Abstract: Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (II) and compounds of formula (III), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.

Abstract: Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (I), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.

Abstract: Low profile offset reamers include reamer heads with outer diameters that are substantially greater than the overall height of the working portion, which includes the reamer head, a reamer coupler, and a working tip that supports the reamer head and reamer coupler. The overall height is measured parallel to the rotational axis of the reamer head, and the outer diameter is measured perpendicular to the rotational axis.

Abstract: Low profile offset reamers include reamer heads with outer diameters that are substantially greater than the overall height of the working portion, which includes the reamer head, a reamer coupler, and a working tip that supports the reamer head and reamer coupler. The overall height is measured parallel to the rotational axis of the reamer head, and the outer diameter is measured perpendicular to the rotational axis.

Abstract: Arthroplasty components include an articular surface and a bone-facing surface. In some examples, the bone-facing surface bears at least one anchoring element adapted for an oblique implantation trajectory. The anchoring element includes a reinforcement plate, a dowel, and surface features. Each surface feature resists forces acting along a different direction. In other examples, the bone-facing surface bears anchoring elements that deform along the primary or longest axis of the anchoring element during insertion. In yet other examples, the bone-facing surface is enlarged relative to the articular surface so that at least a portion of the perimeter of the articular surface is circumscribed by the perimeter of the bone-facing surface.

Abstract: A drill guide includes a working portion and a shaft, with a joint formed between the working portion and the shaft so that the shaft is movable relative to the working portion about the joint. The working portion includes at least one drill guide hole which receives a drill for making a hole in a bone. The joint isolates the working portion from unintentional movements of the shaft so that the working portion remains stable against a bone surface. The joint also enables the shaft to be used as a retractor or pry bar against surrounding anatomical structures if desired. The drill guide may be included in a system with an implant component and/or other surgical instruments.

Abstract: Arthroplasty components include an articular surface and a bone-facing surface. In some examples, the bone-facing surface bears at least one anchoring element adapted for an oblique implantation trajectory. The anchoring element includes a reinforcement plate, a dowel, and surface features. Each surface feature resists forces acting along a different direction. In other examples, the bone-facing surface bears anchoring elements that deform along the primary or longest axis of the anchoring element during insertion. In yet other examples, the bone-facing surface is enlarged relative to the articular surface so that at least a portion of the perimeter of the articular surface is circumscribed by the perimeter of the bone-facing surface.

Abstract: Low profile offset reamers include reamer heads with outer diameters that are substantially greater than the overall height of the working portion, which includes the reamer head, a reamer coupler, and a working tip that supports the reamer head and reamer coupler. The overall height is measured parallel to the rotational axis of the reamer head, and the outer diameter is measured perpendicular to the rotational axis.

Abstract: A drill guide includes a working portion and a shaft, with a joint formed between the working portion and the shaft so that the shaft is movable relative to the working portion about the joint. The working portion includes at least one drill guide hole which receives a drill for making a hole in a bone. The joint isolates the working portion from unintentional movements of the shaft so that the working portion remains stable against a bone surface. The joint also enables the shaft to be used as a retractor or pry bar against surrounding anatomical structures if desired. The drill guide may be included in a system with an implant component and/or other surgical instruments.

Abstract: Arthroplasty components include an articular surface and a bone-facing surface. The bone-facing surface bears at least one anchoring element adapted for an oblique implantation trajectory. The anchoring element includes a reinforcement plate, a dowel, and surface features. Each surface feature resists forces acting along a different direction.

Abstract: Arthroplasty components include an articular surface and a bone-facing surface. The bone-facing surface bears at least one anchoring element adapted for an oblique implantation trajectory. The articular surface includes a larger radius of curvature in the superior-inferior direction than in the anterior-posterior direction. An inferior chamfer may be present on the articular surface. Instruments and implantation methods are also disclosed. Reamers include reamer heads coupled to various offset shaft configurations.

Abstract: Arthroplasty components include an articular surface and a bone-facing surface. In some examples, the bone-facing surface bears at least one anchoring element adapted for an oblique implantation trajectory. The anchoring element includes a reinforcement plate, a dowel, and surface features. Each surface feature resists forces acting along a different direction. In other examples, the bone-facing surface bears anchoring elements that deform along the primary or longest axis of the anchoring element during insertion. In yet other examples, the bone-facing surface is enlarged relative to the articular surface so that at least a portion of the perimeter of the articular surface is circumscribed by the perimeter of the bone-facing surface.

Abstract: Arthroplasty components include an articular surface and a bone-facing surface. The bone-facing surface bears at least one anchoring element adapted for an oblique implantation trajectory. The articular surface includes a larger radius of curvature in the superior-inferior direction than in the anterior-posterior direction. An inferior chamfer may be present on the articular surface. Instruments and implantation methods are also disclosed.

Abstract: Arthroplasty components include an articular surface and a bone-facing surface. The bone-facing surface bears at least one anchoring element adapted for an oblique implantation trajectory. The articular surface may include a larger radius of curvature in the superior-inferior direction than in the anterior-posterior direction. An inferior chamfer may be present on the articular surface. Instruments and implantation methods are also disclosed.

Abstract: Arthroplasty components include an articular surface and a bone-facing surface. The bone-facing surface bears at least one anchoring element adapted for an oblique implantation trajectory. The anchoring element includes a reinforcement plate, a dowel, and surface features. Each surface feature resists forces acting along a different direction.

Abstract: Arthroplasty components include an articular surface and a bone-facing surface. The bone-facing surface bears at least one anchoring element adapted for an oblique implantation trajectory. The articular surface includes a larger radius of curvature in the superior-inferior direction than in the anterior-posterior direction. An inferior chamfer may be present on the articular surface. Instruments and implantation methods are also disclosed. Reamers include reamer heads coupled to various offset shaft configurations.