Patents by Inventor Steven W. Metzger
Steven W. Metzger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11603550Abstract: Systems and methods for rapid determination of microorganism growth and antimicrobial agent susceptibility and/or resistance are disclosed.Type: GrantFiled: April 11, 2017Date of Patent: March 14, 2023Assignee: Accelerate Diagnostics, Inc.Inventors: Alena Shamsheyeva, David C. Howson, Steven W. Metzger
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Publication number: 20220099671Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: ApplicationFiled: May 12, 2021Publication date: March 31, 2022Applicant: Accelerate Diagnostics, Inc.Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Patent number: 11054420Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: GrantFiled: November 30, 2017Date of Patent: July 6, 2021Assignee: Accelerate Diagnostics, Inc.Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Publication number: 20210008541Abstract: Systems and methods for automated biological sample preparation for use in rapid identification and antimicrobial susceptibility testing of microorganisms, such as bacteria and fungi, are provided.Type: ApplicationFiled: June 22, 2020Publication date: January 14, 2021Inventors: Kevin Marshall, Austin Ashby, Josh Harrison, Steven W. Metzger, Wayne Showalter, Erik Molina, Jamie Roberson
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Patent number: 10669566Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.Type: GrantFiled: June 13, 2018Date of Patent: June 2, 2020Assignee: Accelerate Giagnostics, Inc.Inventors: William L. Richards, Austin Ashby, Matthew Ketterer, Kevin Marshall, Josh Harrison, Matthew Mette, Paul Richards, Wayne Showalter, Jasmin Cote, Steven W. Metzger, Ken Hance, Meghan Mensack, Carlos Michel, Elke Allers, Dulini Gamage, Landon Prisbrey, Oleg Gusyatin, Alena Shamsheyeva, Ben Turng, Andrew Ghusson, Kurt Reinhardt, Phillip C. Halbert, Solene Bourgeois
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Patent number: 10254204Abstract: Methods and systems for purifying one or more microbial cells and/or viruses from a biological sample are provided. The biological sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the microbial cells and/or viruses in the well. The microbial cells and/or viruses can be removed from the well, and optionally adhered or fixed to a surface, or detected. In one embodiment, the microbial cells and/or viruses are retained in the well by embedding in the medium. The medium including the embedded microbial cells and/or viruses may be excised or otherwise removed and transferred to a glass slide or other solid surface.Type: GrantFiled: May 3, 2017Date of Patent: April 9, 2019Assignee: Accelerate Diagnostics, Inc.Inventors: Landon Prisbrey, Elise Blackmore, Kenneth R. Hance, Steven W. Metzger, Kevin Marshall
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Patent number: 10253355Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing. Automated quality control test components and methods of their use are also disclosed.Type: GrantFiled: October 3, 2016Date of Patent: April 9, 2019Assignee: Accelerate Diagnostics, Inc.Inventors: William L. Richards, Austin Ashby, Matthew Ketterer, Kevin Marshall, Josh Harrison, Matthew Mette, Paul Richards, Wayne Showalter, Jasmin Cote, Phillip C. Halbert, Solene Bourgeois, Steven W. Metzger, Ken Hance, Meghan Mensack, Carlos Michel, Elke Allers, Dulini Gamage, Landon Prisbrey, Oleg Gusyatin, Alena Shamsheyeva, Ben Turng, Andrew Ghusson, Kurt Reinhardt
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Patent number: 10202597Abstract: Methods and systems for purifying cells and/or viruses are provided. The sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the cells and/or viruses in the well. The cells and/or viruses can be removed from the well, and optionally adhered or fixed to a surface, or detected. In one embodiment, the cells and/or viruses may be retained in the well by embedding in the medium. The medium including the embedded cells and/or viruses may be excised or otherwise removed and transferred to a glass slide or other solid surface.Type: GrantFiled: August 12, 2016Date of Patent: February 12, 2019Assignee: Accelerate Diagnostics, Inc.Inventors: Steven W. Metzger, Kenneth Robert Hance
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Publication number: 20180291419Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.Type: ApplicationFiled: June 13, 2018Publication date: October 11, 2018Applicant: Accelerate Diagnostics, Inc.Inventors: William L. Richards, Austin Ashby, Matthew Ketterer, Kevin Marshall, Josh Harrison, Matthew Mette, Paul Richards, Wayne Showalter, Jasmin Cote, Steven W. Metzger, Ken Hance, Meghan Mensack, Carlos Michel, Elke Allers, Dulini Gamage, Landon Prisbrey, Oleg Gusyatin, Alena Shamsheyeva, Ben Turng, Andrew Ghusson, Kurt Reinhardt, Phillip C. Halbert, Solene Bourgeois
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Patent number: 10023895Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.Type: GrantFiled: March 30, 2016Date of Patent: July 17, 2018Assignee: Accelerate Diagnostics, Inc.Inventors: William L. Richards, Austin Ashby, Matthew Ketterer, Kevin Marshall, Josh Harrison, Matthew Mette, Paul Richards, Wayne Showalter, Jasmin Cote, Phillip C. Halbert, Solene Bourgeois, Steven W. Metzger, Ken Hance, Meghan Mensack, Carlos Michel, Elke Allers, Dulini Gamage, Landon Prisbrey, Oleg Gusyatin, Alena Shamsheyeva, Ben Turng, Andrew Ghusson, Kurt Reinhardt
