Abstract: Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (II) and compounds of formula (III), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.

Abstract: A modular battery system includes an array of battery modules arranged in at least one stack. Each battery module includes a plurality of battery cells, a first side having positive and negative receptacles and a second side, that is opposite of the first side, having positive and negative plugs. The receptacles and plugs are configured such that adjacent battery modules in a side-by-side relationship are electrically coupled together via plug and receptacle connections and such that the battery modules are electrically coupled together in parallel. An interconnection electrically couples each stack of battery modules together via plug and receptacle connections with one of the battery modules in each stack such that the stacks of battery modules are electrically coupled together in parallel. Each of the battery modules includes a thermal conditioning system configured to thermally isolate the battery module from the other battery modules.

Abstract: Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (I), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.

Abstract: Apparatus is disclosed for separating an amount of a substance from groundwater, comprising an elongate chamber (18) having an inlet (22) which is arranged in use to admit groundwater into the chamber near a lower first end (24). There is also a gas sparger (26) located near the first end (24) which admits gas into the chamber for inducing groundwater to flow from the first end (24) of the chamber toward a second end upper end, and for producing a froth layer (32) which rises above an interface with the groundwater including a concentrated amount of the substance. A suction hood (38) can be moved downward from the top of the chamber (18) into a position to collapse the froth layer (32) and to cause it to be removed from the well body (14). The suction hood (38) (acting as a froth depth regulation device) controls the amount of groundwater in the froth layer (32), which influences the concentration of the contaminant substance achieved in the froth layer (32).

Abstract: An imaging system, optionally an intra-oral camera, includes a blue light source and a barrier filter over a camera sensor. Optionally, the imaging system can also take white light images. Optionally, the system includes positively charged nanoparticles with fluorescein. The fluorescent nanoparticles can be identified on an image of a tooth by machine vision or machine learning algorithms on a pixel level basis. Either white light or fluorescent images can be used, with machine learning or artificial intelligence algorithms, to score the lesions. However, the white light image is not useful for determining whether lesions, particularly ICDAS 0-2 lesions, are active or inactive. A fluorescent image, with the fluorescent nanoparticles, can be used to detect and score active lesions. Optionally using a white light image and a fluorescent image together allows for all lesions, active and inactive, to be located and scored, and for their activity to be determined.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: An apparatus is disclosed comprising a first device for generating aerosol, smoke or vapour from one or more regions of a target, an inlet conduit to an ion analyser or mass spectrometer, the inlet conduit having an inlet through which the aerosol, smoke or vapour passes, and a Venturi pump arrangement arranged and adapted to direct the aerosol, smoke or vapour towards the inlet.

Abstract: A stacked processor-plus-memory device includes a processing die with an array of processing elements of an artificial neural network. Each processing element multiplies a first operand—e.g. a weight—by a second operand to produce a partial result to a subsequent processing element. To prepare for these computations, a sequencer loads the weights into the processing elements as a sequence of operands that step through the processing elements, each operand stored in the corresponding processing element. The operands can be sequenced directly from memory to the processing elements or can be stored first in cache. The processing elements include streaming logic that disregards interruptions in the stream of operands.

Abstract: Row hammer is mitigated by issuing, to a memory device, mitigation operation (MOP) commands in order to cause the refresh of rows at a specified vicinity of a suspected aggressor row. These mitigation operation commands are each associated with respective row addresses that indicate the suspected aggressor row and an indicator of which neighbor row in the vicinity of the suspected aggressor row is to be refreshed. The mitigation operation commands are issued in response to a fixed number of activate commands. The suspected aggressor row is selected by randomly choosing, with equal probability, one of the N previous activate commands to supply its associated row address as the suspected aggressor row address. The neighbor row may be selected randomly with a probability that diminishes inversely with the distance between the suspected aggressor row and the neighbor row.

Abstract: An integrated circuit (IC) memory device includes an array of storage cells configured into multiple banks. Interface circuitry receives refresh commands from a host memory controller to refresh the multiple banks for a first refresh mode. On-die refresh control circuitry selectively generates local refresh commands to refresh the multiple banks in cooperation with the host memory controller during a designated hidden refresh interval in a second refresh mode. Mode register circuitry stores a value indicating whether the on-die refresh control circuitry is enabled for use during the second refresh mode. The interface circuitry includes backchannel control circuitry to transmit a corrective action control signal during operation in the second refresh mode.

