Abstract: Disclosed herein are robust disposable alternating tangential flow (ATF) housing and diaphragm pump units and associated methods of manufacturing, testing, wetting, and using the same.

Abstract: Disclosed herein are robust disposable alternating tangential flow (ATF) housing and diaphragm pump units and associated methods of manufacturing, testing, wetting, and using the same.

Abstract: Disclosed herein are robust disposable alternating tangential flow (ATF) housing and diaphragm pump units and associated methods of manufacturing, testing, wetting, and using the same.

Abstract: Disclosed herein are robust disposable alternating tangential flow (ATF) housing and diaphragm pump units and associated methods of manufacturing, testing, wetting, and using the same.

Abstract: The present invention provides methods for producing single and multi-layered coiled hollow fiber bundles for use in separation modules whose performance can be predicted, said modules being designed to take advantage of the benefits of Dean vortices. The present invention is also directed to multi-layered coiled hollow fiber bundles for use in separation modules that are directly scalable because each layer performs substantially equivalently to the other layers when subjected to a fluid of a certain velocity such that Dean vortices are created.

Abstract: One or more hollow fiber membranes having a coflow of filtrate to provide trans-membrane pressure (TMP) control. The membranes preferably are capable or forming a shear effect or Dean vortices at their inner surface. Optionally, the filtrate channel may contain one or more types of beads, either inert or formed of a capture resin such as affinity chromatography beads or ion exchange resins, for selectively capturing and retaining certain molecules from the filtrate of feedstream. The beads, in addition to the optional capture function, aid in the control of the TMP.

Abstract: A filter construction is provided having a packing density of at least 300 square meters of active membrane filter area per cubic meter of external volume of said filter construction, said filter constructed of materials characterized by less than 250 mg of extracted contamination per m2 of wetted material.

Abstract: A filtration apparatus is provided which is formed from multilayer presealed elements and monolayer elements that are insert molded together. The device is provided with a feed port, a filtrate port and, optionally, a retentate port. The sealing configuration of the presealed elements and the seal provided by the insert molding step effect a seal configuration that causes a feed liquid to be filtered to form a filtrate such that the filtrate is not mixed with either the feed or a retentate.

Abstract: A heat exchange apparatus is provided which is formed from at least one multilayer presealed element and at least one monolayer element that are insert molded together. The heat exchange apparatus is provided with an inlet and an outlet for a process fluid and at least one inlet and at least one outlet for a heat exchange fluid. The sealing configuration of the presealed elements and the seal provided by the insert molding effect a seal configuration that causes heat to be transferred between the process fluid and the heat exchange fluid while preventing mass transfer between the two fluids.

Abstract: A filtration apparatus for deadend filtration is provided which is formed from multilayer presealed elements and monolayer elements that are insert molded together. The device is provided with a feed port, and a filtrate port. The sealing configuration of the presealed elements and the seal provided by the insert molding step effect a seal configuration that causes a feed liquid to be filtered to form a filtrate such that the filtrate is not mixed with the feed.

Abstract: A heat exchange apparatus is provided which is formed from at least one multilayer presealed element and at least one monolayer element that are insert molded together. The heat exchange apparatus is provided with an inlet and an outlet for a process fluid and at least one inlet and at least one outlet for a heat exchange fluid. The sealing configuration of the presealed elements and the seal provided by the insert molding effect a seal configuration that causes heat to be transferred between the process fluid and the heat exchange fluid while preventing mass transfer between the two fluids.

Abstract: A filtration apparatus is provided which is formed from multilayer presealed elements and monolayer elements that are insert molded together. The device is provided with a feed port, a filtrate port and, optionally, a retentate port. The sealing configuration of the presealed elements and the seal provided by the insert molding step effect a seal configuration that causes a feed liquid to be filtered to form a filtrate such that the filtrate is not mixed with either the feed or a retentate.

Abstract: A manifold segment is provided for tangential flow filtration apparatus. The manifold segment includes a fluid feed conduit, a retentate conduit, a filtrate inlet and a filtrate outlet. An adaptor manifold is provided which directs filtrate from the manifold segment into a tangential flow filtration module and directs filtrate from the module into the manifold segment. Filtrate introduced into the tangential flow filtrate module reduces pressure drop across a filter layer in the module.

Abstract: A spiral wound filtration cartridge construction is provided which includes a cartridge positioned within a solid outer cylinder which, in turn is positioned within a solid housing. Fluid flow within the space between the outer cylinder and housing is controlled by an end plate construction. The rigid solid end plate construction includes outer peripheral holes, the sizes and number of which are set to determine by-pass flow.