Abstract: Bifunctional compounds, which find utility as modulators of non-receptor Leucine-rich repeat kinase 2 (LRRK2), are described herein. In particular, the bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds LRRK2, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Abstract: Bifunctional compounds, which find utility as modulators of leucine-rich repeat kinase 2 (LRRK2), are described herein. In particular, the hetero-bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds LRRK2, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The hetero-bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Abstract: Described herein are compounds of Formula I, wherein the variables are defined herein, their use as HSD17B13 inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, NAFLD and NASH.

Abstract: Some embodiments provide an irrigation flow sensor system, comprising: a housing forming a fluid channel to cooperate with conduits of an irrigation system; a paddle wheel device with at least a first blade of a set of the blades comprises a magnetic element; the paddle wheel device is positioned with at least a portion of the blades extends into the fluid channel as the blades rotate about an axis; a magnetic sensor proximate a pathway of the magnetic element as it rotates configured to provide a sensor output every time the magnetic element passes the magnetic sensor; a switch coupled to the magnetic sensor and a current loop, wherein the switch in an activate state is configured to temporarily change the current in the current loop in response to the sensor output, with a rate of change in current corresponding to a flow rate of the fluid flowing.

Abstract: This disclosure provides various techniques for providing fine-grain digital and analog pixel compensation to account for voltage error across an electronic display. By employing a two-dimensional digital compensation and a local analog compensation, a fine-grain and robust pixel compensation scheme may be provided to the electronic display.

Abstract: Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

Abstract: Disclosed is a laser system including a first laser and a second laser. The first laser includes a laser cavity, and a gas phase molecular gain medium disposed in the laser cavity, the gain medium having an absorption band. The second laser is a solid state laser configured to be continuously tunable, with respect to an emission wavelength of the second laser, over the absorption band of the gain medium, and the second laser is tuned to pump rotational vibrational transitions in the gain medium to achieve a rotational population inversion.

Abstract: Computing system enhancements make container instantiation faster, reduce layer content storage demands, and make more container image formats available. A container instantiation location sends a container image pull request to a container registry, receives an image manifest, sends a layer mount request to the registry instead of a layer content download request, receives a layer mount, optionally repeats for additional layers, creates a union file system spanning the layers, and launches a container process based on the union file system without first downloading all the layer content.

Abstract: Non-human animals comprising a human or humanized IL-4 and/or IL-4R? nucleic acid sequence are provided. Non-human animals that comprise a replacement of the endogenous IL-4 gene and/or IL-4R? gene with a human IL-4 gene and/or IL-4R? gene in whole or in part, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized IL-4 gene under control of non-human IL-4 regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4-encoding sequence with human IL-4-encoding sequence at an endogenous non-human IL-4 locus. Non-human animals comprising a human or humanized IL-4R? gene under control of non-human IL-4R? regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4R?-encoding sequence with human or humanized IL-4R?-encoding sequence at an endogenous non-human C IL-4R? locus.

Abstract: One or more radar sensors can be used to monitor patients in a variety of different environments and embodiments. In one embodiment, radar sensors can be used to monitor a patient's breathing, including monitoring of tidal volume, chest expansion distance, breathing rate, etc. In another embodiment, a patient position can be monitored in a patient bed, which can be used as feedback for control of bladders of a patient bed. Additional embodiments are described herein.

Abstract: An antenna structure includes a first signal connector and a second signal connector. The antenna structure further includes a cavity antenna defined by a set of planar walls. The cavity antenna is coupled to the first signal connector and configured to emit a field polarized linearly in a first direction when driven by a signal at the first signal connector. The antenna structure further includes a dipole antenna defined by a pair of arms that are integrated with a wall of the cavity antenna. The dipole antenna is coupled to the second signal connector and configured to a field polarized linearly in a second direction offset from the first direction when driven by a signal at the second signal connector.

Abstract: The present disclosure is directed to compounds of Formula (1): wherein m, n, Y, R1, R2, R3, R4 and R5 are each as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, and pharmaceutical compositions comprising the compounds of Formula (I), as described herein, which are useful as voltage-gated potassium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.

