rods are installed into two channels in the seat, one of the channels being equipped with a headrest guide assembly. The headrest guide assembly includes a button that allows the user to selectively engage the series of positioning notches on the first side of the first rod so that the headrest can be positioned as desired. However, the headrest guide assembly will automatically engage the retaining notch on the second side and thus prevent the headrest from being removed from the seat. To remove the headrest, a tool can be inserted into a notch in the button and to insertion of the tool prevents the headrest guide assembly from engaging the retaining notch on the second side and thus the headrest can be removed.