Abstract: An endoscope comprises a handle and a shaft with an optical housing at the distal end of the shaft enclosing a camera sensor positioned so that its optical axis is at an angle with respect to a rotational axis of the shaft. The camera sensor is rotatable with the shaft relative to a proximal housing of the handle. A rotation sensor in the handle detects the rotational angle of the camera sensor with respect to the proximal housing. A processor can correct the angular orientation of an image from the image sensor, converting of a rotating variable field of view to a translating variable field of view. A processor can apply variable smoothing of the rotation of the displayed image so that smoothing during rotational deceleration is greater than smoothing during rotational acceleration. The shaft may be enclosed in a trocar that allows for a space between the shaft and trocar that can be used to carry irrigation fluid to or from a space at the end of the shaft.

Abstract: IGF and IGFBP are administered to stimulate new bone formation in subjects with bone loss due to bone marrow disorders, connective tissue disorders, drugs, pregnancy, lactation, chronic hypophosphatemia, hyperphosphatasia, insulin-dependent diabetes mellitus, anorexia nervosa, cadmium poisoning, juvenile osteoporosis, Paget's disease of bone, osteoarthritis and periodontal disease. IGF-I and IGFBP-3 are optionally combined with agents that inhibit bone resorption.

Abstract: Bone growth factors are used to stimulate new bone formation when administered with agents that inhibit bone resorption. These therapeutic combinations result in an enhanced rate of bone formation with an increase in bone mass.