Abstract: Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (I), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.

Abstract: Systems and methods for a content database storing extracted content. A content manager engine executing on a computer system performs various functions in relation to the content database. The content manager engine may extract content fragments from documents of different document types and store the content fragments to content entries of the content database. The content manager engine may reproduce a selected document using the content database, allow direct modification of content entries, merge two or more documents of different types into a single document, and create a new document based on the content entries.

Abstract: Systems and methods for a content database storing extracted content. A content manager engine executing on a computer system performs various functions in relation to the content database. The content manager engine may extract content fragments from documents of different document types and store the content fragments to content entries of the content database. The content manager engine may reproduce a selected document using the content database, allow direct modification of content entries, and merge two documents of different types into a single document. The content manager engine may also be configured to produce a solution document using the content database based on one or more received user selections. A solution document may be provided to address issues or queries regarding computer system hardware or software. The solution document may comprise a description of any services, products, and/or technologies related to the issue or query.

Abstract: Systems and methods for a content database storing extracted content. A content manager engine executing on a computer system performs various functions in relation to the content database. The content manager engine may extract content fragments from documents of different document types and store the content fragments to content entries of the content database. The content manager engine may reproduce a selected document using the content database, allow direct modification of content entries, and merge two documents of different types into a single document. The content manager engine may also be configured to produce a solution document using the content database based on one or more received user selections. A solution document may be provided to address issues or queries regarding computer system hardware or software. The solution document may comprise a description of any services, products, and/or technologies related to the issue or query.

Abstract: Systems and methods for a content database storing extracted content. A content manager engine executing on a computer system performs various functions in relation to the content database. The content manager engine may extract content fragments from documents of different document types and store the content fragments to content entries of the content database. The content manager engine may reproduce a selected document using the content database, allow direct modification of content entries, and merge two documents of different types into a single document. The content manager engine may also be configured to produce a solution document using the content database based on one or more received user selections. A solution document may be provided to address issues or queries regarding computer system hardware or software. The solution document may comprise a description of any services, products, and/or technologies related to the issue or query.

Abstract: An article of footwear includes an upper and a sole assembly secured to the upper. The sole assembly has at least one fluid-filled chamber capable of transmitting light and a recess. A light source is positioned in the recess, and an outsole is secured to a lower surface of the sole assembly.

Abstract: The invention provides method and apparatus that utilize a plurality of port sub-arrays, in which each port sub-array comprises a plurality of acoustical ports. The ports of each port sub-array are spaced so that each port sub-array responds to acoustical signals that are generated by acoustical sources within an associated frequency range. In an embodiment of the invention, associated frequency ranges are related in a harmonic manner, in which each port sub-array corresponds to different frequency octaves. The associated frequency range is a portion of the total frequency range of an acoustical system. Received acoustical signals from each of the port sub-arrays are coupled over acoustical pathways and are converted into electrical signals by capsules that may be mounted in a capsule mounting. The electrical signals may be filtered, such as to reduce spatial aliasing, and post processed to further enhance the characteristics of the signals.

Abstract: The invention provides method and apparatus that utilize a plurality of port sub-arrays, in which each port sub-array comprises a plurality of acoustical ports. The ports of each port sub-array are spaced so that each port sub-array responds to acoustical signals that are generated by acoustical sources within an associated frequency range. In an embodiment of the invention, associated frequency ranges are related in a harmonic manner, in which each port sub-array corresponds to different frequency octaves. The associated frequency range is a portion of the total frequency range of an acoustical system. Received acoustical signals from each of the port sub-arrays are coupled over acoustical pathways and are converted into electrical signals by capsules that may be mounted in a capsule mounting. The electrical signals may be filtered, such as to reduce spatial aliasing, and post processed to further enhance the characteristics of the signals.

Abstract: In the registration of images on a substrate, a substrate parameter is determined for the substrate. A bin data set defining a plurality of bins that each delimit a range of substrate parameters and have an associated bin instruction is retrieved. The particular bin that contains the determined substrate parameter and its associated bin instruction is identified. In response to this bin instruction, the determination of the substrate parameter is repeated, the substrate is rejected, or an image is scaled and registered on the substrate.

Abstract: A nucleoprotein based nanoprocessor is described. The nanoprocessor includes one or more chimelic fusion proteins linked to a DNA scaffold. Both components of the fusion protein are enzymes.

Abstract: A nucleoprotein based nanoprocessor is described. The nanoprocessor includes one or more chimeric fusion proteins linked to a DNA scaffold. Both components of the fusion protein are enzymes.

Abstract: A reverse transcriptase assay is described. A modular nanostructure comprising relatively small and relatively long RNA sequences is utilized in the assay.

Abstract: Molecules having an RNA block linked to a shorter DNA block is described. The RNA and DNA blocks are complementary to accommodate formation of fold-back molecules having a 3' hydroxyl on the DNA block and an overhanging RNA strand at the end of a short DNA-RNA hybrid.

Abstract: Novel synthetic oligomers of unique three-dimensional structure comprising homologous and heterologous blocks, some of which may self-associate are described. Also disclosed is a synthetic oligonucleotide that includes 5-fluorocytosine residues at positions corresponding to methylation sites of DNA-cytosine methyltransferase and a method for preparing such a molecule.

Abstract: The emulator includes first and second pipelined stages connected through a bidirectional bus for executing source instructions normally executed by a different/source computer in a highly overlapped manner. The first stage includes an emulator chip which performs the function of fetching and decoding each source instruction stored in cache memory resulting in the generation of a number of vector addresses required for executing the instruction by the second stage. The second stage includes a high performance microprocessor chip having on-chip instruction and data caches for storing a plurality of emulation subroutines and data fetched during subroutine execution. In pipelined fashion, the emulator chip fetches and decodes each source instruction which generates a vector branch address which is loaded into the branch vector register while the microprocessor chip fetches and executes emulation subroutines specified by the vector address transferred via the bus for each previously decoded source instruction.

Abstract: A system includes first and second processing units which are interconnected by a bidirectional bus. The first processing unit is a microprocessor chip programmed for executing procedures stored in an on-chip instruction cache unit. The second processing unit receives requests from an external source such as a system bus. The microprocessor chip includes a branch vector facility which connects to the bus. The second processing unit in response to an external request, generates a vector branch address. The processing unit transfers the vector branch address to the branch vector facility for storage along with setting a write indicator. The microprocessor chip, upon detecting that the write indicator was set, branches to the procedure specified by the branch vector address for executing the instructions of the procedure to carry out those operations required for processing the external request or event.