Abstract: Provided are compounds, including compositions comprising the same, which function to recruit various target proteins (e.g., client proteins of 14-3-3 proteins) to an E3 ubiquitin ligase enzyme for ubiquitination and subsequent degradation, and methods of using the same.

Abstract: An exterior building panel includes a panel body having a polymeric framing arrangement including an outer boundary portion extending around an outer perimeter of the panel body and a plurality of crossing frame members extending between opposed first and second sides of the outer boundary portion to define a plurality of cavities surrounded by the outer boundary portion, core insulation material disposed in each of the plurality of cavities, an insulation layer surrounding the framing arrangement and the core insulation material, and an insulating lamina coating covering the insulation layer.

Abstract: Embodiments of the invention provide systems and methods of generating a complete and accurate geometrically optimized environment. Stereo pair images depicting an environment are selected from a plurality of images to generate a Digital Surface Model (DSM). Characteristics of objects in the environment are determined and identified. The geometry of the objects may be determined and fit with polygons and textured facades. By determining the objects, the geometry, and the material from original satellite imagery and from a DSM created from the matching stereo pair point clouds, a complete and accurate geometrically optimized environment is created.

Abstract: A cover is disclosed, including: a first gasket that is placed along a portion of the cover that is to join with a heat sink; a second gasket that is placed around a cutout region of the cover, wherein the cover is configured to couple to a circuit board associated with the power module and expose a component on the circuit board through the cutout region; and a fastener that is configured to engage with the heat sink.

Abstract: A method can comprise forming a component comprising a first mating surface; coupling the component to an airfoil having a second mating surface and a Field Assisted Sintering Technology (“FAST”) system; heating, via the FAST system, the airfoil and the component; and applying, via the FAST system, a mechanical pressure between the first mating surface and the second mating surface to join the airfoil to the component and form a blade, the component at least partially defining a leading edge of the blade in response to joining the airfoil to the component

Abstract: Systems, methods, and devices for delivery of an implant to a targeted area of a subject. The systems may include the implant including a plurality of bioresorbable hyaluronan-based fibers and a plurality of non-resorbable fibers, a bone fastener configured to couple the implant to bone, a soft-tissue fastener configured to couple the implant to soft tissue. The systems may include a soft-tissue fastener tool (SFT) configured to couple with and deliver the soft-tissue fastener through the implant and soft-tissue and a bone fastener tool (BFT) configured to couple with and deliver the bone fastener and the implant. The BFT may further be configured to facilitate positioning of at least a portion of the implant over the targeted area after delivery thereto, and a cannula including a cannula passage configured to receive the BFT coupled with the bone fastener and implant therethrough.

Abstract: In one aspect, a system for delivery of an implant to a targeted area of a subject, the system includes the implant includes a plurality of bioresorbable hyaluronan-based fibers and a plurality of non-resorbable fibers, a bone fastener configured to couple the implant to bone, a soft-tissue fastener configured to couple the implant to soft tissue, a soft-tissue fastener tool (SFT) configured to couple with and deliver the soft-tissue fastener through the implant and soft-tissue, a bone fastener tool (BFT) configured to couple with and deliver the bone fastener and the implant. The BFT may further be configured to facilitate positioning of at least a portion of the implant over the targeted area after delivery thereto, and a cannula having a cannula passage. The cannula passage may be configured to receive the BFT coupled with the bone fastener and implant therethrough to secure the implant about the targeted site.

Abstract: The present invention provides an inbred corn line designated ZEDC5810, methods for producing a corn plant by crossing plants of the inbred line ZEDC5810 with plants of another corn plant. The invention further encompasses all parts of inbred corn line ZEDC5810, including culturable cells. Additionally provided herein are methods for introducing transgenes into inbred corn line ZEDC5810, and plants produced according to these methods.

Abstract: The present disclosure relates to adapter assemblies for use with and to electrically and mechanically interconnect electromechanical surgical devices and surgical reloads, and to surgical systems including handheld electromechanical surgical devices and adapter assemblies for connecting surgical reloads to the handheld electromechanical surgical devices.

Abstract: A composition configured for oral use is provided, the composition including a filler in an amount of at least 20% by weight, based on the total weight of the composition, and at least one active ingredient including one or more botanical materials, stimulants, amino acids, vitamins, antioxidants, cannabinoids, pharmaceutical agents, or a combination thereof. The composition further includes a salt and at least one sweetener. The composition has a moisture content of at least about 40% by weight, based on the total weight of the composition.

Abstract: Meltable compositions configured for oral use, the compositions including at least one cannabinoid or cannabimimetic, are provided. The compositions include one or more fillers, typically a sugar alcohol, and a lipid. A method of forming such compositions is also provided.

Abstract: The disclosure provides a nanoemulsion including an oil phase containing at least one cannabinoid and a water phase; wherein at least one of the oil phase and the water phase includes one or more emulsifying agents; and wherein the zeta potential of the nanoemulsion is less than about ?10 mV. Further provided are processes for preparing such nanoemulsions.

Abstract: A device (102) provides respiratory treatment for SDB (including mild OSA) and other respiratory conditions. A flow generator warms and humidifies gas at controlled flow levels. For example, the device (102) delivers breathable gas to the upper airway at flow rates of about 10-35 Liters/minute. Levels of flow rate, temperature and/or humidification of the device may be automatically adjusted in response to the detection of SDB events. The device may also automatically deliver adjustments of any of the levels in accordance with detected phases of respiratory cycles. In some embodiments, the device automatically delivers distinct levels to either of the nares based on independent control of flow to each nare. A warm-up procedure controls temperature and humidity at a desired target during a ramp-up of flow to the set therapy level. A cool-down procedure controls temperature above the dewpoint to avoid condensation internal to the device and patient interface.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g.

Abstract: Devices, systems and methods that track various aspects of a person's sleep and environment to optimize one or more aspects of the user's environment and sleep conditions, quality and duration, together or alone, and help make the one or more users maintain and prolong his or her deep sleep status and improve the their sleep duration and quality.

Abstract: A cover is disclosed, including: a first gasket that is placed along a portion of the cover that is to join with a heat sink; a second gasket that is placed around a cutout region of the cover, wherein the cover is configured to couple to a circuit board associated with the power module and expose a component on the circuit board through the cutout region; and a fastener that is configured to engage with the heat sink.

Abstract: A folding utility knife is provided that includes a blade carrier pivotably secured to a handle. The blade carrier includes a housing in which a blade pocket is formed. The blade pocket defines a top edge and an opposing blade opening; and a pair of side edges located on opposite sides of the blade pocket, extending between the top edge and the blade opening. The blade pocket also defines a pair of detents located proximate the pair of side edges, between the top edge and the blade opening, spatially separated from the top edge and the blade opening. The blade pocket is contoured to fit a top portion of a utility blade that includes a pair of openings, and the pair of detents are contoured to fit within the pair of openings to position and hold the top portion of the utility blade within the blade pocket.

Abstract: A utility blade is provided that includes a blade body having a convex quadrilateral shape. The blade body defines a top edge, a linear cutting edge on an opposite side of the blade body from the top edge, and a pair of side edges located on opposite sides of the blade body, extending between the top edge and the linear cutting edge. The blade body also defines a pair of openings located proximate the pair of side edges, between the top edge and the linear cutting edge; and the pair of openings are spatially separated from the top edge and the linear cutting edge. A top portion of the utility blade is contoured to fit within a holder that includes a pair of detents, and the pair of openings contoured to fit the pair of detents to position and hold the utility blade within the holder.