Abstract: The invention provides methods and pharmaceutical compositions for treating certain cancers with compounds of formula (I) wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts and prodrugs.

Abstract: A bearing surface having increased wear resistance. Generally, certain aspects of the present invention are directed to an implant design based on concepts of unidirectional load application and the use of engineered surfaces to increase the amount of lubricant at the bearing surface, to thereby reduce wear of the bearing surface. Surfaces of certain bearing surface embodiments are fabricated to maximize lubricant retention, encourage lubricant entrainment, and/or restrict lubricant escape from the bearing surface. Preferably, when used in orthopedic applications, such bearing surfaces are optimized based on the unique characteristics of human biomechanical loading.

Abstract: The present invention provides a bone in-growth and on-growth material and method for making a material by bonding porous sheets together. The porosity is controllable from zero porosity to essentially a fully porous material.