Abstract: The disclosure relates to USP30 Inhibitor Compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, and medical uses involving same.

Abstract: The present disclosure relates to non-natural NKG2D receptors attached to mammalian cell surfaces wherein the non-natural receptors do not directly signal or directly activate the cell when the receptor is bound by cognate non-natural ?1-?2 domains of NKG2D ligands modified to specifically bind the non-natural NKG2D receptors. The non-natural ?1-?2 domains of NKG2D ligands may be attached to heterologous atoms or molecules including polypeptides, in some embodiments cytokines or modified cytokines, antibodies or fragments of antibodies.

Abstract: Disclosed herein are systems and methods for treating a magnesium or a magnesium alloy substrate. The system includes a cleaning composition having a pH greater than 8.5 or a solvent, and a pretreatment composition comprising an organophosphate compound and/or an organophosphonate compound. The method includes contacting a substrate surface with the cleaning composition or the solvent, and contacting the surface with the pretreatment composition. Also disclosed are substrates treated with one of the systems or methods. Also disclosed are magnesium or magnesium alloy substrates wherein, between the air/substrate interface and 500 nm below the air/substrate interface (a) oxygen and magnesium are present in a combined amount of at least 70 atomic %; (b) carbon is present in an amount of no more than 30 atomic %; and/or (c) fluoride is present in an amount of no more than 8 atomic %, wherein atomic % is measured by XPS depth profiling.

Abstract: Methods and apparatus for individually molding objects as part of a marketing promotion. Various embodiments pertain to the use of individualized molds to simultaneously produce a plurality of molded consumer objects, each having molded individualized indicia. In other embodiments the molded individualized indicia further interrelates to additional individualized indicia that is printed in association with the molded object, such as on a label or a cap.

Abstract: A glass bottle with improved pouring characteristics. In some embodiments the bottle can hold pressurized liquid. The bottle includes a neck with a non-circular cross section. The cross sectional shape of the neck is adapted and configured to provide less turbulence in the liquid being poured out of the bottle, and further to assist in separating the in flow of single phase liquid from the turbulent mixed flow of two phase, gas-liquid substances.