Abstract: A system and method of manufacturing an aluminum fuel cell cradle are provided. The method comprises providing a negative cast mold having cavities to form the cradle, and comprises providing a feeding mechanism disposed about the mold and in fluid communication with the cavities thereof. The feeding mechanism comprises a plurality of primary risers connected to and in fluid communication with cavities. The method further comprises melting a first metallic material to define a molten metallic material, and comprises moving the mold to a vertical casting orientation about a rotational axis, while feeding molten metallic material through the runner to the cavities. The method further comprises cooling the molten metallic material to define a solidified metallic material. A second solidification time in the risers is greater than a first solidification time in the mold such that shrinkage of the solidified metallic material occurs in the risers away from the mold.

Abstract: A fog-based self-powered system for collecting atmospheric water and generating electricity is presented. The system includes a mesh-based fog harvester for accumulating water droplets from atmospheric moisture. A droplet distributor receives accumulated water droplets from the mesh-based fog harvester. A droplet electrical generator harvests energy from the water droplets accumulated in the droplet distributor. The droplet electrical generator includes an electret surface for receiving the water droplets from the droplet distributor and at least two electrodes. A water reservoir receives water droplets from the droplet electrical generator.

Abstract: An electronic device display may have pixels formed from crystalline semiconductor light-emitting diode dies, organic light-emitting diodes, or other pixel structures. The pixels may be formed on a display panel substrate. A display panel may extend continuously across the display or multiple display panels may be tiled in two dimensions to cover a larger display area. Interconnect substrates may have outwardly facing contacts that are electrically shorted to corresponding inwardly facing contacts such as inwardly facing metal pillars associated with the display panels. The interconnect substrates may be supported by glass layers. Integrated circuits may be embedded in the display panels and/or in the interconnect substrates. A display may have an active area with pixels that includes non-spline pixels in a non-spline display portion located above a straight edge of the display and spline pixel in a spline display portion located above a curved edge of the display.

Abstract: Various embodiments are disclosed for providing machine learning routines with peripheral device data to infer driver activity and location. Peripheral device data may be collected on a peripheral device having a machine learning routine executing thereon to infer driver activity and perform improved estimation of driver location. Using driver activity and location estimation, contextually relevant delivery workflow assistance may be automatically provided to a delivery driver or other individual without requiring manual input, thereby improving driver safety and operational efficiency.

Abstract: A wearable computing device includes a housing having a wrist-side face configured to sit against a wrist of a user of the wearable computing device when being worn by the user, an electronic display arranged within the housing, a plurality of biometric sensor electrodes positioned on the wrist-side face so as to maintain skin contact with the user when being worn on the wrist by the user, and at least one driver communicatively coupled to the plurality of biometric sensor electrodes. Each of the plurality of biometric sensor electrodes continuously measures, at least, one or more parameters indicative of electrical impedance of the user at a location of the skin contact.

Abstract: Methods for centralized access control for cloud relational database management system resources are performed by systems and devices. The methods utilize a central policy storage, managed externally to database servers, which stores external policies for access to internal database resources at up to fine granularity. Database servers in the processing system each receive external access policies that correspond to users of the system by push or pull operations from the central policy storage, and store the external access policies in a cache of the database servers for databases. For resource access, access conditions are determined via policy engines of database servers based on an external access policy in the cache that corresponds to a user, responsive to a resource access request from a device of the user specifying the internal resource. Data associated with the resource is provided to the user based on the access condition being met.

Abstract: The present invention relates to a non-invasive cardiac monitoring device that records cardiac data to infer physiological characteristics of a human, such as cardiac arrhythmia. Some embodiments of the invention allow for long-term monitoring of physiological signals. Further embodiments allow for processing of the detected cardiac rhythm signals partially on the wearable cardiac monitor device, and partially on a remote computing system. Some embodiments include a wearable cardiac monitor device for long-term adhesion to a mammal for prolonged detection of cardiac rhythm signals.