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Publication number: 20180080932Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: ApplicationFiled: November 30, 2017Publication date: March 22, 2018Applicant: Accelerate Diagnostics, Inc.Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Patent number: 9841422Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: GrantFiled: July 11, 2014Date of Patent: December 12, 2017Assignee: Accelerate Diagnostics, Inc.Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
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Publication number: 20170234781Abstract: Methods and systems for purifying one or more microbial cells and/or viruses from a biological sample are provided. The biological sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the microbial cells and/or viruses in the well. The microbial cells and/or viruses can be removed from the well, and optionally adhered or fixed to a surface, or detected. In one embodiment, the microbial cells and/or viruses are retained in the well by embedding in the medium. The medium including the embedded microbial cells and/or viruses may be excised or otherwise removed and transferred to a glass slide or other solid surface.Type: ApplicationFiled: May 3, 2017Publication date: August 17, 2017Applicant: Accelerate Diagnostics, Inc.Inventors: Landon Prisbrey, Elise Blackmore, Kenneth R. Hance, Steven W. Metzger, Kevin Marshall
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Publication number: 20170218426Abstract: This disclosure is related to systems and methods for rapid determination of microorganism growth and antimicrobial agent susceptibility and/or resistance.Type: ApplicationFiled: April 11, 2017Publication date: August 3, 2017Applicant: Accelerate Diagnostics, Inc.Inventors: Alena Shamsheyeva, David C. Howson, Steven W. Metzger
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Patent number: 9714420Abstract: Methods and systems for purifying cells and/or viruses are provided. The sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the cells and/or viruses in the well. The cells and/or viruses can be removed from the well, and optionally adhered or fixed to a surface, or detected. In one embodiment, the cells and/or viruses may be retained in the well by embedding in the medium. The medium including the embedded cells and/or viruses may be excised or otherwise removed and transferred to a glass slide or other solid surface.Type: GrantFiled: January 21, 2016Date of Patent: July 25, 2017Assignee: Accelerate Diagnostics, Inc.Inventors: Steven W. Metzger, Kenneth Robert Hance
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Patent number: 9677109Abstract: This disclosure is related to systems and methods for rapid determination of microorganism growth and antimicrobial agent susceptibility and/or resistance.Type: GrantFiled: March 13, 2014Date of Patent: June 13, 2017Assignee: Accelerate Diagnostics, Inc.Inventors: Alena Shamsheyeva, David C. Howson, Steven W. Metzger
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Patent number: 9657327Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.Type: GrantFiled: March 15, 2013Date of Patent: May 23, 2017Assignee: Accelerate Diagnostics, Inc.Inventors: Steven W. Metzger, David C. Howson, David A. Goldberg, Daniel A. Buttry
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Publication number: 20170023599Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing. Automated quality control test components and methods of their use are also disclosed.Type: ApplicationFiled: October 3, 2016Publication date: January 26, 2017Applicant: Accelerate Diagnostics, Inc.Inventors: William L. Richards, Austin Ashby, Matthew Ketterer, Kevin Marshall, Josh Harrison, Matthew Mette, Paul Richards, Wayne Showalter, Jasmin Cote, Phillip C. Halbert, Solene Bourgeois, Steven W. Metzger, Ken Hance, Meghan Mensack, Carlos Michel, Elke Allers, Dulini Gamage, Landon Prisbrey, Oleg Gusyatin, Alena Shamsheyeva, Ben Turng, Andrew Ghusson, Kurt Reinhardt
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Publication number: 20160348091Abstract: Methods and systems for purifying cells and/or viruses are provided. The sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the cells and/or viruses in the well. The cells and/or viruses can be removed from the well, and optionally adhered or fixed to a surface, or detected. In one embodiment, the cells and/or viruses may be retained in the well by embedding in the medium. The medium including the embedded cells and/or viruses may be excised or otherwise removed and transferred to a glass slide or other solid surface.Type: ApplicationFiled: August 12, 2016Publication date: December 1, 2016Applicant: Accelerate Diagnostics, Inc.Inventors: Steven W. Metzger, Kenneth Robert Hance
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Publication number: 20160289729Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.Type: ApplicationFiled: March 30, 2016Publication date: October 6, 2016Applicant: Accelerate Diagnostics, Inc.Inventors: William L. Richards, Austin Ashby, Matthew Ketterer, Kevin Marshall, Josh Harrison, Matthew Mette, Paul Richards, Wayne Showalter, Jasmin Cote, Phillip C. Halbert, Solene Bourgeois, Steven W. Metzger, Ken Hance, Meghan Mensack, Carlos Michel, Elke Allers, Dulini Gamage, Landon Prisbrey, Oleg Gusyatin, Alena Shamsheyeva, Ben Turng, Andrew Ghusson, Kurt Reinhardt