Abstract: A high-capacity cache memory is implemented by multiple heterogenous DRAM dies, including a dedicated tag-storage DRAM die architected for low-latency tag-address retrieval and thus rapid hit/miss determination, and one or more capacity-optimized cache-line DRAM dies that render a net cache-line storage capacity orders of magnitude beyond that of state-of-the art SRAM cache implementations. The tag-storage die serves double-duty in some implementations, yielding rapid tag hit/miss determination for cache-line read/write requests while also serving as a high-capacity snoop-filter in a memory-sharing multiprocessor environment.

Abstract: An interconnected stack of one or more Dynamic Random Access Memory (DRAM) die has a base logic die and one or more custom logic or processor die. The processor logic die snoops commands sent to and through the stack. In particular, the processor logic die may snoop mode setting commands (e.g., mode register set—MRS commands). At least one mode setting command that is ignored by the DRAM in the stack is used to communicate a command to the processor logic die. In response the processor logic die may prevent commands, addresses, and data from reaching the DRAM die(s). This enables the processor logic die to send commands/addresses and communicate data with the DRAM die(s). While being able to send commands/addresses and communicate data with the DRAM die(s), the processor logic die may execute software using the DRAM die(s) for program and/or data storage and retrieval.

Abstract: A method of additive manufacturing an article in the ZX (upright) orientation utilizes a composition including specific amounts of a polycarbonate-polysiloxane and polysiloxane-treated titanium dioxide particles. Although addition of titanium dioxide particles to a plastic composition typically reduces impact strength, articles additively manufactured from this composition exhibit improved impact strength relative to articles manufactured from a corresponding composition lacking the polysiloxane-treated titanium dioxide particles.

Abstract: A method for matching color of a part to be printed in an additive manufacturing process, includes: (a) blending a color formulation, the color formulation including a thermoplastic polymer and at least one colorant; (b) printing a color chip from the color formulation in an additive manufacturing process; (c) at least one of measuring or observing a color of the color chip; (d) comparing the color of the color chip to a color of a reference, wherein the reference represents a color of the part to be printed in an additive manufacturing process; and (e) repeating steps (a) through (d) by blending a new color formulation that more closely matches the color of the reference until the color of the color chip matches the color of the reference within an acceptable variance. A color chip formed in the color matching process is also described.

Abstract: The present invention concerns fiber made from a polymer comprising imidazole groups, fiber further having: i) a halide anion, the halide anion being present in an amount of 0.05 to 20.1 weight percent, based on weight of fiber; and ii) sulfur, wherein the sulfur is present in the fiber in an amount of 0.05 to 3 weight percent; the fiber exhibiting hydrochloric acid evolution as identified by TGA-IR between 277.13° C. to 448.19° C.

Abstract: A method for ion beam implantation is provided. The method provides an ion implantation with a multiple-geometric-orientation ion beam that accommodates a range of tilt angles. The range of tilt angles can be defined with a dose distribution specified across the range of tilt angles. The method comprises: acquiring ion implantation parameters, determining the number of exposure steps, selecting implantation parameters corresponding to the exposure steps, acquiring implantation data, defining a first implantation sequence, creating a multiple-geometric-orientation implant exposure sequence according to the first implantation sequence, and performing the ion implantation according to the multiple-geometric-orientation implant exposure sequence.

Abstract: The present invention concerns fiber made from a polymer comprising imidazole groups, fiber further having: i) a halide anion, the halide anion being present in an amount of 0.05 to 20.1 weight percent, based on weight of fiber; and ii) sulfur, wherein the sulfur is present in the fiber in an amount of 0.05 to 3 weight percent; the fiber exhibiting hydrochloric acid evolution as identified by TGA-IR between 277.13° C. to 448.19° C.

Abstract: The present invention concerns fiber made from a polymer comprising imidazole groups, fiber further having: i) a halide anion, the halide anion being present in an amount of 0.05 to 20.1 weight percent, based on weight of fiber; and ii) sulfur, wherein the sulfur is present in the fiber in an amount of 0.05 to 3 weight percent.

Abstract: The present invention concerns methods for producing a yarn comprising the steps of: (a) producing a plurality of dope filaments by spinning a polymer solution in sulfuric acid through a multi-hole spinneret, the polymer comprising imidazole groups; (b) coagulating the plurality of dope filaments into an as-spun yarn; (c) contacting the yarn with an aqueous base having a pKa less than or equal to 11; and (d) rinsing the yarn.

Abstract: The present invention concerns methods for removing sulfur from a fiber comprising the steps of: a) contacting never-dried sulfur-containing fiber in a yarn with an aqueous base having a pKa less than or equal to 11 to release at least a portion of said sulfur, said sulfur comprising, at least in part, sulfate anions and said yarn comprising fiber derived from polymer comprising imidazole groups; and b) rinsing said yarn to remove at least a portion of released sulfur.